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    AuthorGanuza, M (5)Heeschen, C (4)Kang, G (4)McKinney-Freeman, S (4)Balic, A (3)Bi, W (3)Chabot, A (3)Hidalgo, M (3)Sainz, B (3)Trabulo, SM (3)... View MoreSubjectAnimals (21)
    Mice (21)
    Humans (14)Female (8)Signal Transduction (6)Hematopoiesis (5)Hematopoietic Stem Cells (5)Xenograft Model Antitumor Assays (5)Carcinoma, Pancreatic Ductal (4)Cell Line, Tumor (4)... View MoreDate Issued2020 - 2021 (2)2010 - 2019 (18)2007 - 2009 (1)
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    TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. 

    Ottaviani, S; Stebbing, J; Frampton, AE; Zagorac, S; Krell, J; de Giorgio, A; Trabulo, SM; Nguyen, VTM; Magnani, L; Feng, H;... (2018-05-10)
    TGF-β/Activin induces epithelial-to-mesenchymal transition and stemness in pancreatic ductal adenocarcinoma (PDAC). However, the microRNAs (miRNAs) regulated during this response have remained yet undetermined. Here, we ...
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    Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate. 

    Moniz, LS; Surinova, S; Ghazaly, E; Velasco, LG; Haider, S; Rodríguez-Prados, JC; Berenjeno, IM; Chelala, C; Vanhaesebroeck, B (2017-01-06)
    To identify novel effectors and processes regulated by PI3K pathway activation, we performed an unbiased phosphoproteomic screen comparing two common events of PI3K deregulation in cancer: oncogenic Pik3ca mutation ...
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    AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation. 

    Naeem, AS; Zhu, Y; Di, WL; Marmiroli, S; O'Shaughnessy, RFL (2015-12)
    Nuclear degradation is a key stage in keratinocyte terminal differentiation and the formation of the cornified envelope that comprises the majority of epidermal barrier function. Parakeratosis, the retention of nuclear ...
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    DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells. 

    Ribeiro, PS; Kuranaga, E; Tenev, T; Leulier, F; Miura, M; Meier, P (2007-12-31)
    In addition to their well-known function in apoptosis, caspases are also important in several nonapoptotic processes. How caspase activity is restrained and shut down under such nonapoptotic conditions remains unknown. ...
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    Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts. 

    Hermann, PC; Trabulo, SM; Sainz, B; Balic, A; Garcia, E; Hahn, SA; Vandana, M; Sahoo, SK; Tunici, P; Bakker, A;... (2013)
    PURPOSE: In spite of intense research efforts, pancreatic ductal adenocarcinoma remains one of the most deadly malignancies in the world. We and others have previously identified a subpopulation of pancreatic cancer stem ...
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    Exosomes derived from embryonal and alveolar rhabdomyosarcoma carry differential miRNA cargo and promote invasion of recipient fibroblasts. 

    Ghayad, SE; Rammal, G; Ghamloush, F; Basma, H; Nasr, R; Diab-Assaf, M; Chelala, C; Saab, R (2016-11-17)
    Rhabdomyosarcoma (RMS) is an aggressive childhood soft tissue tumor, which exists in oncoprotein PAX-FOXO1 fusion positive and fusion negative subtypes, with the fusion-positive RMS being characterized by a more aggressive ...
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    Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling. 

    Balic, A; Sørensen, MD; Trabulo, SM; Sainz, B; Cioffi, M; Vieira, CR; Miranda-Lorenzo, I; Hidalgo, M; Kleeff, J; Erkan, M;... (2014-07)
    Pancreatic ductal adenocarcinoma is one of the deadliest carcinomas and is characterized by highly tumorigenic and metastatic cancer stem cells (CSC). CSCs evade available therapies, which preferentially target highly ...
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    Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions. 

    Guitart, AV; Panagopoulou, TI; Villacreces, A; Vukovic, M; Sepulveda, C; Allen, L; Carter, RN; van de Lagemaat, LN; Morgan, M; Giles, P;... (2017-03-06)
    Strict regulation of stem cell metabolism is essential for tissue functions and tumor suppression. In this study, we investigated the role of fumarate hydratase (Fh1), a key component of the mitochondrial tricarboxylic ...
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    Insights Into the Pathophysiology of Esophageal Adenocarcinoma. 

    Quante, M; Graham, TA; Jansen, M (2018-01)
    Although researchers have identified genetic alterations that contribute to development of esophageal adenocarcinoma, we know little about features of patients or environmental factors that mediate progression of chronic ...
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    Humanization of bone and bone marrow in an orthotopic site reveals new potential therapeutic targets in osteosarcoma. 

    Wagner, F; Holzapfel, BM; McGovern, JA; Shafiee, A; Baldwin, JG; Martine, LC; Lahr, CA; Wunner, FM; Friis, T; Bas, O;... (2018-07)
    BACKGROUND: Existing preclinical murine models often fail to predict effects of anti-cancer drugs. In order to minimize interspecies-differences between murine hosts and human bone tumors of in vivo xenograft platforms, ...
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