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Noninvasive Diagnosis of Pancreatic Cancer Through Detection of Volatile Organic Compounds in Urine.

Arasaradnam, RP; Wicaksono, A; O'Brien, H; Kocher, HM; Covington, JA; Crnogorac-Jurcevic, T (2018-02)

Durable graft-versus-leukaemia effects without donor lymphocyte infusions - results of a phase II study of sequential T-replete allogeneic transplantation for high-risk acute myeloid leukaemia and myelodysplasia.

Davies, JK; Hassan, S; Sarker, S-J; Besley, C; Oakervee, H; Smith, M; Taussig, D; Gribben, JG; Cavenagh, JD (2018-02)

Allogeneic haematopoietic stem-cell transplantation remains the only curative treatment for relapsed/refractory acute myeloid leukaemia (AML) and high-risk myelodysplasia but has previously been limited to patients who ...

Does type 2 diabetes mellitus promote intervertebral disc degeneration?

Fabiane, SM; Ward, KJ; Iatridis, JC; Williams, FMK (2016-09)

PURPOSE: LDD is an important cause of low back pain. Many people believe there is an adverse influence of type 2 diabetes (T2D) on lumbar intervertebral disc degeneration (LDD). We examined a population sample for ...

Over expression of HIF1α is associated with inactivation of both LimD1 and VHL in renal cell carcinoma: Clinical importance.

Sur, S; Maurya, AK; Roy, A; Sharp, TV; Pal, DK; Panda, CK (2017-12)

It is evident that the association of LimD1 and VHL could regulate stabilization of HIF1α protein. In this study, the expression of LimD1, VHL and HIF1α was analyzed in primary renal cell carcinoma (RCC) samples to understand ...

The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia.

Di Tullio, A; Rouault-Pierre, K; Abarrategi, A; Mian, S; Grey, W; Gribben, J; Stewart, A; Blackwood, E; Bonnet, D (2017-11-22)

Cytarabine (AraC) represents the most effective single agent treatment for AML. Nevertheless, overriding AraC resistance in AML remains an unmet medical need. Here we show that the CHK1 inhibitor (CHK1i) GDC-0575 enhances ...

Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency.

Hurst, CD; Alder, O; Platt, FM; Droop, A; Stead, LF; Burns, JE; Burghel, GJ; Jain, S; Klimczak, LJ; Lindsay, H;... (2017-11-13)

Bladder cancer incurs a higher lifetime treatment cost than other cancers due to frequent recurrence of non-invasive disease. Improved prognostic biomarkers and localized therapy are needed for this large patient group. ...

Robotic and Advanced Laparoscopic Surgical Training in European Gynecological Oncology Trainees.

Gan, C; Bossart, M; Piek, J; Halaska, M; Haidopoulos, D; Zapardiel, I; Grabowski, JP; Kesic, V; Kimmig, R; Cibula, D;... (2017-02)

INTRODUCTION: Advanced minimal access surgical training is an important component of training in gynecological oncology (GO). Europe-wide data on this topic are lacking. We present data on availability and trainee experience ...

Expression of polycomb protein BMI-1 maintains the plasticity of basal bronchial epithelial cells.

Torr, E; Heath, M; Mee, M; Shaw, D; Sharp, TV; Sayers, I (2016-08)

The airway epithelium is altered in respiratory disease and is thought to contribute to disease etiology. A caveat to disease research is that the technique of isolation of bronchial epithelial cells from patients is ...