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Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer.
Ectopic (or tertiary) lymphoid structures (ELS) are organized aggregates of lymphocytes resembling secondary lymphoid organs and developing in chronically inflamed nonlymphoid tissues during persistent infections, graft ...
Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients
(Springer Nature, 2018-05-25)
Methotrexate (MTX) monotherapy is a common first treatment for rheumatoid arthritis (RA), but many patients do not respond adequately. In order to identify genetic predictors of response, we have combined data from two ...
Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages.
Microvesicles (MVs) are emerging as a novel means to enact cell-to-cell communication in inflammation. Here, we aimed to ascertain the ability of neutrophil-derived MVs to modulate target cell behaviour, the focus being ...
PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes.
(BMJ Publishing Group Ltd, 2019-02-26)
OBJECTIVE: We aimed to understand the role of the tyrosine phosphatase PTPN14-which in cancer cells modulates the Hippo pathway by retaining YAP in the cytosol-in fibroblast-like synoviocytes (FLS) from patients with ...
Validity of a two-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis
(Oxford University Press on behalf of the British Society for Rheumatology., 2018-04-25)
Objectives. Imaging of joint inflammation provides a standard against which to derive an updated DAS for RA. Our objectives were to develop and validate a DAS based on reweighting the DAS28 components to maximize ...