Centre for Endocrinology
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Research activity in the Centre for Endocrinology spans between clinically applied research in endocrinology to basic research in endocrine signalling pathways.
Recent Submissions
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Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: Part 1, general recommendations.
(2024-02-09)Tumours of the anterior part of the pituitary gland represent just 1% of all childhood (aged <15 years) intracranial neoplasms, yet they can confer high morbidity and little evidence and guidance is in place for their ... -
Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: Part 2, specific diseases.
(2024-02-09)Pituitary adenomas are rare in children and young people under the age of 19 (hereafter referred to as CYP) but they pose some different diagnostic and management challenges in this age group than in adults. These rare ... -
Tall stature and gigantism in adult patients with acromegaly.
(Oxford University Press, 2024-02-23)OBJECTIVES: Increased height in patients with acromegaly could be a manifestation of growth hormone (GH) excess before epiphysis closure. The aim of this study was to evaluate the relationship between the height of adult ... -
Ward monitoring 4.0: real-time metabolic insights from continuous glucose monitoring into perioperative organ dysfunction.
(2024-03-05)The now-routine clinical deployment of continuous glucose monitoring has demonstrated benefit in real-world settings. We make the case that continuous glucose monitoring can help re-examine, at scale, the role that (stress) ... -
Familial Glucocorticoid Deficiency: the changing landscape of an eponymous syndrome.
(Frontiers Media, 2023-12-21)Familial Glucocorticoid Deficiency encompasses a broad spectrum of monogenic recessive disorders that theoretically solely abrogate cortisol biosynthesis. In reality, delineating clear genotype-phenotype correlations in ... -
Primary aldosteronism: molecular medicine meets public health.
(Nature Research, 2023-08-23)Primary aldosteronism is the most common single cause of hypertension and is potentially curable when only one adrenal gland is the culprit. The importance of primary aldosteronism to public health derives from its high ... -
Laparoscopic adrenalectomy for phaeochromocytoma in the context of acute coronary syndrome
(Bioscientifica, 2023-11) -
Effects of the COVID-19 pandemic on the incidence of central precocious puberty; a narrative review.
(2024-02-26)Central precocious puberty (CPP) is the premature activation of the hypothalamus-pituitary-gonadal axis, resulting in the early development of secondary sexual characteristics. CPP classically occurs before the age of 8 ... -
Outcomes and experiences of adults with congenital hypogonadism can inform improvements in the management of delayed puberty.
(2024-01-29)Patients with congenital hypogonadism will encounter many health care professionals during their lives managing their health needs; from antenatal and infantile periods, through childhood and adolescence, into adult life ... -
Gonadotropins for pubertal induction in males with hypogonadotropic hypogonadism: systematic review and meta-analysis.
(2024-01-03)OBJECTIVE: Hypogonadotropic hypogonadism is characterized by inadequate secretion of pituitary gonadotropins, leading to absent, partial, or arrested puberty. In males, classical treatment with testosterone promotes ... -
Translating the potential of the urine steroid metabolome to stage NAFLD (TrUSt-NAFLD): study protocol for a multicentre, prospective validation study.
(2024-01-18)INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) affects approximately one in four individuals and its prevalence continues to rise. The advanced stages of NAFLD with significant liver fibrosis are associated with ... -
SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability.
(Nature Research, 2023-12-07)Innervation of the hypothalamic median eminence by Gonadotropin-Releasing Hormone (GnRH) neurons is vital to ensure puberty onset and successful reproduction. However, the molecular and cellular mechanisms underlying median ... -
MesoGraph: Automatic profiling of mesothelioma subtypes from histological images.
(2023-10-05)Mesothelioma is classified into three histological subtypes, epithelioid, sarcomatoid, and biphasic, according to the relative proportions of epithelioid and sarcomatoid tumor cells present. Current guidelines recommend ... -
THU079 Danio Rerio (Zebrafish): A New Model Of AIP Loss Of Function
(The Endocrine Society, 2023-10-05)