Browsing William Harvey Research Institute by Issue Date
Now showing items 1-20 of 4203
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Non-invasive techniques for tracking biological aging of the cardiovascular system
(Elsevier, 08-04-2024)Population aging is one of the most important demographic transformations of our time. Increasing the “health span”—the proportion of life spent in good health—is a global priority. Biological aging comprises molecular and ... -
Evaluation of Deep Learning Estimation of Whole Heart Anatomy from Automated Cardiovascular Magnetic Resonance Short- and Long-Axis Analyses in UK Biobank
(Oxford University Press, 09-05-2024)Aims Standard methods of heart chamber volume estimation in cardiovascular magnetic resonance (CMR) typically utilize simple geometric formulae based on a limited number of slices. We aimed to evaluate whether an automated ... -
Cardiovascular magnetic resonance reference ranges from the Healthy Hearts Consortium
(Elsevier, 10-04-2024)Background The absence of population-stratified cardiovascular magnetic resonance (CMR) reference ranges from large cohorts is a major shortcoming for clinical care. Objectives This paper provides age-, sex-, and ... -
Myocardial blood flow by magnetic resonance in patients with suspected coronary stenosis: comparison to PET and invasive physiology
(American Heart Association, 18-06-2024)BACKGROUND: Despite recent guideline recommendations, quantitative perfusion (QP) estimates of myocardial blood flow from cardiac magnetic resonance (CMR) have only been sparsely validated. Furthermore, the additional ... -
A history of cardiovascular magnetic resonance imaging in clinical practice and population science
(Frontiers Media, 19-04-2024)Cardiovascular magnetic resonance (CMR) imaging has become an invaluable clinical and research tool. Starting from the discovery of nuclear magnetic resonance, this article provides a brief overview of the key developments ... -
Danish study of Non-Invasive testing in Coronary Artery Disease 2 (Dan-NICAD 2): study design for a controlled study of diagnostic accuracy
(Elsevier, 19-05-01)Background: Coronary computed tomography angiography (CTA) is the preferred primary diagnostic modality when examining patients with low to intermediate pre-test probability of coronary artery disease (CAD). Only 20-30% ... -
Distal Ventricular Pacing for Drug-Refractory Mid-Cavity Obstructive Hypertrophic Cardiomyopathy: A Randomized, Placebo-Controlled Trial of Personalized Pacing
(Lippincott, Williams & Wilkins, 19-06-2024)BACKGROUND: Patients with refractory, symptomatic left ventricular (LV) mid-cavity obstructive (LVMCO) hypertrophic cardiomyopathy have few therapeutic options. Right ventricular pacing is associated with modest hemodynamic ... -
Global Longitudinal Active Strain Energy Density (GLASED): A Powerful Prognostic Marker in a Community-Based Cohort
(Oxford University Press, 20-05-2024)Background Identifying the imaging method that best predicts all-cause mortality, cardiovascular adverse events and heart failure risk is crucial for tailoring optimal management. Potential prognostic markers include left ... -
Bone health, cardiovascular disease and imaging outcomes in UK Biobank: a causal analysis
(Oxford University Press, 25-04-2024)This study examined the association of estimated heel bone mineral density (eBMD, derived from quantitative ultrasound) with: 1) prevalent and incident cardiovascular diseases (CVDs: ischaemic heart disease (IHD), myocardial ... -
Complete amino acid sequences of variable regions of two human IgM rheumatoid factors, BOR and KAS of the Wa idiotypic family, reveal restricted use of heavy and light chain variable and joining region gene segments.
(Rockefeller University Press, 1987-08-01)Evidence derived from the complete amino acid sequences of the variable regions of both the heavy and light chains of two members (BOR and KAS) of the Wa idiotypic family of human rheumatoid factors suggests that not only ... -
Drinking among medical students: a questionnaire survey.
(1989-07-01) -
Selective expression of a VHIV subfamily of immunoglobulin genes in human CD5+ B lymphocytes from cord blood.
(Rockefeller University Press, 1991-07-01)Human B lymphocytes expressing the CD5 surface antigen (CD5+ B cells) constitute a subset capable of producing polyspecific antibodies recognizing a variety of self antigens. The repertoire of antibodies produced by CD5+ ... -
Selective autoantibody production by Yaa+ B cells in autoimmune Yaa(+)-Yaa- bone marrow chimeric mice.
(Rockefeller University Press, 1991-11-01)The accelerated autoimmune syndrome observed in BXSB/MpJ male mice is associated with the presence on the Y chromosome of an as yet unidentified mutant gene, designated Y chromosome-linked autoimmune acceleration (Yaa). ... -
Conceivable difference in the anti-inflammatory mechanisms of lipocortins 1 and 5.
(1993)Human recombinant lipocortins (LCT) 1 and 5 have been expressed in a yeast secretion vector and purified by ion exchange chromatography. The action of the proteins has been investigated in two models of experimental acute ... -
Prevention of systemic lupus erythematosus in autoimmune BXSB mice by a transgene encoding I-E alpha chain.
(1993-10-01)Males from the BXSB murine strain (H-2b) spontaneously develop an autoimmune syndrome with features of systemic lupus erythematosus (SLE), which results in part from the action of a mutant gene (Yaa) located on the Y ... -
Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome.
(1997-01-06)Interleukin-4 (IL-4) provides support for humoral immune responses through upregulation of T helper (Th) type 2 cell differentiation, but it is not known whether IL-4 promotes antibody-mediated autoimmune diseases such as ...