Centre for Microvascular Research (CMR)
Browse by
Recent Submissions
-
Roles of the lamin A-specific tail region in the localization to sites of nuclear envelope rupture.
(Oxford University Press, 2024-12)The nuclear lamina (NL) lines the nuclear envelope (NE) to maintain nuclear structure in metazoan cells. The major NL components, the nuclear lamins contribute to the protection against NE rupture induced by mechanical ... -
Nrg1/ErbB signaling-mediated regulation of fibrosis after myocardial infarction.
(Wiley, 2022-01-08)Appropriate fibrotic tissue formation after myocardial infarction (MI) is crucial to the maintenance of the heart's structure. M2-like macrophages play a vital role in post-MI fibrosis by activating cardiac fibroblasts. ... -
Effect of mechanical tension on fibroblast transcriptome profile and regulatory mechanisms of myocardial collagen turnover.
(Wiley, 2023-03-01)Excess deposition of extracellular matrix in the myocardium is a predictor of reduced left ventricular function. Although reducing the hemodynamic load is known to improve myocardial fibrosis, the mechanisms underlying the ... -
Immunocompetent cells in durable ventricular assist device-implanted non-ischaemic dilated cardiomyopathy.
(Springer Nature, 2022-02-28)OBJECTIVE: Because the presence of immunocompetent cells in the myocardium is associated with the pathological stage and/or myocardial viability, we explored relationships between functional recovery after left ventricular ... -
QM107, a novel CD148 (RTP Type J) activating peptide therapy for treating neovascular age-related macular degeneration.
(Wiley, 2024-10-20)BACKGROUND AND PURPOSE: Angiogenesis is a pathological component of neovascular age-related macular degeneration. Current therapies, although successful, are prone to high levels of patient non-response and a loss of ... -
Regulation of ICAM-1 in human neutrophils.
(2024-04-16)Intercellular cell adhesion molecule 1 (ICAM-1) is a cell surface glycoprotein with a vital role in the immune response to pathogens. The expression pattern of ICAM-1 is wide-ranging, encompassing endothelial cells, ... -
Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues
(EMBO Press, 2024-06-25)Cellular senescence is a hallmark of advanced age and a major instigator of numerous inflammatory pathologies. Whilst endothelial cell (EC) senescence is aligned with defective vascular functionality, its impact on fundamental ... -
Myosin-1C augments secretion of von Willebrand factor by linking contractile actomyosin machinery to the plasma membrane.
(American Society of Hematology (ASH Publications), 2024-04-26)Blood endothelial cells control the hemostatic and inflammatory response by secreting von Willebrand factor (VWF) and P-selectin from storage organelles called Weibel-Palade bodies (WPB). Actin-associated motor proteins ... -
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
(eLife, 2024-04-10)Epithelial intercellular adhesion molecule (ICAM)-1 is apically polarized, interacts with, and guides leukocytes across epithelial barriers. Polarized hepatic epithelia organize their apical membrane domain into bile ... -
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
(eLife Sciences Publications, Ltd, 2024-04-10)Epithelial intercellular adhesion molecule (ICAM)-1 is apically polarized, interacts with, and guides leukocytes across epithelial barriers. Polarized hepatic epithelia organize their apical membrane domain into bile ... -
Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells
Hutchinson-Gilford progeria syndrome (HGPS) is a rare disease caused by the expression of progerin, a mutant protein that accelerates aging and precipitates death. Given that atherosclerosis complications are the main cause ...