RSS 1.0Centre for Endocrinology
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Impact of thyroiditis on 131I uptake during ablative therapy for differentiated thyroid cancer.
(BioScientifica, 2019-04-01)CONTEXT: Differentiated thyroid cancer (DTC) is usually treated by thyroidectomy followed by radioiodine ablation and generally has a good prognosis. It may now be possible to limit the amount of treatment without impacting ... -
Circulating aryl hydrocarbon receptor-interacting protein (AIP) is independent of GH secretion.
(Bioscientifica Ltd, 2019-03-04)BACKGROUND: Aryl hydrocarbon receptor-interacting protein (AIP) is evolutionarily conserved and expressed widely throughout the organism. Loss-of-function AIP mutations predispose to young-onset pituitary adenomas. AIP ... -
Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation.
(2019-04-30)B cell lymphoma-6 (BCL6) is highly expressed in germinal center B cells, but how its expression is maintained is still not completely clear. Aryl hydrocarbon receptor interacting protein (AIP) is a co-chaperone of heat ... -
Tumor microenvironment defines the invasive phenotype of AIP-mutation-positive pituitary tumors.
(2019-03-12)The molecular mechanisms leading to aryl hydrocarbon receptor interacting protein (AIP) mutation-induced aggressive, young-onset growth hormone-secreting pituitary tumors are not fully understood. In this study, we have ... -
Prevalence of Diabetes on Santa Cruz Island in Galapagos Archipelago.
(2015-06-18)This was an observational study offering a screening program for diabetes in a health clinic in Puerto Ayora town on Santa Cruz Island to determine the prevalence of this disorder and identify those at risk. A 1-month ... -
Radiological Surveillance Screening in Asymptomatic Succinate Dehydrogenase Mutation Carriers
(The Endocrine Society, 2017-07-01) -
Excluding the pheochromocytoma
(Elsevier BV, 2017-12) -
Proteomic Analysis of the Human Anterior Pituitary Gland.
(Mary Ann Liebert, 2018-12-20)The pituitary function is regulated by a complex system involving the hypothalamus and biological networks within the pituitary. Although the hormones secreted from the pituitary have been well studied, comprehensive ... -
The current landscape of European registries for rare endocrine conditions
(BioScientifica, 2019-01)Objective To identify cross-border international registries for rare endocrine conditions that are led from Europe and to understand the extent of engagement with these registries within a network of reference centres ... -
Germline and mosaic mutations causing pituitary tumours: genetic and molecular aspects.
(Bioscientifica, 2019-02-01)While 95% of pituitary adenomas arise sporadically without a known inheritable predisposing mutation, in about 5% of the cases they can arise in a familial setting, either isolated (familial isolated pituitary adenoma or ... -
Novel methods in adrenal research: a metabolomics approach.
(Springer Link, 2019-02-06)Metabolic alterations have implications in a spectrum of tissue functions and disease. Aided by novel molecular biological and computational tools, our understanding of physiological and pathological processes underpinning ... -
An analysis of surveillance screening for SDHB-related disease in childhood and adolescence.
(2019-03-01)Objective Phaeochromocytomas (PCC) and paragangliomas (PGL) are rare in children. A large proportion of these are now understood to be due to underlying germline mutations. Here we focus on succinate dehydrogenase subunit ... -
Pseudoacromegaly
(Elsevier/Science Direct, 2018-11-15)© 2018 Elsevier Inc. Individuals with acromegaloid physical appearance or tall stature may be referred to endocrinologists to exclude growth hormone (GH) excess. While some of these subjects could be healthy individuals ... -
Nicotinamide Nucleotide Transhydrogenase as a Novel Treatment Target in Adrenocortical Carcinoma.
(2018-08-01)Adrenocortical carcinoma (ACC) is an aggressive malignancy with poor response to chemotherapy. In this study, we evaluated a potential new treatment target for ACC, focusing on the mitochondrial reduced form of NAD phosphate ... -
SGPL1 Deficiency: A Rare Cause of Primary Adrenal Insufficiency.
(Oxford University Press, 2018-12-03)Context Multiple autosomal recessive genes have been etiologically linked to Primary Adrenal Insufficiency (PAI). Recently, SGPL1 gene mutations were recognized as causes of steroid-resistant nephrotic syndrome type 14 ... -
Predicted Benign and Synonymous Variants in CYP11A1 Cause Primary Adrenal Insufficiency Through Missplicing.
(2019-01-01)Primary adrenal insufficiency (PAI) is a potentially life-threatening condition that can present with nonspecific features and can be difficult to diagnose. We undertook next generation sequencing in a cohort of children ... -
Molecular targets of atypical antipsychotics: From mechanism of action to clinical differences
(Elsevier/Science Direct, 2018-12)The introduction of atypical antipsychotics (AAPs) since the discovery of its prototypical drug clozapine has been a revolutionary pharmacological step for treating psychotic patients as these allow a significant recovery ...
