RSS 1.0Clinical Pharmacology
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C-type natriuretic peptide co-ordinates cardiac structure and function.
(Oxford University Press (OUP), 2019-03-21)AIMS: C-type natriuretic peptide (CNP) is an essential endothelium-derived signalling species that governs vascular homoeostasis; CNP is also expressed in the heart but an intrinsic role for the peptide in cardiac function ... -
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals
(American Heart Association, 2017-10-13)Background— Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants ... -
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
(Nature Research (part of Springer Nature), 2017-12-22)Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which ... -
Gene Expression Integration into Pathway Modules Reveals a Pan-Cancer Metabolic Landscape
(American Association for Cancer Research, 2018-08-22)Metabolic reprogramming plays an important role in cancer development and progression and is a well-established hallmark of cancer. Despite its inherent complexity, cellular metabolism can be decomposed into functional ... -
Models of cell signaling uncover molecular mechanisms of high-risk neuroblastoma and predict disease outcome
(BioMed Central, 2018-08-22)Background: Despite the progress in neuroblastoma therapies the mortality of high-risk patients is still high (40–50%) and the molecular basis of the disease remains poorly known. Recently, a mathematical model was used ... -
Differential metabolic activity and discovery of therapeutic targets using summarized metabolic pathway models.
(Nature Research, 2019-03-01)In spite of the increasing availability of genomic and transcriptomic data, there is still a gap between the detection of perturbations in gene expression and the understanding of their contribution to the molecular ... -
The effects of death and post-mortem cold ischemia on human tissue transcriptomes
(Nature Publishing Group, 2018-02-13)Post-mortem tissues samples are a key resource for investigating patterns of gene expression. However, the processes triggered by death and the post-mortem interval (PMI) can significantly alter physiologically normal RNA ... -
Reference genome assessment from a population scale perspective: an accurate profile of variability and noise
(Oxford University Press, 2017-07-29)Motivation: Current plant and animal genomic studies are often based on newly assembled genomes that have not been properly consolidated. In this scenario, misassembled regions can easily lead to false-positive findings. ... -
High throughput estimation of functional cell activities reveals disease mechanisms and predicts relevant clinical outcomes
(Impact journals, 2016-12-22)Understanding the aspects of the cell functionality that account for disease or drug action mechanisms is a main challenge for precision medicine. Here we propose a new method that models cell signaling using biological ... -
Actionable pathways: interactive discovery of therapeutic targets using signaling pathway models
(Oxford University Press, 2016-05-02)The discovery of actionable targets is crucial for targeted therapies and is also a constituent part of the drug discovery process. The success of an intervention over a target depends critically on its contribution, within ... -
Approximate Bayesian feature selection on a large meta-dataset offers novel insights on factors that effect siRNA potency
(Oxford University Press, 2009-07-01)Motivation: Short interfering RNA (siRNA)-induced RNA interference is an endogenous pathway in sequence-specific gene silencing. The potency of different siRNAs to inhibit a common target varies greatly and features affecting ... -
Plan S: In service or disservice to society?
(Oxford University Press, 2019-03-21)The controversial plan for scientific research publications to be published in compliant Open Access Journals or on compliant Open Access Platforms is discussed. The article has been co-published with permission in European ... -
An Ectopically Expressed Serum miRNA Signature Is Prognostic, Diagnostic, and Biologically Related to Liver Allograft Rejection
(Wiley, 2016-10-05)The ability to noninvasively diagnose acute cellular rejection (ACR) with high specificity and sensitivity would significantly advance personalized liver transplant recipient care and management of immunosuppression. We ... -
Correction: Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort (vol 12, e0183732, 2017)
(Public Library of Science, 2018-02-12)The following information is omitted from the Funding section: This research has been conducted using the UK Biobank Resource under Application Number 8256 and supported in part by Medical Research Council grant MR/N025083/1. -
Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits.
(Nature Publishing Group, 2019-01-24)Genome-wide association studies (GWAS) of quantitative electrocardiographic (ECG) traits in large consortia have identified more than 130 loci associated with QT interval, QRS duration, PR interval, and heart rate (RR ... -
Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.
(Oxford University Press, 2019-01-29)An individual's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions ... -
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.
(Nature Research (part of Springer Nature), 2019-02-18)Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted ... -
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
(Nature Research (part of Springer Nature), 2018-04-09)We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10−7); of these, 16 map outside known risk-associated ... -
Differences in cardiovascular safety with non-steroidal anti-inflammatory drug therapy-A nationwide study in patients with osteoarthritis.
(2018-11-28)Osteoarthritis (OA) and the non-steroidal anti-inflammatory drugs (NSAIDs) used to relieve OA-associated pain have been linked independently to increased cardiovascular risk. We examined the risk of cardiovascular events ...
