Centre for Cancer & Inflammation
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Disentangling the roles of aneuploidy, chromosomal instability and tumour heterogeneity in developing resistance to cancer therapies.
(2023-09-18)Aneuploidy is defined as the cellular state of having a number of chromosomes that deviates from a multiple of the normal haploid chromosome number of a given organism. Aneuploidy can be present in a static state: Down ... -
Cell cycle responses to Topoisomerase II inhibition: Molecular mechanisms and clinical implications.
(2023-12-04)DNA Topoisomerase IIA (Topo IIA) is an enzyme that alters the topological state of DNA and is essential for the separation of replicated sister chromatids and the integrity of cell division. Topo IIA dysfunction activates ... -
Seminoma and dysgerminoma: evidence for alignment of clinical trials and de-escalation of systemic chemotherapy.
(2023)Malignant germ cell tumours are a group of rare cancers whose incidence peaks in late adolescence and early adulthood. Dysgerminomas of the ovary and seminomas of the testis are analogous diseases, but seminomas have a ... -
Augmented reality in liver surgery.
(2023-04)INTRODUCTION: During an operation, augmented reality (AR) enables surgeons to enrich their vision of the operating field by means of digital imagery, particularly as regards tumors and anatomical structures. While in some ... -
Réalité augmentée en chirurgie hépatique
(Elsevier, 2023-04) -
Introducing a structured daily multidisciplinary board round to safely enhance surgical ward patient flow in the bed shortage era: a quality improvement research report.
(2023-03)Hospital bed shortage is a worldwide concern. Their unavailability has caused elective surgery cancellations at our hospital peaking in spring 2016 at over 50%. This is often due to difficult patient step-down from intensive ... -
Proof-of-principle validation of a novel intraluminal optical sensor for dynamic monitoring of intestinal anastomosis: An in vivo animal model case study
(2022-10-30)Intestinal resections are commonly performed to treat different colorectal conditions, including colorectal cancer. A successful primary anastomosis is the desired optimal outcome after intestinal resection. Maintaining ...