Recent Submissions

  • A Multiscale Model Evaluates Screening for Neoplasia in Barrett's Esophagus. 

    Curtius, K; Hazelton, WD; Jeon, J; Luebeck, EG (Public Library of Science, 2015-05-22)
    Barrett's esophagus (BE) patients are routinely screened for high grade dysplasia (HGD) and esophageal adenocarcinoma (EAC) through endoscopic screening, during which multiple esophageal tissue samples are removed for ...
  • Identification of a key role of widespread epigenetic drift in Barrett's esophagus and esophageal adenocarcinoma. 

    Luebeck, EG; Curtius, K; Hazelton, WD; Maden, S; Yu, M; Thota, PN; Patil, DT; Chak, A; Willis, JE; Grady, WM (2017-10-16)
    BACKGROUND: Recent studies have identified age-related changes in DNA methylation patterns in normal and cancer tissues in a process that is called epigenetic drift. However, the evolving patterns, functional consequences, ...
  • Harnessing the immune system in glioblastoma. 

    Brown, NF; Carter, TJ; Ottaviani, D; Mulholland, P (Springer Nature, 2018-11-05)
    Glioblastoma is the most common primary malignant brain tumour. Survival is poor and improved treatment options are urgently needed. Although immunotherapies have emerged as effective treatments for a number of cancers, ...
  • Emerging Roles of Fibroblast Growth Factor 10 in Cancer. 

    Clayton, NS; Grose, RP (2018-10-24)
    Whilst cross-talk between stroma and epithelium is critical for tissue development and homeostasis, aberrant paracrine stimulation can result in neoplastic transformation. Chronic stimulation of epithelial cells with ...
  • Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations 

    Su, T; Grady, J; Afshar, S; MCDONALD, SAC; Taylor, R; Douglass, T; Greaves, L (John Wiley & Sons Ltd., 2018-08-26)
    Inherited mitochondrial DNA (mtDNA) mutations cause mitochondrial disease, but mtDNA mutations also occur somatically and accumulate during ageing. Studies have shown that the mutation load of some inherited mtDNA mutations ...
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