Centre for Haemato-Oncology
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Recent Submissions
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Liquid biopsy in lymphoma: Is it primed for clinical translation?
(2021-08)The simultaneous growth in our understanding of lymphoma biology and the burgeoning therapeutic options has come with a renewed drive for precision-based approaches and how best to incorporate them into contemporary and ... -
Systematic Evaluation of Somatic Cis-Regulatory Mutations in Follicular Lymphoma
(American Society of Hematology, 2020-11-05) -
Abstract IA38: Defining lymphoma reservoirs: Clues from the genomics
(American Association for Cancer Research (AACR), 2020-11-01) -
Genetic heterogeneity in follicular lymphoma
(AME Publishing Company, 2021-06-30)The genetic underpinnings of follicular lymphoma (FL) are now better understood through sequencing efforts of the last decade. Epigenetic deregulation, particularly through mutations in chromatin-modifying enzymes, is ... -
Molecular Pathogenesis of Follicular Lymphoma and Its Relevance to Clinical Practice
(Elsevier, 2021-08-30) -
Impact of Double Expression of MYC and BCL-2 on Outcomes in Primary CNS Lymphoma: A UK Multicentre Analysis
(American Society of Hematology, 2022-11-15) -
Revising the Treatment Pathways in Lymphoma: New Standards of Care-How Do We Choose?
(2022-04)Diffuse large B-cell lymphoma and follicular lymphoma are the most commonly encountered non-Hodgkin lymphomas in clinical practice. Both are biologically heterogeneous, with management strategies that are becoming increasingly ... -
Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation.
(2016-01-28)Antigenic stimulation via the B-cell receptor (BCR) is a major driver of the proliferation and survival of chronic lymphocytic leukemia (CLL) cells. However, the precise mechanisms by which BCR stimulation leads to ... -
Lectins from opportunistic bacteria interact with acquired variable-region glycans of surface immunoglobulin in follicular lymphoma.
(2015-05-21)B-cell antigen receptor (BCR) expression is a key feature of most B-cell lymphomas, but the mechanisms of BCR signal induction and the involvement of autoantigen recognition remain unclear. In follicular lymphoma (FL) B ... -
Minimal residual disease is a significant predictor of treatment failure in non T-lineage adult acute lymphoblastic leukaemia: final results of the international trial UKALL XII/ECOG2993.
(2010-01)The predictive value of molecular minimal residual disease (MRD) monitoring using polymerase chain reaction amplification of clone-specific immunoglobulin or T-cell Receptor rearrangements was analysed in 161 patients with ...