RSS 1.0Centre for Tumour Biology
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Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations
(John Wiley & Sons Ltd., 2018-08-26)Inherited mitochondrial DNA (mtDNA) mutations cause mitochondrial disease, but mtDNA mutations also occur somatically and accumulate during ageing. Studies have shown that the mutation load of some inherited mtDNA mutations ... -
Implications of epigenetic drift in colorectal neoplasia.
(American Association for Cancer Research, 2018-10-05)Many normal tissues undergo age-related drift in DNA methylation, providing a quantitative measure of tissue age. Here we identify and validate 781 CpG-islands (CGI) that undergo significant methylomic drift in 232 normal ... -
MULTI-REGION EXOME SEQUENCING REVEALS THE CLONAL EVOLUTION OF COLITIS-ASSOCIATED COLORECTAL CANCER
(Elsevier Inc., 2017-04)Conference: Digestive Disease Week (DDW) Location: Chicago, IL Date: MAY 06-09, 2017 -
Quantification of subclonal selection in cancer from bulk sequencing data
(Springer Nature, 2018-05-28)Subclonal architectures are prevalent across cancer types. However, the temporal evolutionary dynamics that produce tumour subclones remain unknown. Here we measure clone dynamics in human cancers using computational ... -
Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells.
(2017-01-04)Expression of the αvβ6 integrin is upregulated in several solid tumors. In contrast, physiologic expression of this epithelial-specific integrin is restricted to development and epithelial re-modeling. Here, we describe, ...
