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A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia.

Foxler, DE; Bridge, KS; Foster, JG; Grevitt, P; Curry, S; Shah, KM; Davidson, KM; Nagano, A; Gadaleta, E; Rhys, HI;... (2018-08)

The adaptive cellular response to low oxygen tensions is mediated by the hypoxia-inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF-α and HIF-β subunits. Prolonged HIF expression is ...

Spatial Sampling in Barrett's Oesophagus Shows Clonal Evolution of Oesophageal Adenocarcinoma from Metaplastic Non-Goblet Columnar Epithelium

Jansen, M; McDonald, SA; Lavery, D; Wright, NA; Martinez, P; Graham, TA; Gay, LJ (2015-09)

Characterization of LGR5 stem cells in colorectal adenomas and carcinomas

Baker, A-M; Graham, TA; Elia, G; Wright, NA; Rodriguez-Justo, M (2015-03-02)

Evolution of oesophageal adenocarcinoma from metaplastic columnar epithelium without goblet cells in Barrett's oesophagus

Lavery, DL; Martinez, P; Gay, LJ; Cereser, B; Novelli, MR; Rodriguez-Justo, M; Meijer, SL; Graham, TA; McDonald, SAC; Wright, NA;... (2016-06)

PIK3CA mutations are common in lobular carcinoma in situ, but are not a biomarker of progression

Shah, V; Nowinski, S; Levi, D; Shinomiya, I; Chaabouni, NKE; Gillett, C; Grigoriadis, A; Graham, TA; Roylance, R; Simpson, MA;... (2017-01-17)

Between-region genetic divergence reflects the mode and tempo of tumor evolution

Sun, R; Hu, Z; Sottoriva, A; Graham, TA; Harpak, A; Ma, Z; Fischer, JM; Shibata, D; Curtis, C (2017-07)

New paradigms in clonal evolution: punctuated equilibrium in cancer

Cross, WCH; Graham, TA; Wright, NA (2016-10)

From Colitis to Cancer: An Evolutionary Trajectory That Merges Maths and Biology

Al Bakir, I; Curtius, K; Graham, TA (2018-10-16)

Forty-Year Analysis of Colonoscopic Surveillance Program for Neoplasia in Ulcerative Colitis: An Updated Overview

Choi, C-HR; Rutter, MD; Askari, A; Lee, GH; Warusavitarne, J; Moorghen, M; Thomas-Gibson, S; Saunders, BP; Graham, TA; Hart, AL (2015-07)

Clonal evolution of colorectal cancer in IBD

Choi, C-HR; Al Bakir, I; Hart, AL; Graham, TA (2017-04)

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