Centre for Tumour Biology
Browse by
Recent Submissions
-
Single-cell sequencing reveals the heterogeneity and intratumoral crosstalk in human endometrial cancer
(2022-05-13)Background: Endometrial cancer (EC) is one of the most common gynecologic malignancies with increasing morbidity. Cell–cell and cell-matrix interactions within the tumour microenvironment (TME) exert a powerful influence ... -
Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer.
(2017-06-01)Background: Patients often ask oncologists how long a cancer has been present before causing symptoms or spreading to other organs. The evolutionary trajectory of cancers can be defined using phylogenetic approaches but ... -
Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance.
(2022-01-10)Mechanisms of drug-tolerance remain poorly understood and have been linked to genomic but also to non-genomic processes. 5-fluorouracil (5-FU), the most widely used chemotherapy in oncology is associated with resistance. ... -
Natural killer cells in pancreatic cancer stroma
(2021-06-28) -
FGF signalling facilitates cervical cancer progression
(2022-01-03) -
Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer.
(Springer Nature, 2017-04-20)Drugs that inhibit estrogen receptor-α (ER) activity have been highly successful in treating and reducing breast cancer progression in ER-positive disease. However, resistance to these therapies presents a major clinical ...