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    AuthorDalli, J (8)Fossati-Jimack, L (7)Izui, S (5)Pitzalis, C (5)Aubdool, AA (4)Botto, M (4)Perretti, M (4)Serhan, CN (4)Thiemermann, C (4)Cook, HT (3)... View MoreSubject
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    Humans (44)Mice (41)Male (19)Mice, Inbred C57BL (19)Signal Transduction (14)Female (13)Mice, Knockout (13)Macrophages (12)Cells, Cultured (11)... View MoreDate Issued2020 - 2022 (7)2010 - 2019 (57)2000 - 2009 (2)1991 - 1999 (6)
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    T cell metabolism. The protein LEM promotes CD8⁺ T cell immunity through effects on mitochondrial respiration. 

    Okoye, I; Wang, L; Pallmer, K; Richter, K; Ichimura, T; Haas, R; Crouse, J; Choi, O; Heathcote, D; Lovo, E;... (2015-04-16)
    Protective CD8(+) T cell-mediated immunity requires a massive expansion in cell number and the development of long-lived memory cells. Using forward genetics in mice, we identified an orphan protein named lymphocyte expansion ...
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    International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature. 

    Günther, T; Tulipano, G; Dournaud, P; Bousquet, C; Csaba, Z; Kreienkamp, H-J; Lupp, A; Korbonits, M; Castaño, JP; Wester, H-J;... (2018-10)
    Somatostatin, also known as somatotropin-release inhibitory factor, is a cyclopeptide that exerts potent inhibitory actions on hormone secretion and neuronal excitability. Its physiologic functions are mediated by five G ...
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    NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice. 

    Meimaridou, E; Goldsworthy, M; Chortis, V; Fragouli, E; Foster, PA; Arlt, W; Cox, R; Metherell, LA (2018-01)
    Nicotinamide nucleotide transhydrogenase, NNT, is a ubiquitous protein of the inner mitochondrial membrane with a key role in mitochondrial redox balance. NNT produces high concentrations of NADPH for detoxification of ...
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    SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. 

    Li, M; Li, Y; Weeks, O; Mijatovic, V; Teumer, A; Huffman, JE; Tromp, G; Fuchsberger, C; Gorski, M; Lyytikäinen, L-P;... (2017-03)
    Genome-wide association studies have identified >50 common variants associated with kidney function, but these variants do not fully explain the variation in eGFR. We performed a two-stage meta-analysis of associations ...
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    Annexin A1: Uncovering the Many Talents of an Old Protein. 

    Sheikh, MH; Solito, E (2018-03-31)
    Annexin A1 (ANXA1) has long been classed as an anti-inflammatory protein due to its control over leukocyte-mediated immune responses. However, it is now recognized that ANXA1 has widespread effects beyond the immune system ...
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    The Genetic Basis of Delayed Puberty. 

    Howard, SR; Dunkel, L (2018)
    The genetic control of puberty remains an important but mostly unanswered question. Late pubertal timing affects over 2% of adolescents and is associated with adverse health outcomes including short stature, reduced bone ...
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    Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation. 

    Bonacina, F; Coe, D; Wang, G; Longhi, MP; Baragetti, A; Moregola, A; Garlaschelli, K; Uboldi, P; Pellegatta, F; Grigore, L;... (2018-08-06)
    Cholesterol homeostasis has a pivotal function in regulating immune cells. Here we show that apolipoprotein E (apoE) deficiency leads to the accumulation of cholesterol in the cell membrane of dendritic cells (DC), resulting ...
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    The GTN patch: a simple and effective new approach to cardioprotection? 

    Yellon, DM; He, Z; Khambata, R; Ahluwalia, A; Davidson, SM (2018-04-17)
    There remains a significant un-met need to reduce the extent of myocardial injury caused by ischaemia and reperfusion injury in patients experiencing an ST-elevation MI. Although nitric oxide is central to many cardioprotective ...
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    Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure. 

    Baliga, RS; Preedy, MEJ; Dukinfield, MS; Chu, SM; Aubdool, AA; Bubb, KJ; Moyes, AJ; Tones, MA; Hobbs, AJ (2018-07-31)
    Heart failure (HF) is a shared manifestation of several cardiovascular pathologies, including hypertension and myocardial infarction, and a limited repertoire of treatment modalities entails that the associated morbidity ...
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    Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. 

    Rhys, HI; Dell'Accio, F; Pitzalis, C; Moore, A; Norling, LV; Perretti, M (2018-03)
    Microvesicles (MVs) are emerging as a novel means to enact cell-to-cell communication in inflammation. Here, we aimed to ascertain the ability of neutrophil-derived MVs to modulate target cell behaviour, the focus being ...
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