• Exercise-Induced ATP7A, A Cu Transporter for SOD3, Restores Endothelial Dysfunction in Type2 Diabetes via Cysteine Oxidation of Protein Kinase G 

  Varadarajan, S; Abdelsaid, K; Boatwright, H; McMenamin, M; Eaton, P; Ushio-Fukai, M; Fukai, T (2022)

• A novel inhibitor of soluble Epoxide Hydrolase that adducts C521 is cardioprotective 

  Charles, R; Fernandez-Caggiano, M; Rudyk, O; Ehteramyan, M; Switzer, C; Buccafusca, R; Bianchi, K; Morales, V; Eaton, P (2022)

• Cysteine Oxidation Promotes Dimerization/Oligomerization of Circadian Protein Period 2 

  Martin Baidanoff, F; Lucia Trebucq, L; Andres Plano, S; Eaton, P; Andres Golombek, D; Jose Chiesa, J (2022)

• Abstract 14219: Oxidation of PKA-RIα Protects Against Ischemia-reperfusion Injury by Inhibiting Lysosomal-triggered Calcium Release 

  Simon, JN; VRELLAKU, B; Monterisi, S; Chu, S; Rawlings, N; Lomas, O; Marchal, GA; Waithe, D; Gajendragadkar, PR; Jayaram, R (Wolters Kluwer, 2020-11-17)

• Abstract 9930: Exercise-Induced ATP7A, A Cu Transporter for SOD3, Restores Endothelial Dysfunction in Type2 Diabetes via Cysteine Oxidation of Protein Kinase G 

  Varadarajan, S; Abdelsaid, K; Boatwright, H; McMenamin, M; Eaton, P; Ushio-Fukai, M; Fukai, T (Wolters Kluwer, 2022-11-08)

• Blood pressure lowering by nitroxyl donor CXL-1020 is mediated by oxidation of Protein Kinase G I 

  Kamynina, A; Guttzeit, S; Eaton, P; Cuello, F (2022)

• SOD1 is an essential H₂S detoxifying enzyme 

  Switzer, CH; Kasamatsu, S; Ihara, H; Eaton, P (2023)

• Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection. 

  Heusch, G; Andreadou, I; Bell, R; Bertero, E; Botker, H-E; Davidson, SM; Downey, J; Eaton, P; Ferdinandy, P; Gersh, BJ (2023-11)

  The present review summarizes the beneficial and detrimental roles of reactive oxygen species in myocardial ischemia/reperfusion injury and cardioprotection. In the first part, the continued need for cardioprotection beyond ...

• UK-5099 does not inhibit the mitochondrial pyruvate carrier through irreversible adduction to cysteine 54 in MPC2 

  Caggiano, MF; Charles, R; Prysyazhna, O; Eaton, P (Elsevier, 2023-11)

• Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation. 

  Knight, H; Abis, G; Kaur, M; Green, HLH; Krasemann, S; Hartmann, K; Lynham, S; Clark, J; Zhao, L; Ruppert, C (2023-11-13)

  BACKGROUND: Pulmonary hypertension (PH) is a chronic vascular disease characterized, among other abnormalities, by hyperproliferative smooth muscle cells and a perturbed cellular redox and metabolic balance. Oxidants induce ...

• Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci 

  de las Fuentes, L; Schwander, KL; Brown, MR; Bentley, AR; Winkler, TW; Sung, YJ; Munroe, PB; Miller, CL; Aschard, H; Aslibekyan, S

• Combining hypothesis-driven ECG indices with machine learning improves ventricular arrhythmic risk prediction in a low-risk population 

  Ramirez, J; Martinez, JP; Van Duijvenboden, S; Tinker, A; Lambiase, P; Orini, M; Munroe, PB; Miguel, A (Oxford University Press (OUP), 2023-11-09)

• Prognostic Significance of Different Ventricular Ectopic Burdens During Submaximal Exercise in Asymptomatic UK Biobank Subjects. 

  van Duijvenboden, S; Ramírez, J; Orini, M; Aung, N; Petersen, SE; Doherty, A; Tinker, A; Munroe, PB; Lambiase, PD (2023-10-19)

  BACKGROUND: The consequences of exercise-induced premature ventricular contractions (PVCs) in asymptomatic individuals remain unclear. This study aimed to assess the association between PVC burdens during submaximal exercise ...

• Long-term association of ultra-short heart rate variability with cardiovascular events. 

  Orini, M; van Duijvenboden, S; Young, WJ; Ramírez, J; Jones, AR; Hughes, AD; Tinker, A; Munroe, PB; Lambiase, PD (2023-11-03)

  Heart rate variability (HRV) is a cardiac autonomic marker with predictive value in cardiac patients. Ultra-short HRV (usHRV) can be measured at scale using standard and wearable ECGs, but its association with cardiovascular ...

• CRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny. 

  Saunderson, EA; Encabo, HH; Devis, J; Rouault-Pierre, K; Piganeau, M; Bell, CG; Gribben, JG; Bonnet, D; Ficz, G (2023-08-22)

  Aging is associated with an abnormal increase in DNA methylation (DNAm) in human gene promoters, including in bone marrow stem cells. DNAm patterns are further perturbed in hematological malignancies such as acute myeloid ...

• UK Prescribing Safety Assessment (PSA): The development, implementation and outcomes of a national online prescribing assessment. 

  Magavern, EF; Hitchings, A; Bollington, L; Wilson, K; Hepburn, D; Westacott, RJ; Sam, AH; Caulfield, MJ; Maxwell, S (2023-10-04)

  The United Kingdom (UK) Prescribing Safety Assessment (PSA) is a 2-hour online assessment of prescribing competence. It has been undertaken by students and doctors in UK medical and foundation schools for the past decade. ...

• Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension 

  Freeman, MWW; Halvorsen, Y-D; Marshall, W; Pater, M; Isaacsohn, J; Pearce, C; Murphy, B; Alp, N; Srivastava, A; Bhatt, DLL (2023)

• Development of [<SUP>18</SUP>F]AldoView as the First Highly Selective Aldosterone Synthase PET Tracer for Imaging of Primary Hyperaldosteronism 

  Sander, K; Gendron, T; Cybulska, KA; Sirindil, F; Zhou, J; Kalber, TL; Lythgoe, MF; Kurzawinski, TR; Brown, MJ; Williams, B (2021)

• Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial. 

  Mackenzie, IS; Hawkey, CJ; Ford, I; Greenlaw, N; Pigazzani, F; Rogers, A; Struthers, AD; Begg, AG; Wei, L; Avery, AJ (2022-10-08)

  BACKGROUND: Allopurinol is a urate-lowering therapy used to treat patients with gout. Previous studies have shown that allopurinol has positive effects on several cardiovascular parameters. The ALL-HEART study aimed to ...

• Baxdrostat for Treatment-Resistant Hypertension Reply 

  Freeman, MW; Halvorsen, Y-D; Brown, MJ (2023)

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