• Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients 

  Taylor, JC; Bongartz, T; Massey, J; Mifsud, B; Spiliopoulou, A; Scott, IC; Wang, J; Morgan, M; Plant, D; Colombo, M (Springer Nature, 2018-05-25)

  Methotrexate (MTX) monotherapy is a common first treatment for rheumatoid arthritis (RA), but many patients do not respond adequately. In order to identify genetic predictors of response, we have combined data from two ...

• Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury. 

  Voisin, M-B; Leoni, G; Woodfin, A; Loumagne, L; Patel, NSA; Di Paola, R; Cuzzocrea, S; Thiemermann, C; Perretti, M; Nourshargh, S (Wiley, 2019-01-11)

  Ischemia/reperfusion (I/R) injury is a severe inflammatory insult associated with numerous pathologies such as myocardial infarction, stroke and acute kidney injury. I/R injury is characterized by a rapid influx of activated ...

• Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 

  Pulit, SL; Stoneman, C; Morris, AP; Wood, AR; Glastonbury, CA; Tyrrell, J; Yengo, L; Ferreira, T; Marouli, E; Ji, Y (Oxford University Press, 2018-09-04)

  More than one in three adults worldwide is either overweight or obese. Epidemiological studies indicate that the location and distribution of excess fat, rather than general adiposity, are more informative for predicting ...

• Nicotinamide Nucleotide Transhydrogenase as a Novel Treatment Target in Adrenocortical Carcinoma. 

  Chortis, V; Taylor, AE; Doig, CL; Walsh, MD; Meimaridou, E; Jenkinson, C; Rodriguez-Blanco, G; Ronchi, CL; Jafri, A; Metherell, LA (Oxford University Press, 2018-08-01)

  Adrenocortical carcinoma (ACC) is an aggressive malignancy with poor response to chemotherapy. In this study, we evaluated a potential new treatment target for ACC, focusing on the mitochondrial reduced form of NAD ...

• SGPL1 Deficiency: A Rare Cause of Primary Adrenal Insufficiency. 

  Settas, N; Persky, R; Faucz, FR; Sheanon, N; Voutetakis, A; Lodish, M; Metherell, LA; Stratakis, CA (Oxford University Press, 2018-12-03)

  Context Multiple autosomal recessive genes have been etiologically linked to Primary Adrenal Insufficiency (PAI). Recently, SGPL1 gene mutations were recognized as causes of steroid-resistant nephrotic syndrome type 14 ...

• Genetic Variability in Both the Adaptive and Innate Immune Systems Contribute to Alzheimer's and Parkinson's Disease Risk 

  Gagliano, SA; Pouget, JG; Hardy, J; Barnes, MR; Knight, J; Ryten, M; Weale, ME (2016-11)

• Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia. 

  Hackinger, S; Prins, B; Mamakou, V; Zengini, E; Marouli, E; Brčić, L; Serafetinidis, I; Lamnissou, K; Kontaxakis, V; Dedoussis, G (2018-11-23)

  The epidemiologic link between schizophrenia (SCZ) and type 2 diabetes (T2D) remains poorly understood. Here, we investigate the presence and extent of a shared genetic background between SCZ and T2D using genome-wide ...

• The effect of CYP4F2, VKORC1 and CYP2C9 in influencing coumarin dose. A single patient data meta-analysis in more than 15,000 individuals. 

  Danese, E; Raimondi, S; Montagnana, M; Tagetti, A; Langaee, T; Borgiani, P; Ciccacci, C; Carcas, AJ; Borobia, AM; Tong, HY (2018-12-02)

  The CYP4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta-analysis at individual patients' level to capture the possible effect of ethnicity, gene-gene interaction or ...

• Predicted Benign and Synonymous Variants in CYP11A1 Cause Primary Adrenal Insufficiency Through Missplicing. 

  Maharaj, A; Buonocore, F; Meimaridou, E; Ruiz-Babot, G; Guasti, L; Peng, H-M; Capper, CP; Burgos-Tirado, N; Prasad, R; Hughes, CR (Oxford University Press, 2018-10-30)

  Primary adrenal insufficiency (PAI) is a potentially life-threatening condition that can present with nonspecific features and can be difficult to diagnose. We undertook next generation sequencing in a cohort of children ...

• Molecular targets of atypical antipsychotics: From mechanism of action to clinical differences 

  Aringhieri, S; Carli, M; Kolachalam, S; Verdesca, V; Cini, E; Rossi, M; McCormick, PJ; Corsini, GU; Maggio, R; Scarselli, M (Elsevier/Science Direct, 2018-12)

  The introduction of atypical antipsychotics (AAPs) since the discovery of its prototypical drug clozapine has been a revolutionary pharmacological step for treating psychotic patients as these allow a significant recovery ...

• Endothelial C-Type Natriuretic Peptide is a Critical Regulator of Angiogenesis and Vascular Remodeling. 

  Bubb, KJ; Aubdool, AA; Moyes, AJ; Lewis, S; Drayton, JP; Tang, O; Mehta, V; Zachary, IC; Abraham, DJ; Tsui, J (2018-12-11)

  BACKGROUND: Angiogenesis and vascular remodeling are complementary, innate responses to ischemic cardiovascular events, including peripheral artery disease (PAD) and myocardial infarction, which restore tissue blood supply ...

• The Pathogenesis of Extraintestinal Manifestations: Implications for IBD research, diagnosis and therapy. 

  Hedin, CRH; Vavricka, SR; Stagg, A; Schoepfer, A; Raine, T; Puig, L; Pleyer, U; Navarini, A; van der Meulen, A; Maul, J (2018-11-15)

• Neutrophil trafficking to lymphoid tissues: physiological and pathological implications. 

  Voisin, M-B; Nourshargh, S (2018-12-25)

  Recent advances have provided evidence for the involvement of neutrophils in both innate and adaptive immunity, robustly challenging the old dogma that neutrophils are short-lived prototypical innate immune cells solely ...

• Cardiac vagal dysfunction and myocardial injury after non-cardiac surgery: a planned secondary analysis of the measurement of Exercise Tolerance before surgery study 

  Abbott, TEF; Pearse, RM; Cuthbertson, BH; Wijeysundera, DN; Ackland, GL (2019-01-01)

  © 2018 The Author(s) Background: The aetiology of perioperative myocardial injury is poorly understood and not clearly linked to pre-existing cardiovascular disease. We hypothesised that loss of cardioprotective vagal tone ...

• The narrow-sense and common single nucleotide polymorphism heritability of early repolarization. 

  Bastiaenen, R; Nolte, IM; Munroe, PB; Riese, H; Nelson, C; O'Connor, H; Gang, Y; Warren, HR; Cabrera, C; Reinhard, W (Elsevier, 2018-10-04)

• Improving care at scale: process evaluation of a multi-component quality improvement intervention to reduce mortality after emergency abdominal surgery (EPOCH trial). 

  Stephens, TJ; Peden, CJ; Pearse, RM; Shaw, SE; Abbott, TEF; Jones, EL; Kocman, D; Martin, G; EPOCH trial group (2018-11-13)

  BACKGROUND: Improving the quality and safety of perioperative care is a global priority. The Enhanced Peri-Operative Care for High-risk patients (EPOCH) trial was a stepped-wedge cluster randomised trial of a quality ...

• Athlete's Heart: Diagnostic Challenges and Future Perspectives. 

  De Innocentiis, C; Ricci, F; Khanji, MY; Aung, N; Tana, C; Verrengia, E; Petersen, SE; Gallina, S (2018-11)

  Distinguishing between adaptive and maladaptive cardiovascular response to exercise is crucial to prevent the unnecessary termination of an athlete's career and to minimize the risk of sudden death. This is a challenging ...

• Electronic healthcare databases in Europe: descriptive analysis of characteristics and potential for use in medicines regulation. 

  Pacurariu, A; Plueschke, K; McGettigan, P; Morales, DR; Slattery, J; Vogl, D; Goedecke, T; Kurz, X; Cave, A (2018-09-05)

  OBJECTIVE: Electronic healthcare databases (EHDs) are useful tools for drug development and safety evaluation but their heterogeneity of structure, validity and access across Europe complicates the conduct of multidatabase ...

• EU-funded initiatives for real world evidence: descriptive analysis of their characteristics and relevance for regulatory decision-making. 

  Plueschke, K; McGettigan, P; Pacurariu, A; Kurz, X; Cave, A (2018-06-14)

  INTRODUCTION: A review of European Union (EU)-funded initiatives linked to 'Real World Evidence' (RWE) was performed to determine whether their outputs could be used for the generation of real-world data able to support ...

• Adverse drug reactions. 

  Ferner, RE; McGettigan, P (2018-11-06)

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