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BMI-1 extends proliferative potential of human bronchial epithelial cells while retaining their mucociliary differentiation capacity.

Munye, MM; Shoemark, A; Hirst, RA; Delhove, JM; Sharp, TV; McKay, TR; O'Callaghan, C; Baines, DL; Howe, SJ; Hart, SL (2017-02-01)

Air-liquid interface (ALI) culture of primary airway epithelial cells enables mucociliary differentiation providing an in vitro model of the human airway, but their proliferative potential is limited. To extend proliferation, ...

The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia.

Di Tullio, A; Rouault-Pierre, K; Abarrategi, A; Mian, S; Grey, W; Gribben, J; Stewart, A; Blackwood, E; Bonnet, D (2017-11-22)

Cytarabine (AraC) represents the most effective single agent treatment for AML. Nevertheless, overriding AraC resistance in AML remains an unmet medical need. Here we show that the CHK1 inhibitor (CHK1i) GDC-0575 enhances ...

TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression.

Ottaviani, S; Stebbing, J; Frampton, AE; Zagorac, S; Krell, J; de Giorgio, A; Trabulo, SM; Nguyen, VTM; Magnani, L; Feng, H;... (2018-05-10)

TGF-β/Activin induces epithelial-to-mesenchymal transition and stemness in pancreatic ductal adenocarcinoma (PDAC). However, the microRNAs (miRNAs) regulated during this response have remained yet undetermined. Here, we ...

Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids.

Linch, M; Sanz-Garcia, M; Rosse, C; Riou, P; Peel, N; Madsen, CD; Sahai, E; Downward, J; Khwaja, A; Dillon, C;... (2014-02)

Protein kinase C iota (PKCι), a serine/threonine kinase required for cell polarity, proliferation and migration, is commonly up- or downregulated in cancer. PKCι is a human oncogene but whether this is related to its role ...

SEARCHBreast: An online resource designed to increase the efficiency of using materials derived from breast cancer studies in animals.

Speirs, V; Morrisey, B; Holen, I; Blyth, K; Carter, P; Chelala, C; Jones, L (2016-09)

Exosomes derived from embryonal and alveolar rhabdomyosarcoma carry differential miRNA cargo and promote invasion of recipient fibroblasts.

Ghayad, SE; Rammal, G; Ghamloush, F; Basma, H; Nasr, R; Diab-Assaf, M; Chelala, C; Saab, R (2016-11-17)

Rhabdomyosarcoma (RMS) is an aggressive childhood soft tissue tumor, which exists in oncoprotein PAX-FOXO1 fusion positive and fusion negative subtypes, with the fusion-positive RMS being characterized by a more aggressive ...

Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate.

Moniz, LS; Surinova, S; Ghazaly, E; Velasco, LG; Haider, S; Rodríguez-Prados, JC; Berenjeno, IM; Chelala, C; Vanhaesebroeck, B (2017-01-06)

To identify novel effectors and processes regulated by PI3K pathway activation, we performed an unbiased phosphoproteomic screen comparing two common events of PI3K deregulation in cancer: oncogenic Pik3ca mutation ...