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Recent Submissions
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Oncometabolite induced primary cilia loss in pheochromocytoma
(BioScientifica, 2018-09-01)Primary cilia are sensory organelles involved in regulation of cellular signalling. Cilia loss is frequently observed in tumors, yet the responsible mechanisms and consequences for tumorigenesis remain unclear. We demonstrate ... -
Effects of vitamin D on inflammatory and oxidative stress responses of human bronchial epithelial cells exposed to particulate matter.
(Public Library of Science, 2018-08-29)BACKGROUND: Particulate matter (PM) pollutant exposure, which induces oxidative stress and inflammation, and vitamin D insufficiency, which compromises immune regulation, are detrimental in asthma. OBJECTIVES: Mechanistic ... -
Amenamevir: Studies of Potential CYP2C8- and CYP2B6-Mediated Pharmacokinetic Interactions With Montelukast and Bupropion in Healthy Volunteers
(Wiley Periodicals, Inc. on behalf of The American College of Clinical Pharmacology, 2018-06-05)Amenamevir (formerly ASP2151) induces cytochrome P450 (CYP)2B6 and CYP3A4 and inhibits CYP2C8. We conducted 2 studies, 1 using montelukast as a probe to assess CYP2C8 and the other bupropion to assess CYP2B6. The montelukast ... -
Amenamevir: Studies of Potential CYP3A-Mediated Pharmacokinetic Interactions With Midazolam, Cyclosporine, and Ritonavir in Healthy Volunteers.
(Wiley Periodicals, Inc. on behalf of The American College of Clinical Pharmacology, 2018-07-25)Amenamevir (formerly ASP2151) is a helicase‐primase inhibitor being developed for the treatment of herpesvirus infection. Amenamevir is both a substrate and inducer of cytochrome P450 (CYP) 3A4. Three studies were done in ... -
PHP4 - Application of Multi-Criteria Decision Analysis (Mcda) Scoring as an Hta Methodology for off-Patent Pharmaceuticals (Opp) in Emerging Markets
(Elsevier, 2016-10-31)MEETING ABSTRACT PHP4 FROM ISPOR 19TH ANNUAL EUROPEAN CONGRESS RESEARCH ABSTRACTS
