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Genomic Medicine [187]
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Immune Systems [202]
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Recent Submissions
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Pulmonary epithelial barrier and immunological functions at birth and in early life - key determinants of the development of asthma? A description of the protocol for the Breathing Together study.
(Wellcome Trust, 2018-05-17)Background. Childhood asthma is a common complex condition whose aetiology is thought to involve gene-environment interactions in early life occurring at the airway epithelium, associated with immune dysmaturation. It ... -
Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition.
(National Academy of Sciences, 2018-08-27)Antibodies classically bind antigens via their complementaritydetermining regions, but an alternative mode of interaction involving V-domain framework regions has been observed for some B cell “superantigens.” We report ... -
The National CKD Audit: a primary care condition that deserves more attention.
(Royal College of General Practitioners, 2018-07-26)Chronic kidney disease (CKD) is a common condition, with an estimated prevalence in the UK of around 5–7%,1,2 and a GP recorded prevalence in the England Quality and Outcomes Framework (QOF) in 2017 of 4.1%,3 which is ... -
Can clinical prediction tools predict the need for computed tomography in blunt abdominal? A systematic review.
(Elsevier/Science Direct, 2016-06-03)INTRODUCTION: Blunt abdominal trauma is a common reason for admission to the Emergency Department. Early detection of injuries is an important goal but is often not straightforward as physical examination alone is not a ... -
Changes in neuromuscular structure and functions of human colon during ageing are region-dependent.
(BMJ Publishing Group, 2018-09-18)Objective: To determine if human colonic neuromuscular functions decline with increasing age. Design: Looking for non-specific changes in neuromuscular function, a standard burst of electrical field stimulation (EFS) was ...
