Centre for Tumour Biology
Browse by
Recent Submissions
-
Measures of genetic diversification in somatic tissues at bulk and single-cell resolution.
(eLife Sciences Publications, 2024-01-24)Intra-tissue genetic heterogeneity is universal to both healthy and cancerous tissues. It emerges from the stochastic accumulation of somatic mutations throughout development and homeostasis. By combining population genetics ... -
A somatic genetic clock for clonal species.
(Nature Research, 2024-06-10)Age and longevity are key parameters for demography and life-history evolution of organisms. In clonal species, a widespread life history among animals, plants, macroalgae and fungi, the sexually produced offspring (genet) ... -
Chemotherapy Assessment in Advanced Multicellular 3D Models of Pancreatic Cancer: Unravelling the Importance of Spatiotemporal Mimicry of the Tumor Microenvironment.
(2024-02-07)Pancreatic ductal adenocarcinoma (PDAC) is a challenge for global health with very low survival rate and high therapeutic resistance. Hence, advanced preclinical models for treatment screening are of paramount importance. ... -
Drice restrains Diap2-mediated inflammatory signalling and intestinal inflammation
(Springer Nature, 2021-07-14) -
Abstract P6-10-05: Mutations in the RNA Splicing Factor SF3B1 drive endocrine therapy resistance and confer a targetable replication stress response defect through PARP inhibition
(American Association for Cancer Research (AACR), 2023-03-01) -
Mutation divergence over space in tumour expansion.
(2023-11)Mutation accumulation in tumour evolution is one major cause of intra-tumour heterogeneity (ITH), which often leads to drug resistance during treatment. Previous studies with multi-region sequencing have shown that mutation ... -
Genetic and immune landscape evolution in MMR-deficient colorectal cancer.
(2023-11-15)Mismatch repair-deficient (MMRd) colorectal cancers (CRCs) have high mutation burdens, which make these tumours immunogenic and many respond to immune checkpoint inhibitors. The MMRd hypermutator phenotype may also promote ...