• THE FES GENE, LOCATED AT THE CHROMOSOME 15Q21.6 CORONARY-ARTERY-DISEASE LOCUS, MODULATES ATHEROSCLEROTIC PLAQUE VULNERABILITY 

  Karamanavi, E; Mcvey, DG; Van der Laan, SW; Yang, W; Chan, K; Poston, RN; Jones, PD; Kostogrys, RB; Webb, TR; Pasterkamp, G (2020-12)

• Transplantation of Skeletal Muscle-Derived Sca-1(+)/PW1(+)/Pax7(-) Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction 

  Ruchaya, PJ; Lewis-McDougall, FCC; Sornkarn, N; Amin, S; Grimsdell, B; Shaalan, A; Gritti, G; Soe, KT; Clark, JEE; Ellison-Hughes, GMM (2022-12)

• Proximity proteomics identifies septins and PAK2 as decisive regulators of actomyosin-mediated expulsion of von Willebrand factor 

  El-Mansi, S; Robinson, CL; Kostelnik, KB; McCormack, JJ; Mitchell, TP; Lobato-Marquez, D; Rajeeve, V; Cutillas, P; Cutler, DF; Mostowy, S (2023-02-23)

• Genome wide CRISPR/Cas9 screen identifies the coagulation factor IX (F9) as a regulator of senescence 

  Carpintero-Fernandez, P; Borghesan, M; Eleftheriadou, O; Pan-Castillo, B; Antonio Fafian-Labora, J; Mitchell, TP; Yuste, A; Ogrunc, M; Nightingale, TD; Mayan, M (2022-02-19)

• Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A 

  Joulia, R; Guerrero-Fonseca, IM; Girbl, T; Coates, JA; Stein, M; Vazquez-Martinez, L; Lynam, E; Whiteford, J; Schnoor, M; Voehringer, D (2022-11-17)

• Receptor tyrosine kinase inhibitors negatively impact on pro-reparative characteristics of human cardiac progenitor cells 

  Smith, AJ; Ruchaya, P; Walmsley, R; Wright, KE; Lewis-McDougall, FC; Bond, J; Ellison-Hughes, GM (2022-06-16)

• A degradatory fate for CCR4 suggests a primary role in Th2 inflammation. 

  Anderson, CA; Patel, P; Viney, JM; Phillips, RM; Solari, R; Pease, JE (2020-03)

  CCR4 is the sole receptor for the chemokines CCL22 and CCL17. Clinical studies of asthmatic airways have shown levels of both ligands and CCR4+ Th2 cells to be elevated, suggestive of a role in disease. Consequently, CCR4 ...

• Roles of Syndecan-4 in cardiac injury and repair 

  Shaik, F; Michaela; Balderstone, JM; Arokiasamy, S; Whiteford, JR (2022-05)

• Endothelial cell autophagy keeps neutrophil trafficking under control 

  Reglero-Real, N; Perez-Gutierrez, L; Nourshargh, S (2021-12-02)

• Tracking changes between preprint posting and journal publication during a pandemic 

  Brierley, L; Nanni, F; Polka, JK; Dey, G; Palfy, M; Fraser, N; Coates, JA (2022-02)

• Syndecan receptors: pericellular regulators in development and inflammatory disease. 

  Gopal, S; Arokiasamy, S; Pataki, C; Whiteford, JR; Couchman, JR (The Royal Society, 2021-02-10)

  The syndecans are the major family of transmembrane proteoglycans, usually bearing multiple heparan sulfate chains. They are present on virtually all nucleated cells of vertebrates and are also present in invertebrates, ...

• Pathological Angiogenesis Requires Syndecan-4 for Efficient VEGFA-Induced VE-Cadherin Internalization 

  De Rossi, G; Vahatupa, M; Cristante, E; Arokiasamy, S; Liyanage, SE; May, U; Pellinen, L; Uusitalo-Jarvinen, H; Bainbridge, JW; Jarvinen, TAH (American Heart Association, 2021-02-18)

  Objective: VEGFA (Vascular endothelial growth factor A) and its receptor VEGFR2 (vascular endothelial growth factor receptor 2) drive angiogenesis in several pathologies, including diabetic retinopathy, wet age-related ...

• Cardiovascular Progerin Suppression and lamin A Restoration Rescues Hutchinson-Gilford Progeria Syndrome. 

  Sánchez-López, A; Espinós-Estévez, C; González-Gómez, C; Gonzalo, P; Andrés-Manzano, MJ; Fanjul, V; Riquelme-Borja, R; Hamczyk, MR; Macías, Á; Del Campo, L (Wolters Kluwer Health, Inc., 2021-10-25)

  Background: Hutchinson-Gilford progeria syndrome (HGPS) is a rare disorder characterized by premature aging and death mainly due to myocardial infarction, stroke, or heart failure. The disease is provoked by progerin, a ...

• Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation 

  Reglero, N; Pérez-Gutiérrez, L; Yoshimura, A; Rolas, L; Garrido-Mesa, J; Barkaway, A; PICKWORTH, C; Saleeb, R; Gonzalez-Nuñez, M; Austin-Williams, SN (Elsevier, 2021-08-06)

  The migration of neutrophils from the blood circulation to sites of infection or injury is a key immune response and requires the breaching of endothelial cells (ECs) that line the inner aspect of blood vessels. ...

• The dimeric form of CXCL12 binds to atypical chemokine receptor 1 

  Gutjahr, JC; Crawford, KS; Jensen, DR; Naik, P; Peterson, FC; Samson, GPB; Legler, DF; Duchene, J; Veldkamp, CT; Rot, A (American Association for the Advancement of Science (AAAS), 2021-08-17)

  The pleiotropic chemokine CXCL12 is involved in diverse physiological and pathophysiological processes, including embryogenesis, hematopoiesis, leukocyte migration, and tumor metastasis. It is known to engage the classical ...

• Functional and clinical relevance of VLA-4 (CD49d/CD29) in ibrutinib-treated chronic lymphocytic leukemia 

  Tissino, E; Benedetti, D; Herman, SEM; ten Hacken, E; Ahn, IE; Chaffee, KG; Rossi, FM; Dal Bo, M; Bulian, P; Bomben, R (2018-02)

• CD44 loss of function sensitizes AML cells to the BCL-2 inhibitor venetoclax by decreasing CXCL12-driven survival cues. 

  Yu, X; Munoz-Sagredo, L; Streule, K; Muschong, P; Bayer, E; Walter, RJ; Gutjahr, JC; Greil, R; Concha, ML; Müller-Tidow, C (2021-06-03)

  Acute myeloid leukemia (AML) has a poor prognosis under the current standard of care. In recent years, venetoclax, a BCL-2 inhibitor, was approved to treat patients, ineligible for intensive induction chemotherapy. Complete ...

• CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity. 

  Gutjahr, JC; Bayer, E; Yu, X; Laufer, JM; Höpner, JP; Tesanovic, S; Härzschel, A; Auer, G; Rieß, T; Salmhofer, A (Ferrata Storti Foundation, 2020-07-02)

  Adhesive properties of leukemia cells shape the degree of organ infiltration and the extent of leukocytosis. CD44 and the integrin VLA-4, a CD49d/CD29 heterodimer, are important factors of progenitor cell adhesion in bone ...

• The role of CD44 in the pathophysiology of chronic lymphocytic leukemia 

  Gutjahr, JC; Greil, R; Hartmann, TN (Frontiers Media, 2015-04-20)

  CD44 interactions with hyaluronan (HA) play a key role in various malignancies, supporting tumor cell migration, adhesion, and survival. In contrast to solid tumors, the expression of CD44 standard and variant forms and ...

• TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia 

  Catakovic, K; Gassner, FJ; Ratswohl, C; Zaborsky, N; Rebhandl, S; Schubert, M; Steiner, M; Gutjahr, JC; Pleyer, L; Egle, A (Taylor & Francis, 2017-09-21)

  While research on T cell exhaustion in context of cancer particularly focuses on CD8C cytotoxic T cells, the role of inhibitory receptors on CD4C T-helper cells have remained largely unexplored. TIGIT is a recently identified ...

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