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Analysis of clonal expansions through the normal and premalignant human breast epithelium reveals the presence of luminal stem cells.
(Wiley, 2017-09-22)It is widely accepted that the cell of origin of breast cancer is the adult mammary epithelial stem cell, however demonstrating the presence and location of tissue stem cells in the human breast has proved difficult. ... -
ECIL-6 guidelines for the treatment of invasive candidiasis, aspergillosis and mucormycosis in leukemia and hematopoietic stem cell transplant patients.
(Haematologica, 2016-12-20)The European Conference on Infections in Leukemia (ECIL) provides recommendations for diagnostic strategies and prophylactic, pre-emptive or targeted therapy strategies for various types of infection in patients with ... -
BMI-1 extends proliferative potential of human bronchial epithelial cells while retaining their mucociliary differentiation capacity.
(American Physiological Society, 2016-12-15)Air-liquid interface (ALI) culture of primary airway epithelial cells enables mucociliary differentiation providing an in vitro model of the human airway, but their proliferative potential is limited. To extend proliferation, ... -
Longitudinal Single Cell Clonal Analyis Reveals Evolutionary Stasis and Predetermined Malignant Potential in Non-Dysplastic Barrett's Esophagus
(Wiley, 2016-10)Conference: 9th Joint Meeting of the British-Division of the International-Academy-of-Pathology and the Pathological-Society-of-Great-Britain-and-Ireland Location: Univ Nottingham, Sch Med, Acad Univ Mol Pathol Div Canc ... -
Expression of polymeric immunoglobulin receptor and stromal activity in pancreatic ductal adenocarcinoma.
(Elsevier, 2017-02-01)BACKGROUND/OBJECTIVES: Polymeric immunoglobulin receptor (pIgR) traffics Immunoglobulins (IgA and IgM) through epithelial cells in normal mucosae but neither are expressed in the normal pancreas. Recent work from our ...
