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Durable graft-versus-leukaemia effects without donor lymphocyte infusions - results of a phase II study of sequential T-replete allogeneic transplantation for high-risk acute myeloid leukaemia and myelodysplasia.

Davies, JK; Hassan, S; Sarker, S-J; Besley, C; Oakervee, H; Smith, M; Taussig, D; Gribben, JG; Cavenagh, JD (2018-02)

Allogeneic haematopoietic stem-cell transplantation remains the only curative treatment for relapsed/refractory acute myeloid leukaemia (AML) and high-risk myelodysplasia but has previously been limited to patients who ...

Opportunistic bilateral salpingectomy (OBS) for the prevention of ovarian cancer should be offered in the context of a clinical trial: FOR: There is lack of clarity on a number of key issues.

Manchanda, R; Menon, U (2016-02)

Opportunistic salpingectomy for prevention of ovarian cancer.

Manchanda, R (2017-05)

Over expression of HIF1α is associated with inactivation of both LimD1 and VHL in renal cell carcinoma: Clinical importance.

Sur, S; Maurya, AK; Roy, A; Sharp, TV; Pal, DK; Panda, CK (2017-12)

It is evident that the association of LimD1 and VHL could regulate stabilization of HIF1α protein. In this study, the expression of LimD1, VHL and HIF1α was analyzed in primary renal cell carcinoma (RCC) samples to understand ...

Impact of a decision aid about stratified ovarian cancer risk-management on women's knowledge and intentions: a randomised online experimental survey study.

Meisel, SF; Freeman, M; Waller, J; Fraser, L; Gessler, S; Jacobs, I; Kalsi, J; Manchanda, R; Rahman, B; Side, L;... (2017-11-16)

BACKGROUND: Risk stratification using genetic and other types of personal information could improve current best available approaches to ovarian cancer risk reduction, improving identification of women at increased risk ...

Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency.

Hurst, CD; Alder, O; Platt, FM; Droop, A; Stead, LF; Burns, JE; Burghel, GJ; Jain, S; Klimczak, LJ; Lindsay, H;... (2017-11-13)

Bladder cancer incurs a higher lifetime treatment cost than other cancers due to frequent recurrence of non-invasive disease. Improved prognostic biomarkers and localized therapy are needed for this large patient group. ...

Noninvasive Diagnosis of Pancreatic Cancer Through Detection of Volatile Organic Compounds in Urine.

Arasaradnam, RP; Wicaksono, A; O'Brien, H; Kocher, HM; Covington, JA; Crnogorac-Jurcevic, T (2018-02)

SEARCHBreast: An online resource designed to increase the efficiency of using materials derived from breast cancer studies in animals.

Speirs, V; Morrisey, B; Holen, I; Blyth, K; Carter, P; Chelala, C; Jones, L (2016-09)

TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression.

Ottaviani, S; Stebbing, J; Frampton, AE; Zagorac, S; Krell, J; de Giorgio, A; Trabulo, SM; Nguyen, VTM; Magnani, L; Feng, H;... (2018-05-10)

TGF-β/Activin induces epithelial-to-mesenchymal transition and stemness in pancreatic ductal adenocarcinoma (PDAC). However, the microRNAs (miRNAs) regulated during this response have remained yet undetermined. Here, we ...

A risk prediction algorithm for ovarian cancer incorporating BRCA1, BRCA2, common alleles and other familial effects.

Jervis, S; Song, H; Lee, A; Dicks, E; Harrington, P; Baynes, C; Manchanda, R; Easton, DF; Jacobs, I; Pharoah, PPD;... (2015-07)

BACKGROUND: Although BRCA1 and BRCA2 mutations account for only ∼27% of the familial aggregation of ovarian cancer (OvC), no OvC risk prediction model currently exists that considers the effects of BRCA1, BRCA2 and other ...