• Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium-specific FAK-kinase dead mice 

  Alexopoulou, AN; Lees, DM; Bodrug, N; Lechertier, T; Fernandez, I; D'Amico, G; Dukinfield, M; Batista, S; Tavora, B; Serrels, B (2017-07)

• A Multiscale Model Evaluates Screening for Neoplasia in Barrett's Esophagus 

  Curtius, K; Hazelton, WD; Jeon, J; Luebeck, EG (2015-05)

• Identification of a key role of widespread epigenetic drift in Barrett's esophagus and esophageal adenocarcinoma 

  Luebeck, EG; Curtius, K; Hazelton, WD; Maden, S; Yu, M; Thota, PN; Patil, DT; Chak, A; Willis, JE; Grady, WM (2017-10-16)

• Harnessing the immune system in glioblastoma. 

  Brown, NF; Carter, TJ; Ottaviani, D; Mulholland, P (2018-11)

  Glioblastoma is the most common primary malignant brain tumour. Survival is poor and improved treatment options are urgently needed. Although immunotherapies have emerged as effective treatments for a number of cancers, ...

• Emerging Roles of Fibroblast Growth Factor 10 in Cancer. 

  Clayton, NS; Grose, RP (2018)

  Whilst cross-talk between stroma and epithelium is critical for tissue development and homeostasis, aberrant paracrine stimulation can result in neoplastic transformation. Chronic stimulation of epithelial cells with ...

• An international perspective on hospitalized patients with viral community-acquired pneumonia. 

  Radovanovic, D; Sotgiu, G; Jankovic, M; Mahesh, PA; Marcos, PJ; Abdalla, MI; Di Pasquale, MF; Gramegna, A; Terraneo, S; Blasi, F (2018-11-04)

  BACKGROUND: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, ...

• Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international, observational cohort study 

  Aliberti, S; Reyes, LF; Faverio, P; Sotgiu, G; Dore, S; Rodriguez, AH; Soni, NJ; Restrepo, MI; Aruj, PK; Attorri, S (2016-12)

• Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations. 

  Su, T; Grady, JP; Afshar, S; McDonald, SA; Taylor, RW; Turnbull, DM; Greaves, LC (2018-12)

  Inherited mitochondrial DNA (mtDNA) mutations cause mitochondrial disease, but mtDNA mutations also occur somatically and accumulate during ageing. Studies have shown that the mutation load of some inherited mtDNA mutations ...

• Implications of Epigenetic Drift in Colorectal Neoplasia. 

  Luebeck, GE; Hazelton, WD; Curtius, K; Maden, SK; Yu, M; Carter, KT; Burke, W; Lampe, PD; Li, CI; Ulrich, CM (2019-02-01)

  : Many normal tissues undergo age-related drift in DNA methylation, providing a quantitative measure of tissue age. Here, we identify and validate 781 CpG islands (CGI) that undergo significant methylomic drift in 232 ...

• MULTI-REGION EXOME SEQUENCING REVEALS THE CLONAL EVOLUTION OF COLITIS-ASSOCIATED COLORECTAL CANCER 

  Baker, A-M; Davis, CHRCH; Al-Bakir, I; Martinez, P; Temko, D; Cross, W; Williams, M; Biswas, S; McDonald, SA; Wright, NA (2017-04)

• Quantification of subclonal selection in cancer from bulk sequencing data 

  Williams, MJ; Werner, B; Heide, T; Curtis, C; Barnes, CP; Sottoriva, A; Graham, TA (2018-06)

• Targeting of Aberrant alpha v beta 6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells 

  Whilding, LM; Parente-Pereira, AC; Zabinski, T; Davies, DM; Petrovic, RMG; Kao, YV; Saxena, SA; Romain, A; Costa-Guerra, JA; Violette, S (2017-01-04)

• From Colitis to Cancer: An Evolutionary Trajectory That Merges Maths and Biology 

  Al Bakir, I; Curtius, K; Graham, TA (2018-10-16)

• In vivo bioassay to test the pathogenicity of missense human AIP variants. 

  Aflorei, ED; Klapholz, B; Chen, C; Radian, S; Dragu, AN; Moderau, N; Prodromou, C; Ribeiro, PS; Stanewsky, R; Korbonits, M (2018-08)

  BACKGROUND: Heterozygous germline loss-of-function mutations in the aryl hydrocarbon receptor-interacting protein gene (AIP) predispose to childhood-onset pituitary tumours. The pathogenicity of missense variants may pose ...

• The evolutionary landscape of colorectal tumorigenesis 

  Cross, W; Kovac, M; Mustonen, V; Temko, D; Davis, H; Baker, A-M; Biswas, S; Arnold, R; Chegwidden, L; Gatenbee, C (2018-10)

  The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant) remain largely undetermined. Using multi-region genome and exome sequencing of 24 benign and malignant colorectal tumours, ...

• Switchable CAR-T cells mediate remission in metastatic pancreatic ductal adenocarcinoma. 

  Raj, D; Yang, M-H; Rodgers, D; Hampton, EN; Begum, J; Mustafa, A; Lorizio, D; Garces, I; Propper, D; Kench, JG (2018-08-18)

  OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is a disease of unmet medical need. While immunotherapy with chimeric antigen receptor T (CAR-T) cells has shown much promise in haematological malignancies, their efficacy ...

• Evolutionary history of human colitis-associated colorectal cancer. 

  Baker, A-M; Cross, W; Curtius, K; Al Bakir, I; Choi, C-HR; Davis, HL; Temko, D; Biswas, S; Martinez, P; Williams, MJ (2018-07-10)

  OBJECTIVE: IBD confers an increased lifetime risk of developing colorectal cancer (CRC), and colitis-associated CRC (CA-CRC) is molecularly distinct from sporadic CRC (S-CRC). Here we have dissected the evolutionary history ...

• A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia. 

  Foxler, DE; Bridge, KS; Foster, JG; Grevitt, P; Curry, S; Shah, KM; Davidson, KM; Nagano, A; Gadaleta, E; Rhys, HI (2018-08)

  The adaptive cellular response to low oxygen tensions is mediated by the hypoxia-inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF-α and HIF-β subunits. Prolonged HIF expression is ...

• A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus 

  Curtius, K; Wong, C-J; Hazelton, WD; Kaz, AM; Chak, A; Willis, JE; Grady, WM; Luebeck, EG (2016-05)

• Catch my drift? Making sense of genomic intra-tumour heterogeneity 

  Sottoriva, A; Barnes, CP; Graham, TA (2017-04)

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