• Inter- and intra-tumoural heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma. 

  Neuzillet, C; Tijeras-Raballand, A; Ragulan, C; Cros, J; Patil, Y; Martinet, M; Erkan, M; Kleeff, J; Wilson, J; Apte, M (Wiley Online, 2018-12-21)

  Cancer-associated fibroblasts (CAF) are orchestrators of the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Stromal heterogeneity may explain differential pathophysiological roles of the stroma (pro- versus ...

• Crypt fusion as a homeostatic mechanism in the human colon. 

  Baker, A-M; Gabbutt, C; Williams, MJ; Cereser, B; Jawad, N; Rodriguez-Justo, M; Jansen, M; Barnes, CP; Simons, BD; McDonald, SA (BMJ, 2019-03-14)

  OBJECTIVE: The crypt population in the human intestine is dynamic: crypts can divide to produce two new daughter crypts through a process termed crypt fission, but whether this is balanced by a second process to remove ...

• PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer 

  Fearon, AE; Carter, EP; Clayton, NS; Wilkes, EH; Baker, A-M; Kapitonova, E; Bakhouche, BA; Tanner, Y; Wang, J; Gadaleta, E (Elsevier/Science Direct, 2018-02-27)

  Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine. Here, we show that PHLDA1 downregulation is critical to ...

• Targeting CDH17 in Cancer: When Blocking the Ligand Beats Blocking the Receptor? 

  Marshall, JF (2018-01-15)

  Cadherin-17 (CDH17) has been implicated as protumorigenic for many years, but mechanisms have been unclear. A Spanish team has generated antibodies to an RGD motif in CDH17 that inhibits integrin α2β1 binding to CDH17 and ...

• Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium-specific FAK-kinase dead mice 

  Alexopoulou, AN; Lees, DM; Bodrug, N; Lechertier, T; Fernandez, I; D'Amico, G; Dukinfield, M; Batista, S; Tavora, B; Serrels, B (2017-07)

• A Multiscale Model Evaluates Screening for Neoplasia in Barrett's Esophagus 

  Curtius, K; Hazelton, WD; Jeon, J; Luebeck, EG (2015-05)

• Identification of a key role of widespread epigenetic drift in Barrett's esophagus and esophageal adenocarcinoma 

  Luebeck, EG; Curtius, K; Hazelton, WD; Maden, S; Yu, M; Thota, PN; Patil, DT; Chak, A; Willis, JE; Grady, WM (2017-10-16)

• Harnessing the immune system in glioblastoma. 

  Brown, NF; Carter, TJ; Ottaviani, D; Mulholland, P (2018-11)

  Glioblastoma is the most common primary malignant brain tumour. Survival is poor and improved treatment options are urgently needed. Although immunotherapies have emerged as effective treatments for a number of cancers, ...

• Emerging Roles of Fibroblast Growth Factor 10 in Cancer. 

  Clayton, NS; Grose, RP (2018)

  Whilst cross-talk between stroma and epithelium is critical for tissue development and homeostasis, aberrant paracrine stimulation can result in neoplastic transformation. Chronic stimulation of epithelial cells with ...

• An international perspective on hospitalized patients with viral community-acquired pneumonia 

  Radovanovic, D; Sotgiu, G; Jankovic, M; Mahesh, PA; Jorge Marcos, P; Abdalla, MI; Di Pasquale, MF; Gramegna, A; Terraneo, S; Blasi, F (2019-02)

• Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international, observational cohort study 

  Aliberti, S; Reyes, LF; Faverio, P; Sotgiu, G; Dore, S; Rodriguez, AH; Soni, NJ; Restrepo, MI; Aruj, PK; Attorri, S (2016-12)

• Burden and Risk Factors for Pseudomonas aeruginosa Community-acquired Pneumonia: a Multinational Point Prevalence Study of Hospitalised Patients 

  Restrepo, MI; Babu, BL; Reyes, LF; Chalmers, JD; Soni, NJ; Sibila, O; Faverio, P; Cilloniz, C; Rodriguez-Cintron, W; Aliberti, S

• Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations. 

  Su, T; Grady, JP; Afshar, S; McDonald, SA; Taylor, RW; Turnbull, DM; Greaves, LC (2018-12)

  Inherited mitochondrial DNA (mtDNA) mutations cause mitochondrial disease, but mtDNA mutations also occur somatically and accumulate during ageing. Studies have shown that the mutation load of some inherited mtDNA mutations ...

• Implications of Epigenetic Drift in Colorectal Neoplasia 

  Luebeck, GE; Hazelton, WD; Curtius, K; Maden, SK; Yu, M; Carter, KT; Burke, W; Lampe, PD; Li, CI; Ulrich, CM (2019-02-01)

• MULTI-REGION EXOME SEQUENCING REVEALS THE CLONAL EVOLUTION OF COLITIS-ASSOCIATED COLORECTAL CANCER 

  Baker, A-M; Davis, CHRCH; Al-Bakir, I; Martinez, P; Temko, D; Cross, W; Williams, M; Biswas, S; McDonald, SA; Wright, NA (2017-04)

• Quantification of subclonal selection in cancer from bulk sequencing data 

  Williams, MJ; Werner, B; Heide, T; Curtis, C; Barnes, CP; Sottoriva, A; Graham, TA (2018-06)

• Targeting of Aberrant alpha v beta 6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells 

  Whilding, LM; Parente-Pereira, AC; Zabinski, T; Davies, DM; Petrovic, RMG; Kao, YV; Saxena, SA; Romain, A; Costa-Guerra, JA; Violette, S (2017-01-04)

• From Colitis to Cancer: An Evolutionary Trajectory That Merges Maths and Biology 

  Al Bakir, I; Curtius, K; Graham, TA (2018-10-16)

• In vivo bioassay to test the pathogenicity of missense human AIP variants. 

  Aflorei, ED; Klapholz, B; Chen, C; Radian, S; Dragu, AN; Moderau, N; Prodromou, C; Ribeiro, PS; Stanewsky, R; Korbonits, M (2018-08)

  BACKGROUND: Heterozygous germline loss-of-function mutations in the aryl hydrocarbon receptor-interacting protein gene (AIP) predispose to childhood-onset pituitary tumours. The pathogenicity of missense variants may pose ...

• The evolutionary landscape of colorectal tumorigenesis 

  Cross, W; Kovac, M; Mustonen, V; Temko, D; Davis, H; Baker, A-M; Biswas, S; Arnold, R; Chegwidden, L; Gatenbee, C (2018-10)

  The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant) remain largely undetermined. Using multi-region genome and exome sequencing of 24 benign and malignant colorectal tumours, ...

View more