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Haemorrhagic shock due to spontaneous splenic rupture in a patient subsequently diagnosed with advanced ovarian cancer

La Russa, M; Kokka, F; Lockley, M; Brockbank, E (2017-02)

Safety and utility of image-guided research biopsies in relapsed high-grade serous ovarian carcinoma-experience of the BriTROC consortium

Goranova, T; Ennis, D; Piskorz, AM; Macintyre, G; Lewsley, LA; Stobo, J; Wilson, C; Kay, D; Glasspool, RM; Lockley, M;... (2017-05-09)

CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma

Walton, J; Blagih, J; Ennis, D; Leung, E; Dowson, S; Farquharson, M; Tookman, LA; Orange, C; Athineos, D; Mason, S;... (2016-10)

Neoadjuvant Chemotherapy Modulates the Immune Microenvironment in Metastases of Tubo-Ovarian High-Grade Serous Carcinoma

Bohm, S; Montfort, A; Pearce, OMT; Topping, J; Chakravarty, P; Everitt, GLA; Clear, A; McDermott, JR; Ennis, D; Dowe, T;... (2016-06-15)

PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer

Fearon, AE; Carter, EP; Clayton, NS; Wilkes, EH; Baker, A-M; Kapitonova, E; Bakhouche, BA; Tanner, Y; Wang, J; Gadaleta, E;... (Elsevier/Science Direct, 2018-02-27)

Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine. Here, we show that PHLDA1 downregulation is critical to ...

Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers

Pearce, OMT; Delaine-Smith, RM; Maniati, E; Nichols, S; Wang, J; Bohm, S; Rajeeve, V; Ullah, D; Chakravarty, P; Jones, RR;... (2018-03)

Tumour-associated inflammatory cytokines are reduced following primary platinum-based chemotherapy in plasma of high-grade serous ovarian cancer patients

Boehm, S; Ennis, D; Dowe, T; Canosa, M; McNeish, I; Lockley, M; Balkwill, F (2013-09)

Ovarian cancer in adolescents and young adults.

Lockley, M; Stoneham, SJ; Olson, TA (Wiley, 2018-10-23)

The diagnosis of ovarian cancer in adolescents and young adults is always challenging. Many issues exist, and most important of these may be access to care with an appropriate provider. A range of histologies occur in the ...

Copy number signatures and mutational processes in ovarian carcinoma

Macintyre, G; Goranova, TE; De Silva, D; Ennis, D; Piskorz, AM; Eldridge, M; Sie, D; Lewsley, L-A; Hanif, A; Wilson, C;... (Nature Research (part of Springer Nature), 2018-08-13)

The genomic complexity of profound copy number aberrations has prevented effective molecular stratification of ovarian cancers. Here, to decode this complexity, we derived copy number signatures from shallow whole-genome ...

Pathological chemotherapy response score is prognostic in tubo-ovarian high-grade serous carcinoma: A systematic review and meta-analysis of individual patient data.

Cohen, PA; Powell, A; Böhm, S; Gilks, CB; Stewart, CJR; Meniawy, TM; Bulsara, M; Avril, S; Brockbank, EC; Bosse, T;... (2019-08)

OBJECTIVE: There is a need to develop and validate biomarkers for treatment response and survival in tubo-ovarian high-grade serous carcinoma (HGSC). The chemotherapy response score (CRS) stratifies patients into ...