RSS 1.0Clinical Pharmacology
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EU-funded initiatives for real world evidence: descriptive analysis of their characteristics and relevance for regulatory decision-making.
(BMJ, 2018-06-18)INTRODUCTION: A review of European Union (EU)-funded initiatives linked to 'Real World Evidence' (RWE) was performed to determine whether their outputs could be used for the generation of real-world data able to support ... -
Adverse drug reactions.
(BMJ Publishing Group Ltd, 2018-11-06) -
Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome.
(American Heart Association, 2018-09-14)Background We explored the hypothesis that increased cholinergic tone exerts its proarrhythmic effects in Brugada syndrome (BrS) through increasing dispersion of transmural repolarization in patients with spontaneous and ... -
Efficacy and safety of azilsartan medoxomil/chlortalidone fixed-dose combination in hypertensive patients uncontrolled on azilsartan medoxomil alone: A randomized trial.
(2018-10-09)Patients with grade 2-3 essential hypertension and postplacebo mean clinic systolic blood pressure (SBP) 160-190 mm Hg and 24-hour SBP 140-175 mm Hg by ambulatory blood pressure monitoring (ABPM) received 40 mg azilsartan ... -
Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1).
(2018-10-11)BACKGROUND: Glucagon-like peptide-1 receptor (GLP-1R) agonists improve cardiovascular outcomes in patients with type 2 diabetes mellitus. However, systemic actions of these agents cause sympathetic activation, which is ... -
Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
(Nature America, Inc., part of Springer Nature., 2017-09-27)Erratum for Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. [Nat Genet. 2017] -
Foam cell formation: A new target for fighting atherosclerosis and cardiovascular disease.
(Elsevier Inc., 2018-08-14)During atherosclerosis, the gradual accumulation of lipids into the subendothelial space of damaged arteries results in several lipid modification processes followed by macrophage uptake in the arterial wall. The way in ... -
Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis.
(Federation of American Society of Experimental Biology (FASEB), 2018-02-20)The severity of cardiac dysfunction predicts mortality in sepsis. Activation of transient receptor potential vanilloid receptor type (TRPV)-1, a predominantly neuronal nonselective cation channel, has been shown to improve ... -
Long-term mortality after blood pressure-lowering and lipid-lowering treatment in patients with hypertension in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) Legacy study: 16-year follow-up results of a randomised factorial trial.
(Elsevier, 2018-08-26)BACKGROUND: In patients with hypertension, the long-term cardiovascular and all-cause mortality effects of different blood pressure-lowering regimens and lipid-lowering treatment are not well documented, particularly in ... -
Complete Versus Culprit-Only Lesion Intervention in Patients With Acute Coronary Syndromes.
(American College of Cardiology Foundation, 2018-10-23)BACKGROUND: A large proportion of patients presenting with non-ST-segment elevation myocardial infarction (NSTEMI) present with multivessel disease (MVD). There is uncertainty in the role of complete coronary revascularization ... -
Hypertension genomics and cardiovascular prevention.
(AME Publishing Company, 2018-08)Hypertension continues to be a major risk factor for global mortality, and recent genome-wide association studies (GWAS) have expanded in size, leading to the identification of further genetic loci influencing blood pressure. ... -
Potassium channels in the sinoatrial node and their role in heart rate control.
(Informa, 2018-10-09)Potassium currents determine the resting membrane potential and govern repolarisation in cardiac myocytes. Here, we review the various currents in the sinoatrial node focussing on their molecular and cellular properties ... -
Defective Vagal Innervation in Murine Tbx1 Mutant Hearts.
(2018-09-23)Haploinsufficiency of the T-box transcription factor TBX1 is responsible for many features of 22q11.2 deletion syndrome. Tbx1 is expressed dynamically in the pharyngeal apparatus during mouse development and Tbx1 homozygous ... -
Angiography Alone Versus Angiography Plus Optical Coherence Tomography to Guide Percutaneous Coronary Intervention: Outcomes From the Pan-London PCI Cohort.
(American College of Cardiology Foundation, 2018-07-23)OBJECTIVES: This study aimed to determine the effect on long-term survival of using optical coherence tomography (OCT) during percutaneous coronary intervention (PCI). BACKGROUND: Angiographic guidance for PCI has substantial ... -
Implementation of depression screening in antenatal clinics through tablet computers: results of a feasibility study
(BioMed Central, 2017-05-10)Background Mobile devices may facilitate depression screening in the waiting area of antenatal clinics. This can present implementation challenges, of which we focused on survey layout and technology deployment. Methods We ... -
Personalized absolute benefit of statin treatment for primary or secondary prevention of vascular disease in individual elderly patients
(Springer Link, 2016-08-23)Objective To estimate the absolute treatment effect of statin therapy on major adverse cardiovascular events (MACE; myocardial infarction, stroke and vascular death) for the individual patient aged ≥70 years. Methods ... -
Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA): a randomised double-blind placebo-controlled trial and its non-randomised non-blind extension phase.
(Elsevier, 2017-05-02)BACKGROUND: In blinded randomised controlled trials, statin therapy has been associated with few adverse events (AEs). By contrast, in observational studies, larger increases in many different AEs have been reported than ... -
Concerns related to the nocebo effect - Authors' reply.
(2017-10-21) -
Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies.
(2018-04-11)BACKGROUND: In the PATHWAY-2 study of resistant hypertension, spironolactone reduced blood pressure substantially more than conventional antihypertensive drugs. We did three substudies to assess the mechanisms underlying ... -
Comprehensive Cancer-Predisposition Gene Testing in an Adult Multiple Primary Tumor Series Shows a Broad Range of Deleterious Variants and Atypical Tumor Phenotypes
(2018-07-05)© 2018 The Authors Multiple primary tumors (MPTs) affect a substantial proportion of cancer survivors and can result from various causes, including inherited predisposition. Currently, germline genetic testing of MPT-affected ...
