• Simplified monitoring for hepatitis C virus treatment with glecaprevir plus pibrentasvir, a randomised non-inferiority trial 

  Dore, GJ; Feld, JJ; Thompson, A; Martinello, M; Muir, AJ; Agarwal, K; Mullhaupt, B; Wedemeyer, H; Lacombe, K; Matthews, GV (2020-03)

• Baseline neutrophil-to-lymphocyte ratio predicts response to corticosteroids and is associated with infection and renal dysfunction in alcoholic hepatitis 

  Forrest, EH; Storey, N; Sinha, R; Atkinson, SR; Vergis, N; Richardson, P; Masson, S; Ryder, S; Thursz, MR; Allison, M (2019-08)

• Cost-Effectiveness Analysis of Baseline Testing for Resistance-Associated Polymorphisms to Optimize Treatment Outcome in Genotype 1 Noncirrhotic Treatment-Naive Patients With Chronic Hepatitis C Virus 

  Fawsitt, CG; Vickerman, P; Cooke, GS; Welton, NJ; Barnes, E; Ball, J; Brainard, D; Burgess, G; Dillon, J; Foster, G (2020-02)

• Unacceptable failures: the final report of the Lancet Commission into liver disease in the UK 

  Williams, R; Aithal, G; Alexander, GJ; Allison, M; Armstrong, I; Aspinall, R; Baker, A; Batterham, R; Brown, K; Burton, R (2020-01-18)

• KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity 

  Turberfield, A; Kondo, T; Nakayama, M; Koseki, Y; King, H; Koseki, H; Klose, R (Oxford University Press, 2019-07-31)

  ABSTRACT CpG islands (CGI) are associated with the majority of mammalian gene promoters and function to recruit chromatin modifying enzymes. It has therefore been proposed that CGIs regulate gene expression through ...

• KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity 

  Turberfield, AH; Kondo, T; Nakayama, M; Koseki, Y; King, HW; Koseki, H; Klose, RJ (Oxford University Press, 2019-09-26)

  CpG islands (CGIs) are associated with the majority of mammalian gene promoters and function to recruit chromatin modifying enzymes. It has therefore been proposed that CGIs regulate gene expression through chromatin-based ...

• Germs and germlines: how "public" B-cell clones evolve in the gut. 

  James, KR; King, HW (2020-05-16)

  Chen et al. describe how B-cell clones observed in the gut of many different individuals (recurrent or "public" clonotypes) are shaped by the combined influences of common microbial antigens and underlying genomic recombination ...

• Physics of Within-Tissue Wave Propagation Generated by Pulse Propagation in the Carotid Artery 

  Tommasin, D; Caenen, A; Verhegghe, B; Greenwald, S; Segers, P (MDPI, 2019-07-18)

  Background: We aimed to assess the validity of laser Doppler vibrometry (LDV) as an emerging method to measure the local pulse wave velocity (PWV) from skin displacement generated by the pressure pulse inside an underlying ...

• CB1 antagonists SR141617A and AM251 stimulate insulin secretion from mouse and human islets 

  Ruz-Maldonado, I; Liu, B; Atanes, P; Pingitore, A; Huang, GC; Baker, D; Persaud, SJ (Wiley Online, 2018-03-14)

  Aims: Cannabinoid receptor type 1 (CB1) and G protein‐coupled receptor 55 (GPR55) are G protein‐coupled receptors (GPCRs) expressed by islet beta cells that are coupled to regulation of insulin secretion. In this study, ...

• Memory B Cells: Toward a Unified Therapeutic Target for Effective Immunotherapy in Multiple Sclerosis 

  Ceronie, B; Dubuisson, N; Ammoscato, F; Baker, D; Giovannoni, G; Schmierer, K (Lippincott, Williams & Wilkins, 2018-04-09)

  Objective: We characterised the peripheral memory B cell pool (CD19+/CD27+), as well as class-switched (IgD−), non-switched (IgD+) and Interleukin-2 receptor positive (CD25+) subsets of memory B cells in multiple sclerosis ...

• MEMORY B CELLS ARE KEY FOR IMMUNOTHERAPY IN MULTIPLE SCLEROSIS 

  Schmierer, K; Marta, M; Pryce, G; Giovannoni, G; Baker, D (BMJ Publishing Group Ltd, 2017-12-01)

  Although multiple sclerosis (MS) is considered to be a CD4+,Th17-mediated autoimmune disease, supportive evidence is largely circumstantial and often based on animal studies. Whilst alemtuzumab inhibits relapsing MS and ...

• SARS-CoV-2 and Multiple Sclerosis: Not all immune depleting DMTs are equal or bad. 

  Amor, S; Baker, D; Khoury, SJ; Schmierer, K; Giovanonni, G (Wiley Online, 2020-05-08)

  A major concern during the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic1 is the use of immunosuppressive therapies for the treatment of multiple sclerosis (MS) due to an increased risk of ...

• The underpinning biology relating to multiple sclerosis disease modifying treatments during the COVID-19 pandemic 

  Baker, D; Amor, S; Kang, AS; Schmierer, K; Giovannoni, G (Elsevier BV, 2020-05-12)

  Background : SARS-CoV-2 viral infection causes COVID-19 that can result in severe acute respiratory distress syndrome (ARDS), which can cause significant mortality, leading to concern that immunosuppressive treatments for ...

• Use of the Harmonic scalpel for Delorme's procedure 

  Pares, D; Drami, I; Adams, K; Grossi, U; Suliman, I; Knowles, CH (Wiley Online, 2017-04-18)

  Aim There are many surgical techniques that deal withexternal rectal prolapse but perineal procedures have theadvantage of reduced invasiveness. Therefore, despiteconcerns regarding high recurrence rates, the techniqueis ...

• Ultra-late recurrence of gastrointestinal stromal tumour: case report and literature review 

  Grossi, U; Ardito, F; Ciavarella, LP; Goglia, M; Giuliante, F (Wiley Online, 2017-12-01)

  A 79‐year‐old Caucasian man presented with a 2‐month history of central abdominal pain. An ultrasound revealed an 11 × 7 cm lesion in the segments 5 and 6 of the liver subsequently confirmed on computed tomography (Fig. ...

• Gatekeeper Improves Voluntary Contractility in Patients With Fecal Incontinence 

  Grossi, U; De Simone, V; Parello, A; Litta, F; Donisi, L; Luca Di Tanna, G; Goglia, M; Ratto, C (Sage Publications, 2018-12-14)

  Background. Gatekeeper (GK) has shown to be safe and effective in patients with fecal incontinence (FI). We aimed to understand its mechanism of action by comparing pre- and post-implant change in the external anal sphincter ...

• Contemporary surgical practice in the management of anal fistula: results from an international survey 

  Ratto, C; Grossi, U; Litta, F; Di Tanna, GL; Parello, A; De Simone, V; Tozer, P; De Zimmerman, D; Maeda, Y (Springer Nature Switzerland AG, 2019-07-31)

  Background Management of anal fstula (AF) remains challenging with many controversies. The purpose of this study was to explore current surgical practice in the management of AF with a focus on technical variations among ...

• Recalled stapler device, high complication rate, non validated scoring system and misquote from the STARR surgeons 

  Grossi, U; Mercer-Jones, M; Di Tanna, GL; Knowles, CH (Springer Nature Switzerland AG, 2019-08-26)

  Dear Sir, We read with great interest the prospective cohort study by Giarratano et al. [1] recently published in this journal. The authors reported the outcomes of 262 consecutive patients undergoing stapled transanal ...

• Fistulotomy and primary sphincteroplasty for anal fistula: long-term data on continence and patient satisfaction. 

  Litta, F; Parello, A; De Simone, V; Grossi, U; Orefice, R; Ratto, C (Springer Nature Switzerland AG, 2019-09-19)

  BACKGROUND: The aim of this study was to evaluate the safety and long-term efficacy of fistulotomy and primary sphincteroplasty (FIPS). Secondary endpoints were its impact on postoperative continence status and patients' ...

• Sister Mary Joseph's nodule and colorectal cancer: an aggressive treatment for an aggressive disease. 

  Grossi, U; Petracca Ciavarella, L; Fuso, P; Crucitti, A (Wiley Online, 2019-11-28)

  A 60‐year‐old Caucasian man presented with a 6‐month history of pruritic erythematous umbilical papules, which rapidly worsened in 2 weeks to become ulcerated nodules (Fig. 1a). Serum tumour marker assay performed at the ...

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