• C-type Natriuretic Peptide Attenuates Endothelial and Cardiac Dysfunction During Endotoxemia and Polymicrobial Sepsis 

  Moyes, A; Sand, C; Aubdool, A; Perez-Ternero, C; Mohammad, S; Thiemermann, C; Hobbs, A (2023)

• Nomenclature of Extracorporeal Blood Purification Therapies for Acute Indications: The Nomenclature Standardization Conference 

  Ostermann, M; Ankawi, G; Cantaluppi, V; Madarasu, R; Dolan, K; Husain-Syed, F; Kashani, K; Mehta, R; Prowle, J; Reis, T

• Management of regional citrate anticoagulation for continuous renal replacement therapy: guideline recommendations from Chinese emergency medical doctor consensus 

  Liu, S-Y; Xu, S-Y; Yin, L; Yang, T; Jin, K; Zhang, Q-B; Sun, F; Tan, D-Y; Xin, T-Y; Chen, Y-G (2023)

• Dynamic dosing for continuous renal replacement therapy: Service evaluation of the safety and effectiveness of titrating dose to biochemistry 

  Eldridge, JC; Shah, AB; Lucena-Amaro, S; Kirwan, CJ; Prowle, JR; Wan, YI (2023)

• Long-term disease interactions amongst surgical patients: a population cohort study. 

  Fowler, AJ; Wahedally, MAH; Abbott, TEF; Prowle, JR; Cromwell, DA; Pearse, RM (2023-08)

  BACKGROUND: The average age of the surgical population continues to increase, as does prevalence of long-term diseases. However, outcomes amongst multi-morbid surgical patients are not well described. METHODS: We included ...

• PO3_08. C-type natriuretic peptide relaxes omental arteries in a new ex vivo model of preeclampsia 

  Fato, BR; de Alwis, N; Hobbs, AJ; Kaitu'u-Lino, TJ; Bubb, KJ; Hannan, NJ (Elsevier, 2023-09)

• The metabolic effects of intermittent versus continuous feeding in critically ill patients. 

  Wilkinson, D; Gallagher, IJ; McNelly, A; Bear, DE; Hart, N; Montgomery, HE; Le Guennec, A; Conte, MR; Francis, T; Harridge, SDR (2023-11-09)

  Intermittent (or bolus) feeding regimens in critically ill patients have been of increasing interest to clinicians and scientists. Changes in amino acid, fat and carbohydrate metabolites over time might yet deliver other ...

• Inflammation and altered metabolism impede efficacy of functional electrical stimulation in critically ill patients. 

  Jameson, TSO; Caldow, MK; Stephens, F; Denehy, L; Lynch, GS; Koopman, R; Krajcova, A; Urban, T; Berney, S; Duska, F (2023-11-06)

  BACKGROUND: Critically ill patients suffer from acute muscle wasting, which is associated with significant physical functional impairment. We describe data from nested muscle biopsy studies from two trials of functional ...

• Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials. 

  LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators; Adhikari, NKJ; Hashmi, M; Tirupakuzhi Vijayaraghavan, BK; Haniffa, R; Beane, A; Webb, SA; Angus, DC; Gordon, AC; Cook, DJ (2023-10-25)

  IMPORTANCE: The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain. OBJECTIVE: To determine whether vitamin C improves outcomes for patients with COVID-19. DESIGN, SETTING, AND PARTICIPANTS: Two ...

• Hypoxemia Trajectory of Non-COVID-19 Acute Respiratory Distress Syndrome Patients. An Observational Study Focusing on Hypoxemia Resolver Status. 

  Toal, CM; Fowler, AJ; Patel, BV; Puthucheary, Z; Prowle, JR (2023-10)

  IMPORTANCE: Most studies on acute respiratory distress syndrome (ARDS) group patients by severity based on their initial degree of hypoxemia. However, this grouping has limitations, including inconsistent hypoxemia ...

• C-type natriuretic peptide protects against the development of non-alcoholic steatohepatitis and portal hypertension 

  Perez-Ternero, C; Li, W; Aubdool, A; Goldin, R; Alazawi, W; Hobbs, A (2023)

• METFORMIN TREATMENT IMPROVES LYMPHOCYTE METABOLISM IN A MOUSE MODEL OF MAJOR SURGERY 

  Jones, TF; del Arroyo, AG; Henson, SM; Ackland, GL (2021)

• Human neutrophils communicate remotely via calcium-dependent glutamate-induced glutamate release 

  Kopach, O; Sylantyev, S; Bard, L; Michaluk, P; Heller, JP; del Arroyo, AG; Ackland, GL; Gourine, AV; Rusakov, DA (2023)

• One-year outcomes after discharge from noncardiac surgery and association between pre-discharge complications and death after discharge: analysis of the VISION prospective cohort study. 

  Roshanov, PS; Chan, MTV; Borges, FK; Conen, D; Wang, CY; Xavier, D; Berwanger, O; Marcucci, M; Sessler, DI; Szczeklik, W (2023-09-15)

  BACKGROUND: In prior analyses, myocardial injury after noncardiac surgery, major bleeding, and sepsis were independently associated with most deaths in the 30 days after noncardiac surgery, but most of these deaths occurred ...

• Immediate and sustained increases in the activity of vagal preganglionic neurons during exercise and after exercise training. 

  Korsak, A; Kellett, DO; Aziz, Q; Anderson, C; D'Souza, A; Tinker, A; Ackland, GL; Gourine, AV (2023-10-24)

  AIMS: The brain controls the heart by dynamic recruitment and withdrawal of cardiac parasympathetic (vagal) and sympathetic activity. Autonomic control is essential for the development of cardiovascular responses during ...

• Heart rate recovery after orthostatic challenge and cardiopulmonary exercise testing in older individuals: prospective multicentre observational cohort study 

  James, A; Bruce, D; Tetlow, N; Patel, ABU; Black, E; Whitehead, N; Ratcliff, A; Jamie Humphreys, A; MacDonald, N; McDonnell, G (Elsevier BV, 2023-12)

• Discontinuation vs. continuation of renin-angiotensin system inhibition before non-cardiac surgery: the SPACE trial. 

  Ackland, GL; Patel, A; Abbott, TEF; Begum, S; Dias, P; Crane, DR; Somanath, S; Middleditch, A; Cleland, S; Gutierrez Del Arroyo, A (2023-11-07)

  BACKGROUND AND AIMS: Haemodynamic instability is associated with peri-operative myocardial injury, particularly in patients receiving renin-angiotensin system (RAS) inhibitors (angiotensin-converting-enzyme inhibitors/angiotensin ...

• Early Intravenous Beta-Blockade with Esmolol in Adults with Severe Traumatic Brain Injury (EBB-TBI): Protocol for a Phase 2a Intervention Design Study 

  Thomas, M; Hayes, K; White, P; Ramesh, A; Culliford, L; Ackland, G; Pickering, A (2023)

• Study protocol for IMPRoVE: a multicentre prospective observational cohort study of the incidence, impact and mechanisms of perioperative right ventricular dysfunction in non-cardiac surgery. 

  Keast, T; McErlane, J; Kearns, R; McKinlay, S; Raju, I; Watson, M; Robertson, KE; Berry, C; Greenlaw, N; Ackland, G (2023-09-06)

  INTRODUCTION: Perioperative myocardial injury evidenced by elevated cardiac biomarkers (both natriuretic peptides and troponin) is common after major non-cardiac surgery. However, it is unclear if the rise in cardiac ...

• Intramuscular inflammation and altered substrate utilisation may impede intervention efficacy in critically ill patients: Nested sub-studies in Functional Electrical Stimulation trials 

  Puthucheary, Z

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