Centre for Clinical Pharmacology
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Research in Clinical Pharmacology focuses on improving the understanding and treatment of cardiovascular disease.
Recent Submissions
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A new test for trait mean and variance detects unreported loci for blood-pressure variation.
(Elsevier, 2024-04-12)Variability in quantitative traits has clinical, ecological, and evolutionary significance. Most genetic variants identified for complex quantitative traits have only a detectable effect on the mean of trait. We have ... -
Epigenomic insights into common human disease pathology
(Springer Science and Business Media LLC, 2024-04-11)The epigenome—the chemical modifications and chromatin-related packaging of the genome—enables the same genetic template to be activated or repressed in different cellular settings. This multi-layered mechanism facilitates ... -
Prediction of atrial fibrillation and stroke using machine learning models in UK Biobank
(Elsevier, 2024-03) -
Work hours, weekend working, nonstandard work schedules and sleep quantity and quality: findings from the UK household longitudinal study.
(2024-01-27)BACKGROUND: Atypical temporal work patterns such as working longer than the standard 35-40 h/ week, weekend working, and nonstandard work schedules (i.e. outside of the typical 9-5, including but not restricted to shiftwork) ... -
The role of thyroid function in borderline personality disorder and schizophrenia: a Mendelian Randomisation study.
(2024-02-15)BACKGROUND: Genome-wide association studies have reported a genetic overlap between borderline personality disorder (BPD) and schizophrenia (SCZ). Epidemiologically, the direction and causality of the association between ... -
Personalized Antihypertensive Treatment Optimization With Smartphone-Enabled Remote Precision Dosing of Amlodipine During the COVID-19 Pandemic (PERSONAL-CovidBP Trial).
(2024-02-20)BACKGROUND: The objective of the PERSONAL-CovidBP (Personalised Electronic Record Supported Optimisation When Alone for Patients With Hypertension: Pilot Study for Remote Medical Management of Hypertension During the ... -
A Placebo-Controlled Trial of Percutaneous Coronary Intervention for Stable Angina.
(2023-12-21)BACKGROUND: Percutaneous coronary intervention (PCI) is frequently performed to reduce the symptoms of stable angina. Whether PCI relieves angina more than a placebo procedure in patients who are not receiving antianginal ... -
DHEA and response to antidepressant treatment: A Mendelian Randomization analysis
(Elsevier, 2024-02) -
The information theory of aging has not been tested.
(2024-02-29) -
Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure.
(2024-01-16)BACKGROUND: The Dietary Approaches to Stop Hypertension (DASH) diet score lowers blood pressure (BP). We examined interactions between genotype and the DASH diet score in relation to systolic BP. METHODS: We analyzed up ... -
Legacy benefits of blood pressure treatment on cardiovascular events are primarily mediated by improved blood pressure variability: the ASCOT trial.
(Oxford University Press, 2024-01-31)BACKGROUND AND AIMS: Visit-to-visit systolic blood pressure variability (BPV) is an important predictor of cardiovascular (CV) outcomes. The long-term effect of a period of blood pressure (BP) control, but with differential ...