RSS 1.0Centre for Clinical Pharmacology
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Research in Clinical Pharmacology focuses on improving the understanding and treatment of cardiovascular disease.
Recent Submissions
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The Pharmacology of ATP-Sensitive K+ Channels (KATP).
(2021-07-11)ATP-sensitive K+ channels (KATP) are inwardly-rectifying potassium channels, broadly expressed throughout the body. KATP is regulated by adenine nucleotides, characteristically being activated by falling ATP and rising ADP ... -
A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells.
(2017-03-23)Individual human epidermal cells differ in their self-renewal ability. To uncover the molecular basis for this heterogeneity, we performed genome-wide pooled RNA interference screens and identified genes conferring a clonal ... -
Antihypertensive treatment and risk of cancer: an individual participant data meta-analysis
(Elsevier, 2021-04-02) -
Analysing electrocardiographic traits and predicting cardiac risk in UK biobank
(SAGE Publications, 2021-01-01)The electrocardiogram (ECG) is a commonly used clinical tool that reflects cardiac excitability and disease. Many parameters are can be measured and with the improvement of methodology can now be quantified in an automated ... -
JAHA Spotlight on Air Pollution and Cardiovascular Disease: A Call for Urgent Action
(American Heart Association, 2021-05-04) -
Long-Term Incidence of Stroke and Dementia in ASCOT.
(Wolters Kluwer Health, Inc on behalf of the American Heart Association, Inc, 2021-07-01)BACKGROUND AND PURPOSE: Management of stroke risk factors might reduce later dementia. In ASCOT (Anglo-Scandinavian Outcome Trial), we determined whether dementia or stroke were associated with different blood pressure ... -
COVID-19: Causes of anxiety and wellbeing support needs of healthcare professionals in the UK: A cross-sectional survey.
(Royal College of Physicians, 2021-01)BACKGROUND: COVID-19 has caused acute changes in healthcare delivery; this may impact mental health and wellbeing needs of healthcare professionals (HCPs). AIMS: We aimed to identify the causes of anxiety in HCPs during ... -
Using medical examiner case narratives to improve opioid overdose surveillance.
(Elsevier, 2018-01-30)BACKGROUND: Current opioid overdose mortality surveillance methods do not capture the complexity of the overdose epidemic. Most rely on death certificates, which may underestimate both opioid analgesic and heroin deaths. ... -
Alcohol in combination with illicit drugs among fatal injuries in Sao Paulo, Brazil: An epidemiological study on the association between acute substance use and injury.
(Elsevier, 2018-09-20)Injury deaths have a major impact on public health systems, particularly in the Latin American region; however, little is known about how different drugs, in combination or not with alcohol, interact with each injury type. ... -
Alcohol use among fatally injured victims in São Paulo, Brazil: bridging the gap between research and health services in developing countries.
(2017-04)BACKGROUND AND AIMS: Most studies reporting alcohol use among fatally injured victims are subject to bias, particularly those related to sample selection and to absence of injury context data. We developed a research method ... -
Are we looking for retinal haemorrhages?
(2019-01) -
Covid-19 and the criminalisation of viral transmission.
(2021-06-06) -
Pathological Bases and Clinical Application of Long Noncoding RNAs in Cardiovascular Diseases.
(American Heart Association, Inc., 2021-06-01)Increasing evidence has suggested that noncoding RNAs (ncRNAs) have vital roles in cardiovascular tissue homeostasis and diseases. As a main subgroup of ncRNAs, long ncRNAs (lncRNAs) have been reported to play important ... -
Neutrophil Elastase Promotes Neointimal Hyperplasia by Targeting TLR4-NFкB Signalling.
(Wiley, 2021-06-02)BACKGROUND AND PURPOSE: Neointimal hyperplasia (NIH) is the fundamental cause for vascular diseases, and vascular smooth muscle cell (VSMC) dysregulation has been widely implicated in NIH. Neutrophil elastase (NE) has been ... -
Surrogates in trials supporting European marketing authorisations of medicines for amyloidosis, cystic fibrosis, hepatitis C and idiopathic pulmonary fibrosis
(2021-03)Meeting abstract P063 from 2000 Meeting of the British-Pharmacological-Society (PHARMACOLOGY) -
The trans-ancestral genomic architecture of glycemic traits.
(2021-05-31)Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide ... -
Taxonomic variations in the gut microbiome of gout patients with and without tophi might have a functional impact on urate metabolism
(BMC, 2021-05-24)Objective: To evaluate the taxonomic composition of the gut microbiome in gout patients with and without tophi formation, and predict bacterial functions that might have an impact on urate metabolism. Methods: Hypervariable ...
