• Combining measures of immune infiltration shows additive effect on survival prediction in high-grade serous ovarian carcinoma 

  Montfort, A; Owen, S; Piskorz, AM; Supernat, A; Moore, L; Al-Khalidi, S; Bohm, S; Pharoah, P; McDermott, J; Balkwill, FR (2020-04-06)

• Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios. 

  Williams, MJ; Zapata, L; Werner, B; Barnes, CP; Sottoriva, A; Graham, TA (eLife Sciences Publications Ltd, 2020-03-30)

  The distribution of fitness effects (DFE) defines how new mutations spread through an evolving population. The ratio of non-synonymous to synonymous mutations (dN/dS) has become a popular method to detect selection in ...

• Measuring single cell divisions in human tissues from multi-region sequencing data. 

  Werner, B; Case, J; Williams, MJ; Chkhaidze, K; Temko, D; Fernández-Mateos, J; Cresswell, GD; Nichol, D; Cross, W; Spiteri, I (Nature Research (part of Springer Nature), 2020-02-25)

  Both normal tissue development and cancer growth are driven by a branching process of cell division and mutation accumulation that leads to intra-tissue genetic heterogeneity. However, quantifying somatic evolution in ...

• A new pragmatic design for dose escalation in phase 1 clinical trials using an adaptive continual reassessment method 

  North, B; Kocher, HM; Sasieni, P (2019-06-26)

• ROCK and Rac1 signalling in squamous cell carcinoma with loss of laminin 332 

  Caley, M; Martins, V; Moore, K; Lashari, M; Donaldson, M; Marshall, JF; O'Toole, EA (2016-05)

• Lipid Metabolism at the Nexus of Diet and Tumor Microenvironment 

  Peck, B; Schulze, A (Elsevier, 2019-11-01)

  Obesity is a leading contributing factor to cancer development worldwide. Epidemiological evidence suggests that diet affects cancer risk and also substantially alters therapeutic outcome. Therefore, studying the impact ...

• Exploiting evolutionary steering to induce collateral drug sensitivity in cancer 

  Acar, A; Nichol, D; Fernandez-Mateos, J; Cresswell, GD; Barozzi, I; Hong, SP; Trahearn, N; Spiteri, I; Stubbs, M; Burke, R (Springer Science and Business Media LLC, 2020-12)

• Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML 

  Basheer, F; Giotopoulos, G; Meduri, E; Yun, H; Mazan, M; Sasca, D; Gallipoli, P; Marando, L; Gozdecka, M; Asby, R (Rockefeller University Press, 2019-03-19)

  Epigenetic regulators, such as EZH2, are frequently mutated in cancer, and loss-of-function EZH2 mutations are common in myeloid malignancies. We have examined the importance of cellular context for Ezh2 loss during the ...

• Development of PancRISK, a urine biomarker-based risk score for stratified screening of pancreatic cancer patients. 

  Blyuss, O; Zaikin, A; Cherepanova, V; Munblit, D; Kiseleva, EM; Prytomanova, OM; Duffy, SW; Crnogorac-Jurcevic, T (Springer Nature, 2019-12-20)

  BACKGROUND: An accurate and simple risk prediction model that would facilitate earlier detection of pancreatic adenocarcinoma (PDAC) is not available at present. In this study, we compare different algorithms of risk ...

• Urine metallomics signature as an indicator of pancreatic cancer. 

  Schilling, K; Larner, F; Saad, A; Roberts, R; Kocher, HM; Blyuss, O; Halliday, AN; Crnogorac-Jurcevic, T (Royal Society of Chemistry, 2020-03-25)

  Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer. Its high mortality rate is attributed largely to the difficulty of early diagnosis. Analysis of urine is an excellent non-invasive approach ...

• Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring 

  Hijazi, M; Smith, R; Rajeeve, V; Bessant, C; Cutillas, PR (Nature Publishing, 2020-01-20)

  Understanding how oncogenic mutations rewire regulatory-protein networks is important for rationalizing the mechanisms of oncogenesis and for individualizing anticancer treatments. We report a chemical phosphoproteomics ...

• Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells. 

  Sundaresan, S; Meininger, CA; Kang, AJ; Photenhauer, AL; Hayes, MM; Sahoo, N; Grembecka, J; Cierpicki, T; Ding, L; Giordano, TJ (2017-12)

  BACKGROUND & AIMS: The multiple endocrine neoplasia, type 1 (MEN1) locus encodes the nuclear protein and tumor suppressor menin. MEN1 mutations frequently cause neuroendocrine tumors such as gastrinomas, characterized by ...

• Targeting Primitive Chronic Myeloid Leukemia Cells by Effective Inhibition of a New AHI-1BCR-ABL-JAK2 Complex 

  Chen, M; Gallipoli, P; DeGeer, D; Sloma, I; Forrest, DL; Chan, M; Lai, D; Jorgensen, H; Ringrose, A; Wang, HM (2013-03)

• A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression 

  Giotopoulos, G; van der Weyden, L; Osaki, H; Rust, AG; Gallipoli, P; Meduri, E; Horton, SJ; Chan, W-I; Foster, D; Prinjha, RK (2015-09-21)

• Cancer associated fibroblast FAK regulates malignant cell metabolism. 

  Demircioglu, F; Wang, J; Candido, J; Costa, ASH; Casado, P; de Luxan Delgado, B; Reynolds, LE; Gomez-Escudero, J; Newport, E; Rajeeve, V (2020-03-10)

  Emerging evidence suggests that cancer cell metabolism can be regulated by cancer-associated fibroblasts (CAFs), but the mechanisms are poorly defined. Here we show that CAFs regulate malignant cell metabolism through ...

• A novel use of random priming-based single-strand library preparation for whole genome sequencing of formalin-fixed paraffin-embedded tissue samples. 

  Saunderson, EA; Baker, A-M; Williams, M; Curtius, K; Jones, JL; Graham, TA; Ficz, G (2020-03)

  The desire to analyse limited amounts of biological material, historic samples and rare cell populations has collectively driven the need for efficient methods for whole genome sequencing (WGS) of limited amounts of poor ...

• IGHV sequencing reveals acquired N-glycosylation sites as a clonal and stable event during follicular lymphoma evolution. 

  Odabashian, M; Carlotti, E; Araf, S; Okosun, J; Spada, F; Gribben, JG; Forconi, F; Stevenson, FK; Calaminici, M; Krysov, S (2020-03-12)

  Follicular lymphoma B cells undergo continuous somatic hypermutation (SHM) of their immunoglobulin variable region genes, generating a heterogeneous tumor population. SHM introduces DNA sequences encoding N-glycosylation ...

• Pancreatic Cancer UK Grand Challenge: Developments and challenges for effective CAR T cell therapy for pancreatic ductal adenocarcinoma. 

  Cutmore, LC; Brown, NF; Raj, D; Chauduri, S; Wang, P; Maher, J; Wang, Y; Lemoine, NR; Marshall, JF (2020-02-15)

  BACKGROUND: Death from pancreatic ductal adenocarcinoma (PDAC) is rising across the world and PDAC is predicted to be the second most common cause of cancer death in the USA by 2030. Development of effective biotherapies ...

• Casein kinase 1 family proteins promote Slimb-dependent Expanded degradation 

  Fulford, AD; Holder, MV; Frith, D; Snijders, AP; Tapon, N; Ribeiro, PS (2019-09-30)

• How many samples are needed to infer truly clonal mutations from heterogenous tumours? 

  Opasic, L; Zhou, D; Werner, B; Dingli, D; Traulsen, A (2019-04-29)

  BACKGROUND: Modern cancer treatment strategies aim to target tumour specific genetic (or epigenetic) alterations. Treatment response improves if these alterations are clonal, i.e. present in all cancer cells within tumours. ...

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