William Harvey Research Institute: Recent submissions
Now showing items 1-20 of 754
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Combination therapy as a potential risk factor for the development of type 2 diabetes in patients with schizophrenia: the GOMAP study.
(BioMed Central, 2018-08-02)BACKGROUND: Schizophrenia (SCZ) is associated with increased risk of type 2 diabetes (T2D). The potential diabetogenic effect of concomitant application of psychotropic treatment classes in patients with SCZ has not yet ... -
Independent Left Ventricular Morphometric Atlases Show Consistent Relationships with Cardiovascular Risk Factors: A UK Biobank Study
(Nature Publishing Group, 2019-02-04)Left ventricular (LV) mass and volume are important indicators of clinical and pre-clinical disease processes. However, much of the shape information present in modern imaging examinations is currently ignored. Morphometric ... -
Part I: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Study Design and Humane Modeling Endpoints.
(Wolters Kluwer Health, Inc., 2019-01-01)Preclinical animal studies are mandatory before new treatments can be tested in clinical trials. However, their use in developing new therapies for sepsis has been controversial because of limitations of the models and ... -
Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis
(Springer Berlin Heidelberg, 2018-09-17)Correction to: Infection https://doi.org/10.1007/s15010-018-1183-8 The original version of this article unfortunately contained mistakes. The Tables 1–3 were missing. The correct versions of Tables 1, 2 and 3 are given ... -
Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis
(Springer Berlin Heidelberg, 2018-08-14)Purpose: Pre-clinical animal studies precede the majority of clinical trials. While the clinical sepsis definitions and recommended treatments are regularly updated, a systematic review of pre-clinical models of sepsis ... -
Impaired Production and Diurnal Regulation of Vascular RvDn-3 DPA Increase Systemic Inflammation and Cardiovascular Disease.
(Wolters Kluwer Health, Inc on behalf of American Heart Association, 2018-03-16)RATIONALE: Diurnal mechanisms are central to regulating host responses. Recent studies uncovered a novel family of mediators termed as specialized proresolving mediators that terminate inflammation without interfering with ... -
Mesenchymal Stem/Stromal Cell-Based Therapy for Heart Failure - What Is the Best Source?
(Japanese Circulation Society, 2018-08-24)Transplantation of stem/progenitor cells is a promising, emerging treatment for heart failure (HF) in the modern era. Mesenchymal stem/stromal cells (MSCs) are considered as one of the most promising cell sources for this ... -
Cardiac Vagus and Exercise.
(American Physiological Society, 2019-01-01)Lower resting heart rate and high autonomic vagal activity are strongly associated with superior exercise capacity, maintenance of which is essential for general well-being and healthy aging. Recent evidence obtained in ... -
Sex differences in the nitrate-nitrite-NO• pathway: Role of oral nitrate-reducing bacteria.
(2018-10)Oral reduction of nitrate to nitrite is dependent on the oral microbiome and is the first step of an alternative mammalian pathway to produce nitric oxide in humans. Preliminary evidence suggests important sex differences ... -
Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1n-3 DPA.
(2018-12-04)New drugs that can resolve inflammation without immunosuppressive effects are at the medicinal chemistry frontier. Pro-resolving endogenously formed small molecules, that is, the resolvins, are excellent candidates displaying ... -
Authors' Reply to Kindermann et al.'s Comment on: "Athlete's Heart: Diagnostic Challenges and Future Perspectives".
(Springer Link, 2019-01-08)We thank Prof. Wilfried Kindermann and colleagues for their interest in our publication [1] and for the important comments raised in their letter [2]. They understandably underscore the importance of a step-wise approach ... -
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
(Nature Publishing Group, 2018-12-21)In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common ... -
Pseudoacromegaly
(Elsevier/Science Direct, 2018-11-15)© 2018 Elsevier Inc. Individuals with acromegaloid physical appearance or tall stature may be referred to endocrinologists to exclude growth hormone (GH) excess. While some of these subjects could be healthy individuals ... -
A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis.
(2019-01)Biologic therapies have shown high efficacy in psoriasis, but individual response varies and is poorly understood. To inform biomarker discovery in the Psoriasis Stratification to Optimise Relevant Therapy (i.e., PSORT) ... -
Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients
(Springer Nature, 2018-05-25)Methotrexate (MTX) monotherapy is a common first treatment for rheumatoid arthritis (RA), but many patients do not respond adequately. In order to identify genetic predictors of response, we have combined data from two ... -
Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury.
(Wiley, 2019-01-11)Ischemia/reperfusion (I/R) injury is a severe inflammatory insult associated with numerous pathologies such as myocardial infarction, stroke and acute kidney injury. I/R injury is characterized by a rapid influx of activated ... -
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
(Oxford University Press, 2018-09-04)More than one in three adults worldwide is either overweight or obese. Epidemiological studies indicate that the location and distribution of excess fat, rather than general adiposity, are more informative for predicting ... -
Nicotinamide Nucleotide Transhydrogenase as a Novel Treatment Target in Adrenocortical Carcinoma.
(2018-08-01)Adrenocortical carcinoma (ACC) is an aggressive malignancy with poor response to chemotherapy. In this study, we evaluated a potential new treatment target for ACC, focusing on the mitochondrial reduced form of NAD phosphate ... -
Feasibility of real-time capture of routine clinical data in the electronic health record: a hospital-based, observational service-evaluation study.
(2018-03-08)OBJECTIVES: The electronic health record (EHR) is underused in the hospital setting. The aim of this service evaluation study was to respond to National Health Service (NHS) Digital's ambition for a paperless NHS by capturing ...
