• Overcoming resistance to arginine deprivation therapy using GC7 in pleural mesothelioma. 

  Carpentier, J; Freitas, M; Morales, V; Bianchi, K; Bomalaski, J; Szlosarek, P; Martin, SA (Elsevier, 2025-01-17)

  Pleural mesothelioma is a highly chemotherapy-resistant cancer. Approximately 50% of mesotheliomas do not express argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme in arginine biosynthesis, making arginine ...

• Epigenome-wide differential methylation and differential variability as predictors of high-grade cervical intraepithelial neoplasia (cin2+). 

  Bukowski, A; Hoyo, C; Graff, M; Vielot, NA; Kosorok, MR; Brewster, WR; Maguire, RL; Murphy, SK; Nedjai, B; Ladoukakis, E (Oxford University Press, 2024-08-08)

  CpG site methylation patterns have potential to improve differentiation of high-grade screening-detected cervical abnormalities. We assessed CpG differential methylation (DM) and differential variability (DV) in high-grade ...

• The current state of DNA methylation biomarkers in self-collected liquid biopsies for the early detection of cervical cancer: a literature review. 

  Sumiec, EG; Yim, ZY; Mohy-Eldin, H; Nedjai, B (BMC, 2024-12-18)

  Cervical cancer (CC) is a preventable disease and treatable cancer. Most of the new cases and deaths from CC occur in Low- and Middle-Income Countries (LMICs) due to cultural and systematic barriers leading to low CC ...

• Exploring the Link Between Obligate Anaerobe-Related Dysbiosis and Prostate Cancer Development: A Pilot Study. 

  Ladoukakis, E; Oliver, T; Wilks, M; Lane, EF; Chinegwundoh, F; Shaw, G; Nedjai, B (MDPI, 2024-12-29)

  BACKGROUND/OBJECTIVES: Several independent studies have associated prostate cancer (PCa) with specific groups of bacteria, most of them reporting the presence of anaerobic or microaerophilic species such as Cutibacterium ...

• First-in-human phase I clinical trial of RSO-021, a first-in class covalent inhibitor of mitochondrial peroxiredoxin 3 (PRX3), in patients with malignant pleural effusion due to mesothelioma and other advanced solid tumors (MITOPE). 

  Fennell, DA; Dulloo, S; Lord, S; Thistlethwaite, F; Blyth, KG; Szlosarek, PW; Maskell, N; Popat, S; Aujayeb, A; Aktas, BY (American Society of Clinical Oncology (ASCO), 2024-06-01)

• ADI-PEG20 and GC7 as a novel anti-metabolite strategy for the treatment of malignant pleural mesothelioma 

  Carpentier, J; Szlosarek, PW; Martin, SA (2023)

• Abstract C027: RSO-021, a first-in-class covalent inhibitor of mitochondrial PRX3: From bench to bedside 

  Fennell, DA; Dulloo, S; Szlosarek, P; Thistlethwaite, F; Lord, S; Rahman, NM; Cunniff, B; Dzialo, J; Poile, C; Panchal, R (American Association for Cancer Research (AACR), 2023-12-01)

• 135 (PB123): MITOPE: Phase 2 evaluation of RSO-021, a novel mitochondrial PRX3 inhibitor, as a monotherapy and in combination with paclitaxel in patients with malignant pleural effusion due to mesothelioma or other advanced solid tumors 

  Naumov, G; Dulloo, S; Fennell, D; Lord, S; Thistlethwaite, F; Maskell, N; Popat, S; Blyth, K; Szlosarek, P; Aujayeb, A (Elsevier, 2024-10)

• Paraoxonase gene polymorphisms and haplotype analysis in a stroke population 

  Pasdar, A; Ross-Adams, H; Cumming, A; Cheung, J; Whalley, L; St Clair, D; MacLeod, MJ (BMC, 2006-03-21)

• Mining human prostate cancer datasets: The “camcAPP” shiny app 

  Dunning, MJ; Vowler, SL; Lalonde, E; Ross-Adams, H; Mills, IG; Lynch, AG; Lamb, AD

• Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer. 

  Gadaleta, E; Fourgoux, P; Pirró, S; Thorn, GJ; Nelan, R; Ironside, A; Rajeeve, V; Cutillas, PR; Lobley, AE; Wang, J (Springer Nature, 2020-08-21)

  Widespread mammographic screening programs and improved self-monitoring allow for breast cancer to be detected earlier than ever before. Breast-conserving surgery is a successful treatment for select women. However, up to ...

• Early functional mismatch between breast cancer cells and their tumour microenvironment suppresses long term growth 

  Rosell, AP; Maiques, O; Martin, JAJ; Chakravarty, P; Ombrato, L; Sanz-Moreno, V; Malanchi, I (Elsevier, 2022-07-06)

• LAP1 supports nuclear adaptability during constrained melanoma cell migration and invasion 

  Jung-Garcia, Y; Maiques, O; Monger, J; Rodriguez-Hernandez, I; Fanshawe, B; Domart, M-C; Renshaw, MJ; Marti, RM; Matias-Guiu, X; Collinson, LM (Springer Nature, 2023-01-09)

• AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration 

  Crosas-Molist, E; Graziani, V; Maiques, O; Pandya, P; Monger, J; Samain, R; George, SL; Malik, S; Salise, J; Morales, V (Springer Nature, 2023-05-22)

• A systematic pan-cancer study on deep learning-based prediction of multi-omic biomarkers from routine pathology images. 

  Arslan, S; Schmidt, J; Bass, C; Mehrotra, D; Geraldes, A; Singhal, S; Hense, J; Li, X; Raharja-Liu, P; Maiques, O (Springer Nature, 2024-03-15)

  BACKGROUND: The objective of this comprehensive pan-cancer study is to evaluate the potential of deep learning (DL) for molecular profiling of multi-omic biomarkers directly from hematoxylin and eosin (H&E)-stained whole ...

• CD73 controls Myosin II-driven invasion, metastasis, and immunosuppression in amoeboid pancreatic cancer cells. 

  Samain, R; Maiques, O; Monger, J; Lam, H; Candido, J; George, S; Ferrari, N; KohIhammer, L; Lunetto, S; Varela, A (American Association for the Advancement of Science (AAAS), 2023-10-18)

  Pancreatic ductal adenocarcinoma (PDAC) has a very poor prognosis because of its high propensity to metastasize and its immunosuppressive microenvironment. Using a panel of pancreatic cancer cell lines, three-dimensional ...

• Pan-cancer drivers of metastasis. 

  Lusby, R; Demirdizen, E; Inayatullah, M; Kundu, P; Maiques, O; Zhang, Z; Terp, MG; Sanz-Moreno, V; Tiwari, VK (BMC, 2025-01-02)

  Metastasis remains a leading cause of cancer-related mortality, irrespective of the primary tumour origin. However, the core gene regulatory program governing distinct stages of metastasis across cancers remains poorly ...

• Bench-to-Bedside Studies of Arginine Deprivation in Cancer 

  Field, GC; Pavlyk, I; Szlosarek, PW (MDPI, 2023-02-24)

• 305 (PB293): Preclinical development of PLGA-encapsulated Disulfiram for treatment of malignant mesothelioma 

  Lakshmanan, Y; Butcher, K; Azar, K; Ireson, C; Jain, S; Wang, Y; Szlosarek, P; Kannappan, V; Weiguang, W (Elsevier, 2024-10)

• Trends in incidence, prevalence, and survival of breast cancer in the United Kingdom from 2000 to 2021. 

  Barclay, NL; Burn, E; Delmestri, A; Duarte-Salles, T; Golozar, A; Man, WY; Tan, EH; Tietzova, I; OPTIMA Consortium; Prieto-Alhambra, D (Springer Nature, 2024-08-17)

  Breast cancer is the most frequently diagnosed cancer in females globally. However, we know relatively little about trends in males. This study describes United Kingdom (UK) secular trends in breast cancer from 2000 to ...

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