RSS 1.0Clinical Pharmacology
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Recent Submissions
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Launch of mini-reviews in hot topics.
(Wiley, 2018-06-15) -
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.
(Public Library of Science, 2018-06-18)Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association ... -
ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals.
(American Heart Association, 2018-01-11)BACKGROUND: QT interval, measured through a standard ECG, captures the time it takes for the cardiac ventricles to depolarize and repolarize. JT interval is the component of the QT interval that reflects ventricular ... -
The GTN patch: a simple and effective new approach to cardioprotection?
(Springer Nature Switzerland AG., 2018-04-17)There remains a significant un-met need to reduce the extent of myocardial injury caused by ischaemia and reperfusion injury in patients experiencing an ST-elevation MI. Although nitric oxide is central to many cardioprotective ... -
Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.
(Macmillan Publishers Limited, part of Springer Nature, 2018-05-16)Impaired capacity to increase heart rate (HR) during exercise (ΔHRex), and a reduced rate of recovery post-exercise (ΔHRrec) are associated with higher cardiovascular mortality rates. Currently, the genetic basis of both ...
