• Endothelial Jagged1 promotes solid tumor growth through both pro-angiogenic and angiocrine functions 

  Pedrosa, A-R; Trindade, A; Carvalho, C; Graca, J; Carvalho, S; Peleteiro, MC; Adams, RH; Duarte, A (Impact Journals, LLC, 2015-06-08)

  Angiogenesis is an essential process required for tumor growth and progression. The Notch signaling pathway has been identified as a key regulator of the neo-angiogenic process. Jagged-1 (Jag1) is a Notch ligand required ...

• Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis 

  Stojic, L; Lun, ATL; Mangeri, J; Mascalchi, P; Quarantotti, V; Barr, AR; Bakal, C; Marioni, JC; Gergely, F; Odom, DT (Oxford University Press, 2018-07-06)

• Spotlight On Early Career Researchers: an interview with Lovorka Stojic 

  Lee, J-E; Stojic, L (Springer Nature, 2019-06-14)

• The Role of Csmd1 during Mammary Gland Development. 

  Burgess, SJ; Gibbs, H; Toomes, C; Coletta, PL; Bell, SM (MDPI, 2021-01-26)

  The Cub Sushi Multiple Domains-1 (CSMD1) protein is a tumour suppressor which has been shown to play a role in regulating human mammary duct development in vitro. CSMD1 knockdown in vitro demonstrated increased cell ...

• A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division 

  Stojic, L; Lun, A; Mascalchi, P; Ernst, C; Redmond, A; Mangei, J; Barr, A; Bousgouni, V; Bakal, C; Marioni, J (2019-07-19)

  bioRxiv preprint version. Now published in Nature Communications doi: 10.1038/s41467-020-14978-7.

• Hallmarks of cancer-the new testament. 

  Senga, SS; Grose, RP (Royal Society Publishing, 2021-01-20)

  Diagnosis and treatment of disease demand a sound understanding of the underlying mechanisms, determining any Achilles' heel that can be targeted in effective therapies. Throughout history, this endeavour to decipher the ...

• Unconventional role of RAC1 in MET-driven anchorage-independent tumor growth. 

  Hervieu, A; Kermorgant, S (2020-08-18)

  We reported that RAC1 is a master regulator of cell migration and anchorage-independent growth, downstream of the oncogenic Receptor Tyrosine Kinase (RTK) MET. RAC1 growth-promoting role is guanosine triphosphatase (GTPase)- ...

• Outcomes of patients with hematologic malignancies and COVID-19: a systematic review and meta-analysis of 3377 patients 

  Vijenthira, A; Gong, IY; Fox, TA; Booth, S; Cook, G; Fattizzo, B; Martin-Moro, F; Razanamahery, J; Riches, JC; Zwicker, J (2020-12-17)

• In Chronic Lymphocytic Leukemia Delta CT7544-7545 Mutant NOTCH1 Maintains Transcription Factor Activity with Longer Lasting Effects Due to Slower Degradation 

  Edelmann, J; Klymenko, T; Lu, C; Vilventhraraja, E; Estenfelder, S; Tausch, E; Beers, SA; Stilgenbauer, S; Cragg, MS; Ivanov, A (2016-12-02)

• Multiplatform Profiling Characterizes Functional Networks in Genomically Stable and Instable Chronic Lymphocytic Leukemia 

  Bloehdorn, J; Braun, A; Jebaraj, BMC; Taylor-Weiner, A; Robrecht, S; Krzykalla, J; Holzmann, K; Johnston, H; Klymenko, T; Eichhorst, B (2020-11-05)

• Anti-CD20 Monoclonal Antibodies Hijack the B-Cell Receptor Signaling Cascade Thereby Activating the NOTCH1 Signaling Pathway 

  Edelmann, J; Britton, DJ; Vilventhraraja, E; Dokal, A; Holzmann, K; Cragg, MC; Braun, A; Cutillas, P; Gribben, JG (2018-11-29)

• NUCLEAR LAMINA REGULATES SOMATIC HYPERMUTATION AND PROGRESSION OF B CELL MALIGNANCIES 

  Klymenko, T; Bloehdorn, J; Bahlo, J; Robrecht, S; Wang, J; Fischer, K; Akylzhanova, G; Edelmann, J; Estenfelder, S; Strefford, J (2017-06-26)

• Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches. 

  Byrne, KM; Monsefi, N; Dawson, JC; Degasperi, A; Bukowski-Wills, J-C; Volinsky, N; Dobrzyński, M; Birtwistle, MR; Tsyganov, MA; Kiyatkin, A (2016-01-27)

  Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modeling, mass spectrometry-based quantitation of network ...

• ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy. 

  Handley, MT; Reddy, K; Wills, J; Rosser, E; Kamath, A; Halachev, M; Falkous, G; Williams, D; Cox, P; Meynert, A (2019-03)

  Typical Martsolf syndrome is characterized by congenital cataracts, postnatal microcephaly, developmental delay, hypotonia, short stature and biallelic hypomorphic mutations in either RAB3GAP1 or RAB3GAP2. Genetic analysis ...

• The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype 

  Hari, P; Millar, FR; Tarrats, N; Birch, J; Quintanilla, A; Rink, CJ; Fernandez-Duran, I; Muir, M; Finch, AJ; Brunton, VG (2019-06)

• Long Noncoding RNAs at the Crossroads of Cell Cycle and Genome Integrity 

  Guiducci, G; Stojic, L (Elsevier, 2021-03-01)

• Rituximab and obinutuzumab differentially hijack the B-cell receptor and NOTCH1 signaling pathways. 

  Edelmann, J; Dokal, AD; Vilventhraraja, E; Holzmann, K; Britton, D; Klymenko, T; Döhner, H; Cragg, M; Braun, A; Cutillas, P (2021-01-21)

• Regulation and function of the palmitoyl-acyltransferase ZDHHC5. 

  Woodley, KT; Collins, MO (2021-01-08)

  Protein palmitoylation (S-acylation) has emerged as an important player in a range of cellular processes, and as a result, the palmitoyl-acyltransferase (PAT) enzymes which mediate this modification have entered into the ...

• The role of CAF derived exosomal microRNAs in the tumour microenvironment of melanoma. 

  Shelton, M; Anene, CA; Nsengimana, J; Roberts, W; Newton-Bishop, J; Boyne, JR (2020-10-22)

  Exosomes play a crucial role in the crosstalk between cancer associated fibroblasts (CAFs) and cancer cells, contributing to carcinogenesis and the tumour microenvironment. Recent studies have revealed that CAFs, normal ...

• Heartburn Sensation in Non-Erosive Reflux Disease: Pattern of Superficial Sensory Nerves Expressing TRPV1 and Epithelial Cells Expressing ASIC3 Receptors. 

  Ustaoglu, A; Sawada, A; Lee, C; Lei, W-Y; Chen, C-L; Hackett, R; Sifrim, D; Peiris, M; Woodland, P (2021-03-03)

  The underlying causes of heartburn, characteristic symptom of gastro-esophageal reflux disease(GERD), remain incompletely understood. Superficial afferent innervation of the esophageal mucosa in nonerosive reflux disease(NERD) ...

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