Centre for Biochemical Pharmacology
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β1-Integrin-Mediated Uptake of Chondrocyte Extracellular Vesicles Regulates Chondrocyte Homeostasis.
(MDPI, 2024-04-26)Osteoarthritis (OA) is the most prevalent age-related degenerative disorder, which severely reduces the quality of life of those affected. Whilst management strategies exist, no cures are currently available. Virtually all ... -
Impact of comorbidities on EQ5D quality of life index in severe asthma
(Elsevier, 2024-05-31) -
Exploring definitions and predictors of response to biologics for severe asthma.
(Elsevier, 2024-05-19)BACKGROUND: Biologic effectiveness is often assessed as 'response', a term which eludes consistent definition. Identifying those most likely to respond in real-life has proven challenging. OBJECTIVE: To explore definitions ... -
Exploring Definitions and Predictors of Severe Asthma Clinical Remission Post-Biologic in Adults.
(American Thoracic Society, 2024-05-03)RATIONALE: There is no consensus on criteria to include in an asthma remission definition in real-life. Factors associated with achieving remission post-biologic-initiation remain poorly understood. OBJECTIVES: To quantify ... -
Innate and adaptive immunity in acute myocarditis.
(2024-06-01)Acute myocarditis is an acute inflammatory cardiomyopathy associated with cardiac damage triggered by a virus or a pathological immune activation. It may present with a wide range of clinical presentations, ranging from ... -
Being old and female is an inflammatory combination.
(2023-09-27) -
Efferocyte-Derived MCTRs Metabolically Prime Macrophages for Continual Efferocytosis via Rac1-Mediated Activation of Glycolysis.
(2023-12-08)Clearance of multiple rounds of apoptotic cells (ACs) through continual efferocytosis is critical in the maintenance of organ function, the resolution of acute inflammation, and tissue repair. To date, little is known about ... -
Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma.
(2023-11-28)RATIONALE: Previous studies investigating comorbidity impact on biologic effectiveness have been relatively small, of short duration, and have not compared biologic classes. OBJECTIVES: To determine the association between ... -
A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing.
(2023-05-25)BACKGROUND: Many genes associated with asthma explain only a fraction of its heritability. Most genome-wide association studies (GWASs) used a broad definition of 'doctor-diagnosed asthma', thereby diluting genetic signals ...