Centre for Tumour Biology

 

Recent Submissions

  • The evolutionary landscape of colorectal tumorigenesis. 

    Cross, W; Kovac, M; Mustonen, V; Temko, D; Davis, H; Baker, A-M; Biswas, S; Arnold, R; Chegwidden, L; Gatenbee, C;... (Springer Nature, 2018-08-31)
    The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant) remain largely undetermined. Using multi-region genome and exome sequencing of 24 benign and malignant colorectal tumours, ...

  • Switchable CAR-T cells mediate remission in metastatic pancreatic ductal adenocarcinoma. 

    Raj, D; Yang, M-H; Rodgers, D; Hampton, EN; Begum, J; Mustafa, A; Lorizio, D; Garces, I; Propper, D; Kench, JG;... (BMJ Publishing Group, 2018-08-18)
    OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is a disease of unmet medical need. While immunotherapy with chimeric antigen receptor T (CAR-T) cells has shown much promise in haematological malignancies, their efficacy ...

  • Evolutionary history of human colitis-associated colorectal cancer. 

    Baker, A-M; Cross, W; Curtius, K; Al Bakir, I; Choi, C-HR; Davis, HL; Temko, D; Biswas, S; Martinez, P; Williams, MJ;... (BMJ, 2018-07-10)
    OBJECTIVE: IBD confers an increased lifetime risk of developing colorectal cancer (CRC), and colitis-associated CRC (CA-CRC) is molecularly distinct from sporadic CRC (S-CRC). Here we have dissected the evolutionary history ...

  • A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia. 

    Foxler, DE; Bridge, KS; Foster, JG; Grevitt, P; Curry, S; Shah, KM; Davidson, KM; Nagano, A; Gadaleta, E; Rhys, HI;... (2018-06-21)
    The adaptive cellular response to low oxygen tensions is mediated by the hypoxia-inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF-α and HIF-β subunits. Prolonged HIF expression is ...

  • A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus. 

    Curtius, K; Wong, C-J; Hazelton, WD; Kaz, AM; Chak, A; Willis, JE; Grady, WM; Luebeck, EG (Public Library of Science, 2016-05-11)
    Biomarkers that drift differentially with age between normal and premalignant tissues, such as Barrett's esophagus (BE), have the potential to improve the assessment of a patient's cancer risk by providing quantitative ...
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