Blizard Institute
The Blizard Institute is the largest institute of Barts and The London School of Medicine and Dentistry. It's research and education span broad areas of modern biomedicine, with particular expertise in cell biology, genomics, immunology, neuroscience, primary care, population health and trauma sciences.
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Centre for Immunobiology [1262]
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Recent Submissions
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Extended Risankizumab Treatment in Patients With Crohn's Disease Who Did Not Achieve Clinical Response to Induction Treatment.
(Elsevier, 2025-02-03)BACKGROUND AND AIMS: The efficacy and safety of extended treatment with risankizumab (RZB), an anti-interleukin-23 p19 monoclonal antibody, were evaluated in patients with moderate to severe Crohn's disease (CD) who did ... -
Replicating Dynamic Immune Responses at Single-Cell Resolution within a Microfluidic Human Skin Equivalent.
(Wiley, 2025-01-21)To enable in vitro investigation of human skin immunology, this study develops a microfluidic human skin equivalent (HSE) that supports the delivery of circulating immune cells via a vascular microchannel embedded within ... -
Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets.
(Springer Nature, 2025-02-07)BACKGROUND: Glioblastoma is the most common and aggressive malignant brain tumour in the adult population and its prognosis is dismal. The heterogeneous nature of the tumour, to which epigenetic dysregulation significantly ... -
Maternal views on RSV vaccination during the first season of implementation in England and Scotland.
(Elsevier, 2025-01-29) -
The incidence and outcomes of hyperacute cardiovascular dysfunction following isolated traumatic brain injury: an observational cohort study.
(2025-02-04)BACKGROUND: The relationship between early cardiovascular dysfunction (CVD) in isolated traumatic brain injury (iTBI) and outcome has not been fully described. We aimed to (1) determine the prevalence and phenotype of CVD ... -
Grandmothers: Central scaffolding sources impacting maternal and infant feeding practices in Colombia.
(Wiley, 2021-07-09)A growing body of evidence highlights that maternal and child nutrition programmes need to extend beyond the mother-child dyad by adopting a family systems approach, particularly in the Global South. Guided by a sociocultural ... -
Resisting epistemic violence in global mental health: Listening to local understandings of mental health and emotional distress among victims and ex-guerrilla members in Southern Colombia
(Elsevier, 2024-12-21)Background: While there is consensus that local knowledge is important to build better mental health responses, integration of this knowledge into mental health services remains a work in progress. In this paper, we explore ... -
Treatment and Outcome in Children With Tuberculous Meningitis: A Multicenter Pediatric Tuberculosis Network European Trials Group Study.
(Oxford University Press, 2021-11-27)BACKGROUND: Currently, data on treatment, outcome, and prognostic factors in children with tuberculous meningitis (TBM) in Europe are limited. To date, most existing data on TBM originate from adult studies, or studies ... -
Research as part of the advanced clinical practitioner role.
(Mark Allen Group, 2022-04-07) -
Feasibility within-subject RCT of neuromuscular electrical stimulation; an Intervention to Maintain and improve neuroMuscular function during period of Immobility (IMMI).
(Springer Nature, 2025-01-08)INTRODUCTION: Neuromuscular electrical stimulation (NMES) is a potentially effective intervention to improve outcomes after a fragility fracture, but its feasibility in this group has not been established. METHODS: A ... -
Assessing the feasibility of measuring residents' quality of life in English care homes and the construct validity and internal consistency of measures completed by staff proxy: a cross-sectional study.
(BMJ Publishing Group, 2025-01-29)OBJECTIVES: To assess the feasibility of capturing older care home residents' quality of life (QoL) in digital social care records and the construct validity (hypothesis testing) and internal consistency (Cronbach's alpha) ... -
AI and machine learning for detection and management of delirium in care home residents
(Karger Publishers, 2025-01-27) -
Towards a common definition of hospital-acquired deconditioning in adults: a scoping review.
(BMJ Publishing Group, 2025-01-15)BACKGROUND: Hospital-acquired deconditioning is a term used in clinical practice, describing a loss of physical and/or cognitive function associated with hospitalisation. Previous reviews have addressed interventions, its ... -
P1321 Inflammatory bowel disease and the rural to urban microbiome transition in Zambia
(Oxford University Press (OUP), 2025-01-22) -
Comparison of clinical outcomes between active and permissive blood pressure management in extremely preterm infants
(National Institute for Health and Care Research, 2023-01-24) -
Common carotid artery blood flow volume in extremely preterm infants
(Wiley, 2020-11-20) -
Comparison of clinical outcomes between active and permissive blood pressure management in extremely preterm infants.
(National Institute for Health and Care Research, 2023-05-10)BACKGROUND: There remains uncertainty about the definition of normal blood pressure (BP), and when to initiate treatment for hypotension for extremely preterm infants. To determine the short-term outcomes of extremely ...