• Annexin-A1: Therapeutic Potential in Microvascular Disease 

  PURVIS, G; SOLITO, EGLE; THIEMERMANN, C (Frontiers Media, 2019-04-30)

  Annexin-A1 (ANXA1) was first discovered in the early 1980’s as a protein, which mediates (some of the) anti-inflammatory effects of glucocorticoids. Subsequently, the role of ANXA1 in inflammation has been extensively ...

• To Supplement or not to Supplement? The Rationale of Vitamin D Supplementation in Systemic Lupus Erythematosus 

  Nerviani, A; Mauro, D; Gilio, M; Grembiale, RD; Lewis, MJ (Bentham Open, 2018-12-27)

  © 2018 Nerviani et al. Background: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease characterised by abnormal activation of the immune system, chronic inflammation and organ damage. Lupus patients are ...

• The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end-points. 

  Crossland, H; Skirrow, S; Puthucheary, ZA; Constantin-Teodosiu, D; Greenhaff, PL (John Wiley & Sons Ltd on behalf of The Physiological Society, 2018-06-02)

  Loss of muscle mass and insulin sensitivity are common phenotypic traits of immobilisation and increased inflammatory burden. The suppression of muscle protein synthesis is the primary driver of muscle mass loss in human ...

• Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease. 

  Marouli, E; Del Greco, MF; Astley, CM; Yang, J; Ahmad, S; Berndt, SI; Caulfield, MJ; Evangelou, E; McKnight, B; Medina-Gomez, C (Springer Nature, 2019-03-27)

  There is evidence that lower height is associated with a higher risk of coronary artery disease (CAD) and increased risk of type 2 diabetes (T2D). It is not clear though whether these associations are causal, direct or ...

• Impact of thyroiditis on 131I uptake during ablative therapy for differentiated thyroid cancer. 

  Lim, E; Shah, S; Waterhouse, M; Akker, S; Drake, W; Plowman, N; Berney, D; Richards, P; Adams, A; Nowosinska, E (BioScientifica, 2019-04-01)

  CONTEXT: Differentiated thyroid cancer (DTC) is usually treated by thyroidectomy followed by radioiodine ablation and generally has a good prognosis. It may now be possible to limit the amount of treatment without impacting ...

• Training in cardiac computed tomography: EACVI certification process 

  Pontone, G; Moharem-Elgamal, S; Maurovich-Horvat, P; Gaemperli, O; Pugliese, F; Westwood, M; Stefanidis, A; Fox, KF; Popescu, BA (Oxford University Press (OUP), 2017-12-11)

• Coronary computed tomographic imaging in women: An expert consensus statement from the Society of Cardiovascular Computed Tomography 

  Truong, QA; Rinehart, S; Abbara, S; Achenbach, S; Berman, DS; Bullock-Palmer, R; Carrascosa, P; Chinnaiyan, KM; Dey, D; Ferencik, M (Elsevier, 2018-10-23)

  This expert consensus statement from the Society of Cardiovascular Computed Tomography (SCCT) provides an evidence synthesis on the use of computed tomography (CT) imaging for diagnosis and risk stratification of coronary ...

• Influence of Cardiac CT based disease severity and clinical symptoms on the diagnostic performance of myocardial perfusion. 

  Nissen, L; Winther, S; Westra, J; Ejlersen, JA; Isaksen, C; Rossi, A; Holm, NR; Urbonaviciene, G; Gormsen, LC; Madsen, LH (2019-04-23)

  We aimed to identify factors influencing the sensitivity of perfusion imaging after an initial positive coronary computed tomography angiography (CCTA) using invasive coronary angiography (ICA) with conditional fractional ...

• Identification of an activated neutrophil phenotype in polymyalgia rheumatica during steroid treatment: a potential involvement of immune cell cross-talk. 

  Nadkarni, S; Lashin, H; Hollywood, J; Dasgupta, B; Mason, JC; Perretti, M (2019-04-15)

  We have reported the existence of a distinct neutrophil phenotype in giant cell arteritis (GCA) patients arising at week 24 of steroid treatment. In the present study, we investigated whether longitudinal analysis of ...

• Three-dimensional echocardiographic evaluation of the right ventricle in patients with uncomplicated systemic lupus erythematosus. 

  Buonauro, A; Sorrentino, R; Esposito, R; Nappi, L; Lobasso, A; Santoro, C; Rivellese, F; Sellitto, V; Rossi, FW; Liccardo, B (Sage, 2019-03-18)

  Our aim was to identify subclinical right ventricular (RV) alterations in systemic lupus erythematosus (SLE) by combining standard and three-dimensional echocardiography (3DE). Fifty SLE patients without concomitant cardiac ...

• Circulating aryl hydrocarbon receptor-interacting protein (AIP) is independent of GH secretion. 

  Stojanovic, M; Wu, Z; Stiles, CE; Miljic, D; Soldatovic, I; Pekic, S; Doknic, M; Petakov, M; Popovic, V; Strasburger, CJ (Bioscientifica Ltd, 2019-03-04)

  BACKGROUND: Aryl hydrocarbon receptor-interacting protein (AIP) is evolutionarily conserved and expressed widely throughout the organism. Loss-of-function AIP mutations predispose to young-onset pituitary adenomas. AIP ...

• Improved lung function and patient-reported outcomes with co-suspension delivery technology glycopyrrolate/formoterol fumarate metered dose inhaler in COPD: a randomized Phase III study conducted in Asia, Europe, and the USA. 

  Lipworth, BJ; Collier, DJ; Gon, Y; Zhong, N; Nishi, K; Chen, R; Arora, S; Maes, A; Siddiqui, S; Reisner, C (Dove Medical Press Limited., 2018)

  Background: COPD is a major global cause of mortality and morbidity. PINNACLE-4 evaluated the efficacy and safety of GFF MDI (glycopyrrolate/formoterol fumarate metered dose inhaler) in patients from Asia, Europe, and the ...

• Factors influencing physical activity and rehabilitation in survivors of critical illness: a systematic review of quantitative and qualitative studies 

  Parry, SM; Knight, LD; Connolly, B; Baldwin, C; Puthucheary, Z; Morris, P; Mortimore, J; Hart, N; Denehy, L; Granger, CL (2017-04)

  Purpose: To identify, evaluate and synthesise studies examining the barriers and enablers for survivors of critical illness to participate in physical activity in the ICU and post-ICU settings from the perspective of ...

• Short- versus Long-term Dual Anti-platelet Therapy (DAPT) in Secondary Prevention for Ischaemic Stroke – A Network Metanalysis 

  PUGLIESE, F; Arasaratnam, P; Moellenberg, M; Dani, S (Oxford University Press (OUP) on behalf of the European Society of Cardiology, 2019-05-03)

  Aim: This review aimed to compare the efficacy and safety of short-term (=< 3 months) and long-term (>=1 year) dual-antiplatelet therapy (DAPT) in secondary prevention for ischaemic stroke. Methods and results: We ...

• Efficacy and Safety of Incremental Dosing of a New Single-Pill Formulation of Perindopril and Amlodipine in the Management of Hypertension. 

  Poulter, NR; Dolan, E; Gupta, AK; O'Brien, E; Whitehouse, A; Sever, PS (Springer International Publishing, 2019-03-28)

  BACKGROUND: Angiotensin-converting enzyme inhibitors and calcium channel blockers in combination are widely recommended in hypertension guidelines. The advantages of single-pill combinations (SPCs) are increasingly recognized, ...

• Danish study of Non-Invasive testing in Coronary Artery Disease 2 (Dan-NICAD 2): study design for a controlled study of diagnostic accuracy 

  PETERSEN, SE; Rasmussen, L D; Winther, S; Westra, J; Isaksen, C; Ejlersen, J A; Brix, L; Kirk, J; Urbonaviciene, G; Søndergaard, H M (Elsevier, 19-05-01)

  Background: Coronary computed tomography angiography (CTA) is the preferred primary diagnostic modality when examining patients with low to intermediate pre-test probability of coronary artery disease (CAD). Only 20-30% ...

• Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation. 

  Sun, D; Stopka-Farooqui, U; Barry, S; Aksoy, E; Parsonage, G; Vossenkämper, A; Capasso, M; Wan, X; Norris, S; Marshall, JL (2019-04-30)

  B cell lymphoma-6 (BCL6) is highly expressed in germinal center B cells, but how its expression is maintained is still not completely clear. Aryl hydrocarbon receptor interacting protein (AIP) is a co-chaperone of heat ...

• Tumor microenvironment defines the invasive phenotype of AIP-mutation-positive pituitary tumors. 

  Barry, S; Carlsen, E; Marques, P; Stiles, CE; Gadaleta, E; Berney, DM; Roncaroli, F; Chelala, C; Solomou, A; Herincs, M (2019-03-12)

  The molecular mechanisms leading to aryl hydrocarbon receptor interacting protein (AIP) mutation-induced aggressive, young-onset growth hormone-secreting pituitary tumors are not fully understood. In this study, we have ...

• Wrist ultrasound - the model method for grey-scale and power Doppler scoring. 

  Purkayastha, N; Humby, F; Rocher-Ros, V; Pitzalis, C; Kelly, S (2019-03)

• Prediction of individual life-years gained without cardiovascular events from lipid, blood pressure, glucose, and aspirin treatment based on data of more than 500 000 patients with Type 2 diabetes mellitus. 

  Berkelmans, GFN; Gudbjörnsdottir, S; Visseren, FLJ; Wild, SH; Franzen, S; Chalmers, J; Davis, BR; Poulter, NR; Spijkerman, AM; Woodward, M (Oxford University Press (OUP), 2019-01-09)

  Aims: Although group-level effectiveness of lipid, blood pressure, glucose, and aspirin treatment for prevention of cardiovascular disease (CVD) has been proven by trials, important differences in absolute effectiveness ...

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