• Assessing BRCA1 activity in DNA damage repair using human induced pluripotent stem cells as an approach to assist classification of BRCA1 variants of uncertain significance 

  Ozgencil, M; Barwell, J; Tischkowitz, M; Izatt, L; Kesterton, I; Simpson, M; Sharpe, P; de Sepulveda, P; Voisset, E; Solomon, E (2021)

• First-in-human dose-escalation and expansion study (MITOPE) to evaluate mitochondrial PRX3 inhibition by RSO-021 in patients with mesothelioma and other advanced solid tumors 

  Dulloo, S; Fennell, DA; Szlosarek, PW; Thistlethwaite, F; Lord, S; Rahman, NM; Greystoke, A; Cunniff, B; Dzialo, J; Poile, C (2022)

• Chromosome Instability through the Ages: Parallels between Speciation and Somatic (Cancer) Evolution 

  MacDonald, C; McClelland, SE (2021)

• Diversity in chromosome numbers promotes resistance to chemotherapeutics 

  Shaikh, N; McClelland, SE (2021)

• Cells on lockdown: long-term consequences of CDK4/6 inhibition 

  Barr, AR; McClelland, SE (2022)

• Molecular pro fi ling of ctDNA in pancreatic cancer: Opportunities and challenges for clinical application 

  Sivapalan, L; Kocher, HM; Ross-Adams, H; Chelala, C (2021)

• New Bioconjugated Technetium and Rhenium Folates Synthesized by Transmetallation Reaction with Zinc Derivatives 

  Borras, J; Foster, J; Kashani, R; Melendez-Alafort, L; Sosabowski, J; Suades, J; Barnadas-Rodriguez, R (2021)

• The Transcriptomic Landscape of Prostate Cancer Development and Progression: An Integrative Analysis 

  Marzec, J; Ross-Adams, H; Pirro, S; Wang, J; Zhu, Y; Mao, X; Gadaleta, E; Ahmad, AS; North, BV; Kammerer-Jacquet, S-F (2021)

• Longitudinal profiling of circulating tumour DNA for tracking tumour dynamics in pancreatic cancer 

  Sivapalan, L; Thorn, G; Gadaleta, E; Kocher, H; Ross-Adams, H; Chelala, C (2021)

  The utility of circulating tumour DNA (ctDNA) for longitudinal tumour monitoring in pancreatic ductal adenocarcinoma (PDAC) has not been explored beyond mutations in the KRAS proto-oncogene. Here, we follow 3 patients with ...

• Small vessel vasculitis and dry gangrene secondary to combined CTLA-4 and PD-1 blockade in malignant mesothelioma 

  Kefas, J; Harwood, C; Lewis, MJ; Szlosarek, P (2022)

• Quality of life from cytoreductive surgery in advanced ovarian cancer: Investigating the association between disease burden and surgical complexity in the international, prospective, SOCQER-2 cohort study 

  Sundar, S; Cummins, C; Kumar, S; Long, J; Arora, V; Balega, J; Broadhead, T; Duncan, T; Edmondson, R; Fotopoulou, C (2022)

• A cohort study of 30 day mortality after NON-EMERGENCY surgery in a COVID-19 cold site. 

  Kasivisvanathan, V; Lindsay, J; Rakshani-Moghadam, S; Elhamshary, A; Kapriniotis, K; Kazantzis, G; Syed, B; Hines, J; Bex, A; Ho, DH (2020-12)

  BACKGROUND: Two million non-emergency surgeries are being cancelled globally every week due to the COVID-19 pandemic, which will have a major impact on patients and healthcare systems. METHODS: During the peak of the ...

• Corrigendum to "A standard operating technique to facilitate early return of urinary continence after robotic prostatectomy outcomes of a consensus meeting of experts with experience of over 30,000 cases" [Eur Urol Suppl 2017;16;e2301-2]. 

  Sridhar, AN; Sooriakumaran, P; Rajan, P; Shaw, G; Briggs, T; Kelly, J; Dasgupta, P; Desai, M; Wiklund, P; Haese, A (2020-12)

• A novel vaccinia virus enhances anti-tumor efficacy and promotes a long-term anti-tumor response in a murine model of colorectal cancer 

  Wang, N; Wang, J; Zhang, Z; Cao, H; Yan, W; Chu, Y; Dunmall, LSC; Wang, Y (Elsevier (Cell Press), 2021-03-26)

  Colorectal cancer (CRC) is one of the leading causes of mortality and morbidity in the world, and there remains an urgent need to develop long-lasting therapies to treat CRC and prevent recurrence in patients. Oncolytic ...

• Safety and utility of image-guided research biopsies in relapsed high-grade serous ovarian carcinoma-experience of the BriTROC consortium (vol 116, pg 1294, 2017) 

  Goranova, T; Ennis, D; Piskorz, AM; Macintyre, G; Lewsley, LA; Stobo, J; Wilson, C; Kay, D; Glasspool, RM; Lockley, M (2019)

• Chloroxine overrides DNA damage tolerance to restore platinum sensitivity in high-grade serous ovarian cancer 

  Silva, VL; Saxena, J; Nicolini, F; Hoare, JI; Metcalf, S; Martin, SA; Lockley, M (Springer Nature, 2021-04-14)

  High-grade serous cancer (HGSC) accounts for ~67% of all ovarian cancer deaths. Although initially sensitive to platinum chemotherapy, resistance is inevitable and there is an unmet clinical need for novel therapies that ...

• Nivolumab versus placebo in patients with relapsed malignant mesothelioma (CONFIRM): a multicentre, double-blind, randomised, phase 3 trial. 

  Fennell, DA; Ewings, S; Ottensmeier, C; Califano, R; Hanna, GG; Hill, K; Danson, S; Steele, N; Nye, M; Johnson, L (Elsevier, 2021-10-14)

  BACKGROUND: No phase 3 trial has yet shown improved survival for patients with pleural or peritoneal malignant mesothelioma who have progressed following platinum-based chemotherapy. The aim of this study was to assess the ...

• Phase 1, pharmacogenomic, dose-expansion study of pegargiminase plus pemetrexed and cisplatin in patients with ASS1-deficient non-squamous non-small cell lung cancer 

  Szlosarek, PW; Wimalasingham, AG; Phillips, MM; Hall, PE; Chan, PY; Conibear, J; Lim, L; Rashid, S; Steele, J; Wells, P (Wiley, 2021-08-12)

  Introduction We evaluated the arginine-depleting enzyme pegargiminase (ADI-PEG20; ADI) with pemetrexed (Pem) and cisplatin (Cis) (ADIPemCis) in ASS1-deficient non-squamous non-small cell lung cancer (NSCLC) via a phase 1 ...

• Non-Invasive Biomarkers for Earlier Detection of Pancreatic Cancer-A Comprehensive Review 

  Brezgyte, G; Shah, V; Jach, D; Crnogorac-Jurcevic, T (MDPI, 2021-05-31)

• Phase 1b study of pegylated arginine deiminase (ADI-PEG 20) plus Pembrolizumab in advanced solid cancers 

  Chang, K-Y; Chiang, N-J; Wu, S-Y; Yen, C-J; Chen, S-H; Yeh, Y-M; Li, C-F; Feng, X; Wu, K; Johnston, A (Taylor & Francis, 2021-01-01)

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