William Harvey Research Institute: Recent submissions
Now showing items 1-20 of 1195
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Rectus Femoris Cross-Sectional Area and Muscle Layer Thickness: Comparative Markers of Muscle Wasting and Weakness.
(American Thoracic Society, 2017-01-01)To the Editor: Muscle wasting during critical illness has been suggested to contribute to survivor functional disability (1). Two B-mode ultrasound measures have been reported that quantify wasting (2, 3): (1) combined ... -
Proteomic Analysis of the Human Anterior Pituitary Gland.
(Mary Ann Liebert, 2018-12-20)The pituitary function is regulated by a complex system involving the hypothalamus and biological networks within the pituitary. Although the hormones secreted from the pituitary have been well studied, comprehensive ... -
Vitamin D Counteracts an IL-23-Dependent IL-17A+IFN-γ+ Response Driven by Urban Particulate Matter.
(American Thoracic Society, 2017-09-01)Urban particulate matter (UPM) air pollution and vitamin D deficiency are detrimentally associated with respiratory health. This is hypothesized to be due in part to regulation of IL-17A, which UPM is reported to promote. ... -
C-type natriuretic peptide co-ordinates cardiac structure and function.
(Oxford University Press (OUP), 2019-03-21)AIMS: C-type natriuretic peptide (CNP) is an essential endothelium-derived signalling species that governs vascular homoeostasis; CNP is also expressed in the heart but an intrinsic role for the peptide in cardiac function ... -
Automated quality control in image segmentation: application to the UK Biobank cardiovascular magnetic resonance imaging study
(BioMed Central, 2019-03-14)Background: The trend towards large-scale studies including population imaging poses new challenges in terms of quality control (QC). This is a particular issue when automatic processing tools such as image segmentation methods ... -
The ASOS Surgical Risk Calculator: development and validation of a tool for identifying African surgical patients at risk of severe postoperative complications
(Elsevier, 2018-09-17)Background: The African Surgical Outcomes Study (ASOS) showed that surgical patients in Africa have a mortality twice the global average. Existing risk assessment tools are not valid for use in this population because the ... -
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals
(American Heart Association, 2017-10-13)Background— Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants ... -
The Bare Minimum: The Reality of Global Anaesthesia and Patient Safety
(Springer International Publishing, 2016-06-01) -
Connections of annexin A1 and translocator protein-18 kDa on toll like receptor stimulated BV-2 cells.
(Elsevier/Science Direct, 2018-04-09)BACKGROUND: Annexin A1 (ANXA1) and Translocator Protein-18KDa (TSPO) down-regulate neuroinflammation. We investigated the role of recombinant ANXA1 (rANXA) on TSPO functions on Toll Like Receptor (TLR) activated microglia. ... -
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
(Nature Research (part of Springer Nature), 2017-12-22)Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which ... -
Physical activity and left-ventricular trabeculation in the UK Biobank community-based cohort study
(BMJ Publishing Group, 2019-02-05)Objective: Vigorous physical activity (PA) in highly trained athletes has been associated with heightened left ventricular (LV) trabeculation extent. It has therefore been hypothesised that LV trabeculation extent may ... -
Gene Expression Integration into Pathway Modules Reveals a Pan-Cancer Metabolic Landscape
(American Association for Cancer Research, 2018-08-22)Metabolic reprogramming plays an important role in cancer development and progression and is a well-established hallmark of cancer. Despite its inherent complexity, cellular metabolism can be decomposed into functional ... -
Lipid Mediator Metabolomics Via LC-MS/MS Profiling and Analysis.
(2018)Solid-phase extraction coupled with liquid chromatography tandem mass spectrometry provides a robust and sensitive approach for the identification and quantitation of specialized pro-resolving mediators (lipoxins, resolvins, ... -
Validity of a two-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis
(Oxford University Press on behalf of the British Society for Rheumatology., 2018-04-25)Objectives. Imaging of joint inflammation provides a standard against which to derive an updated DAS for RA. Our objectives were to develop and validate a DAS based on reweighting the DAS28 components to maximize ... -
Polycystins are required for primary cilia-mediated mechanotransduction in chondrocytes
(Wiley, 2017-05-30)Meeting abstract from British Society for Matrix Biology Autumn 2016 Meeting: The Art of Communication – Signalling Cascades in Mechanotransduction -
Models of cell signaling uncover molecular mechanisms of high-risk neuroblastoma and predict disease outcome
(BioMed Central, 2018-08-22)Background: Despite the progress in neuroblastoma therapies the mortality of high-risk patients is still high (40–50%) and the molecular basis of the disease remains poorly known. Recently, a mathematical model was used ... -
Differential metabolic activity and discovery of therapeutic targets using summarized metabolic pathway models.
(Nature Research, 2019-03-01)In spite of the increasing availability of genomic and transcriptomic data, there is still a gap between the detection of perturbations in gene expression and the understanding of their contribution to the molecular ... -
The effects of death and post-mortem cold ischemia on human tissue transcriptomes
(Nature Publishing Group, 2018-02-13)Post-mortem tissues samples are a key resource for investigating patterns of gene expression. However, the processes triggered by death and the post-mortem interval (PMI) can significantly alter physiologically normal RNA ... -
Reference genome assessment from a population scale perspective: an accurate profile of variability and noise
(Oxford University Press, 2017-07-29)Motivation: Current plant and animal genomic studies are often based on newly assembled genomes that have not been properly consolidated. In this scenario, misassembled regions can easily lead to false-positive findings. ... -
High throughput estimation of functional cell activities reveals disease mechanisms and predicts relevant clinical outcomes
(Impact journals, 2016-12-22)Understanding the aspects of the cell functionality that account for disease or drug action mechanisms is a main challenge for precision medicine. Here we propose a new method that models cell signaling using biological ...
