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The 2019 Mathematical Oncology Roadmap.
(IOP Publishing, 2019-04-16)Whether the nom de guerre is Mathematical Oncology, Computational or Systems Biology, Theoretical Biology, Evolutionary Oncology, Bioinformatics, or simply Basic Science, there is no denying that mathematics continues to ... -
Fibroblast growth factor family as a potential target in the treatment of hepatocellular carcinoma.
(Dove Medical Press, 2014-05-29)Hepatocellular cancer (HCC) is currently the third leading cause of cancer death worldwide. The prognosis of patients diagnosed with late-stage disease is dismal due to high resistance to conventional systemic therapies. ... -
Inter- and intra-tumoural heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma.
(Wiley Online, 2018-12-21)Cancer-associated fibroblasts (CAF) are orchestrators of the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Stromal heterogeneity may explain differential pathophysiological roles of the stroma (pro- versus ... -
The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome
(Springer Nature, 2019-03-28)Purpose: There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in ... -
RESULTS OF INTENSIVE ALGORITHM-BASED SCREENING IN THE UK FAMILIAL OVARIAN CANCER SCREENING STUDY (UK FOCSS PHASE 2)
(ESGO and IGCS., 2013-10)Objectives To establish the performance of intensive screening for familial ovarian cancer using the risk of ovarian cancer algorithm (ROCA) and transvaginal sonogrpahy (TVS). Methods Between 14/06/2007 and 29/03/2012, ... -
Crypt fusion as a homeostatic mechanism in the human colon.
(BMJ, 2019-03-14)OBJECTIVE: The crypt population in the human intestine is dynamic: crypts can divide to produce two new daughter crypts through a process termed crypt fission, but whether this is balanced by a second process to remove ... -
PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer
(Elsevier/Science Direct, 2018-02-27)Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine. Here, we show that PHLDA1 downregulation is critical to ... -
A Transcriptomic Comparison of Two Bambara Groundnut Landraces under Dehydration Stress
(MDPI, 2017-04-18)The ability to grow crops under low-water conditions is a significant advantage in relation to global food security. Bambara groundnut is an underutilised crop grown by subsistence farmers in Africa and is known to survive ... -
miR-132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity.
(2019-04)Determining the mechanisms that distinguish protective immunity from pathological chronic inflammation remains a fundamental challenge. miR-132 has been shown to play largely immunoregulatory roles in immunity; however, ... -
CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma
(American Association for Cancer Research, 2016-06-20)Other than an association with HPV infection, little is known about the genetic alterations determining the development of penile cancer. Although penile cancer is rare in the developed world, it presents a significant ... -
Efficacy of systemic temozolomide-activated phage-targeted gene therapy in human glioblastoma.
(Wiley-VCH Verlag, 2019-02-26)Glioblastoma multiforme (GBM) is the most lethal primary intracranial malignant neoplasm in adults and most resistant to treatment. Integration of gene therapy and chemotherapy, chemovirotherapy, has the potential to improve ... -
Ovarian cancer in adolescents and young adults.
(Wiley, 2018-10-23)The diagnosis of ovarian cancer in adolescents and young adults is always challenging. Many issues exist, and most important of these may be access to care with an appropriate provider. A range of histologies occur in the ... -
Targeting CDH17 in Cancer: When Blocking the Ligand Beats Blocking the Receptor?
(2018-01-15)Cadherin-17 (CDH17) has been implicated as protumorigenic for many years, but mechanisms have been unclear. A Spanish team has generated antibodies to an RGD motif in CDH17 that inhibits integrin α2β1 binding to CDH17 and ... -
The Novel Oncolytic Adenoviral Mutant Ad5-3Δ-A20T Retargeted to αvβ6 Integrins Efficiently Eliminates Pancreatic Cancer Cells.
(2018-02)Metastatic pancreatic ductal adenocarcinomas (PDAC) are incurable due to the rapid development of resistance to all current therapeutics. Oncolytic adenoviral mutants have emerged as a promising new strategy that negates ... -
The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer
(Impact journals, 2015-10-07)Patterns of glycosylation are important in cancer, but the molecular mechanisms that drive changes are often poorly understood. The androgen receptor drives prostate cancer (PCa) development and progression to lethal ... -
The PI3K regulatory subunit gene PIK3R1 is under direct control of androgens and repressed in prostate cancer cells.
(Impact Journals, 2015-09-14)Androgen receptor (AR) signalling and the PI3K pathway mediate survival signals in prostate cancer, and have been shown to regulate each other by reciprocal negative feedback, such that inhibition of one activates the ... -
Effect of Comorbidity on Prostate Cancer-Specific Mortality: A Prospective Observational Study.
(2017-11-01)Purpose To determine the effect of comorbidity on prostate cancer (PCa)-specific mortality across treatment types. Patients and Methods These are the results of a population-based observational study in Sweden from 1998 ...
