Now showing items 1-10 of 32
PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer
(Elsevier/Science Direct, 2018-02-27)
Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine. Here, we show that PHLDA1 downregulation is critical to ...
Ovarian cancer in adolescents and young adults.
The diagnosis of ovarian cancer in adolescents and young adults is always challenging. Many issues exist, and most important of these may be access to care with an appropriate provider. A range of histologies occur in the ...
Copy number signatures and mutational processes in ovarian carcinoma
(Nature Research (part of Springer Nature), 2018-08-13)
The genomic complexity of profound copy number aberrations has prevented effective molecular stratification of ovarian cancers. Here, to decode this complexity, we derived copy number signatures from shallow whole-genome ...
Pathological chemotherapy response score is prognostic in tubo-ovarian high-grade serous carcinoma: A systematic review and meta-analysis of individual patient data.
OBJECTIVE: There is a need to develop and validate biomarkers for treatment response and survival in tubo-ovarian high-grade serous carcinoma (HGSC). The chemotherapy response score (CRS) stratifies patients into ...