RSS 1.0Clinical Pharmacology
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Anti-platelet drugs and their necessary interaction with endothelial mediators and platelet cyclic nucleotides for therapeutic efficacy.
(Elsevier/Science Direct, 2018-08-04)For many millions of patients at secondary risk of coronary thrombosis pharmaceutical protection is supplied by dual anti-platelet therapy. Despite substantial therapeutic developments over the last decade recurrent ... -
Combination therapy as a potential risk factor for the development of type 2 diabetes in patients with schizophrenia: the GOMAP study.
(BioMed Central, 2018-08-02)BACKGROUND: Schizophrenia (SCZ) is associated with increased risk of type 2 diabetes (T2D). The potential diabetogenic effect of concomitant application of psychotropic treatment classes in patients with SCZ has not yet ... -
Sex differences in the nitrate-nitrite-NO• pathway: Role of oral nitrate-reducing bacteria.
(2018-10)Oral reduction of nitrate to nitrite is dependent on the oral microbiome and is the first step of an alternative mammalian pathway to produce nitric oxide in humans. Preliminary evidence suggests important sex differences ... -
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
(Nature Publishing Group, 2018-12-21)In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common ... -
A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis.
(2019-01)Biologic therapies have shown high efficacy in psoriasis, but individual response varies and is poorly understood. To inform biomarker discovery in the Psoriasis Stratification to Optimise Relevant Therapy (i.e., PSORT) ... -
Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients
(Springer Nature, 2018-05-25)Methotrexate (MTX) monotherapy is a common first treatment for rheumatoid arthritis (RA), but many patients do not respond adequately. In order to identify genetic predictors of response, we have combined data from two ... -
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
(Oxford University Press, 2018-09-04)More than one in three adults worldwide is either overweight or obese. Epidemiological studies indicate that the location and distribution of excess fat, rather than general adiposity, are more informative for predicting ... -
Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia.
(2018-11-23)The epidemiologic link between schizophrenia (SCZ) and type 2 diabetes (T2D) remains poorly understood. Here, we investigate the presence and extent of a shared genetic background between SCZ and T2D using genome-wide ... -
The effect of CYP4F2, VKORC1 and CYP2C9 in influencing coumarin dose. A single patient data meta-analysis in more than 15,000 individuals.
(2018-12-02)The CYP4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta-analysis at individual patients' level to capture the possible effect of ethnicity, gene-gene interaction or ... -
The narrow-sense and common single nucleotide polymorphism heritability of early repolarization.
(2019-03-15)BACKGROUND: Early repolarization (ER) is a risk marker for sudden cardiac death. Higher risk is associated with horizontal/descending ST-segment ER in the inferior or inferolateral ECG leads. Studies in family cohorts have ... -
Electronic healthcare databases in Europe: descriptive analysis of characteristics and potential for use in medicines regulation.
(2018-09-05)OBJECTIVE: Electronic healthcare databases (EHDs) are useful tools for drug development and safety evaluation but their heterogeneity of structure, validity and access across Europe complicates the conduct of multidatabase ... -
EU-funded initiatives for real world evidence: descriptive analysis of their characteristics and relevance for regulatory decision-making.
(2018-06-14)INTRODUCTION: A review of European Union (EU)-funded initiatives linked to 'Real World Evidence' (RWE) was performed to determine whether their outputs could be used for the generation of real-world data able to support ... -
Adverse drug reactions.
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Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome.
(2018-09)Background We explored the hypothesis that increased cholinergic tone exerts its proarrhythmic effects in Brugada syndrome (BrS) through increasing dispersion of transmural repolarization in patients with spontaneous and ... -
Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1).
(2018-10)BACKGROUND: Glucagon-like peptide-1 receptor (GLP-1R) agonists improve cardiovascular outcomes in patients with type 2 diabetes mellitus. However, systemic actions of these agents cause sympathetic activation, which is ... -
Foam cell formation: A new target for fighting atherosclerosis and cardiovascular disease.
(2018-08-13)During atherosclerosis, the gradual accumulation of lipids into the subendothelial space of damaged arteries results in several lipid modification processes followed by macrophage uptake in the arterial wall. The way in ...
