William Harvey Research Institute: Recent submissions
Now showing items 1-20 of 2684
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Expression of ACKR4 demarcates the "peri-marginal sinus," a specialized vascular compartment of the splenic red pulp.
(2021-07-13)The spleen comprises defined microanatomical compartments that uniquely contribute to its diverse host defense functions. Here, we identify a vascular compartment within the red pulp of the spleen delineated by expression ... -
Multidrug resistance proteins preferentially regulate natriuretic peptide-driven cGMP signalling in the heart & vasculature.
(2021-06-15)BACKGROUND & PURPOSE: Cyclic-3',5'-guanosine monophosphate (cGMP) underpins the bioactivity of nitric oxide (NO) and natriuretic peptides and is key to cardiovascular homeostasis. Cyclic GMP-driven responses are terminated ... -
Head and neck cancer surgery during the COVID-19 pandemic: An international, multicenter, observational cohort study.
(Wiley Periodicals LLC on behalf of American Cancer Society, 2021-07-15)BACKGROUND: The aims of this study were to provide data on the safety of head and neck cancer surgery currently being undertaken during the coronavirus disease 2019 (COVID-19) pandemic. METHODS: This international, ... -
Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses.
(Frontiers Media, 2021-06-15)Passive immunization using monoclonal antibodies will play a vital role in the fight against COVID-19. The recent emergence of viral variants with reduced sensitivity to some current antibodies and vaccines highlights the ... -
The Pharmacology of ATP-Sensitive K+ Channels (KATP).
(2021-07-11)ATP-sensitive K+ channels (KATP) are inwardly-rectifying potassium channels, broadly expressed throughout the body. KATP is regulated by adenine nucleotides, characteristically being activated by falling ATP and rising ADP ... -
Changes in brown adipose tissue lipid mediator signatures with aging, obesity, and DHA supplementation in female mice
(Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology (FASEB)., 2021-05-07)Brown adipose tissue (BAT) dysfunction in aging and obesity has been related to chronic unresolved inflammation, which could be mediated by an impaired pro-duction of specialized proresolving lipid mediators (SPMs), such ... -
AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVO
(2021-05-19) -
TLRs toll for Tregs.
(2019-12)Discussion on TLR3 triggering in CD4 T cells induces IFN beta and IL10-producing iTregs that suppress food allergy. -
A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells.
(2017-03-23)Individual human epidermal cells differ in their self-renewal ability. To uncover the molecular basis for this heterogeneity, we performed genome-wide pooled RNA interference screens and identified genes conferring a clonal ... -
Antihypertensive treatment and risk of cancer: an individual participant data meta-analysis
(Elsevier, 2021-04-02) -
GHRH secretion from a pancreatic neuroendocrine tumor causing gigantism in a patient with MEN1.
(2021-06-01)Summary: A male patient with a germline mutation in MEN1 presented at the age of 18 with classical features of gigantism. Previously, he had undergone resection of an insulin-secreting pancreatic neuroendocrine tumour ...
