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Estimated glomerular filtration rate is an early biomarker of cardiac surgery-associated acute kidney injury
(2018-11-27)© 2018 Sociedad Española de Nefrología Background: Acute kidney injury (AKI) diagnosis is still based on serum creatinine and diuresis. However, increases in creatinine are typically delayed 48 h or longer after injury. ... -
Why, who and when to start treatment for chronic hepatitis B infection.
(Elsevier, 2018-04-11)Chronic hepatitis B remains a major global health challenge due to morbidity and mortality from hepatocellular carcinoma and complications of liver cirrhosis. Current treatment regimens are non-curative and, once initiated, ... -
Prevalence and determinants of QuantiFERON-diagnosed tuberculosis infection in 9,810 Mongolian schoolchildren.
(2018-11-27)Background: There is controversy regarding the potential influence of vitamin D deficiency, exposure to environmental tobacco smoke, BCG vaccination, season and body habitus on susceptibility to Mycobacterium tuberculosis ... -
Childhood asthma prevalence: cross-sectional record linkage study comparing parent-reported wheeze with general practitioner-recorded asthma diagnoses from primary care electronic health records in Wales.
(2018)Introduction: Electronic health records (EHRs) are increasingly used to estimate the prevalence of childhood asthma. The relation of these estimates to those obtained from parent-reported wheezing suggestive of asthma is ... -
Functional brain networks and neuroanatomy underpinning nausea severity can predict nausea susceptibility using machine learning.
(2019-01-10)KEY POINTS: Nausea is an adverse experience characterised by alterations in autonomic and cerebral function. Susceptibility to nausea is difficult to predict, but machine learning has yet to be applied to this field of ... -
T-bet controls intestinal mucosa immune responses via repression of type 2 innate lymphoid cell function
(Springer Nature, 2018-10-24)Innate lymphoid cells (ILCs) play a crucial role in early mucosal immune defence, inflammation and tissue remodelling.1 Based on the transcription factors that govern their differentiation, function and signature cytokine ... -
Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.
(Wiley Online, 2018-01-03)Abstract Introduction Impaired proliferation and production of IL2 are the hallmarks of experimental T cell tolerance. However, in most autoimmune diseases, auto‐reactive T cells do not display hyper proliferation, but ... -
Transfusion strategies for major haemorrhage in trauma.
(Wiley Online, 2018-12-27)Trauma is a leading cause of death worldwide in personsunder 44 years of age, and uncontrolled haemorrhage is themost common preventable cause of death in this patientgroup. The transfusion management of trauma haemorrhageis ... -
IMP2ART systematic review of education for healthcare professionals implementing supported self-management for asthma.
(2018-11-06)Despite a robust evidence base for its effectiveness, implementation of supported self-management for asthma is suboptimal. Professional education is an implementation strategy with proven effectiveness, though the specific ... -
Correction: The Use of International Classification of Diseases Codes to Identify Patients with Pancreatitis: A Systematic Review and Meta-analysis of Diagnostic Accuracy Studies.
(2018-11-21)The original version of this Article presented incorrect information for citation 50. This has now been corrected in both the PDF and HTML versions of the Article. Petrov, M. S. Predicting the severity of acute pancreatitis: ... -
Characterization of a colistin-resistant Avian Pathogenic Escherichia coli ST69 isolate recovered from a broiler chicken in Germany.
(2019-01)In recent years, several plasmids harbouring genes encoding phosphoethanolamine transferases conferring colistin resistance have been described in multiple Enterobacteriaceae species. Avian Pathogenic E. coli (APEC) causes ... -
The Distribution of the EQ-5D-5L Profiles and Values in Three Patient Groups
(2019-01-01)© 2018 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Background: The distribution of EQ-5D-3L values (health state profiles, weighted by value sets) often shows two distinct groups, arising from ... -
Intestinal Dendritic Cells in Health and Gut Inflammation.
(Frontiers Media SA, 2018-12-06)Dendritic cells (DCs) mediate tolerance to food antigens, limit reactivity to the gut microbiota and are required for optimal response to intestinal pathogens. Intestinal DCs are heterogeneous but collectively generate ... -
The impact of currently licensed therapies on viral and immune responses in Chronic Hepatitis B: considerations for future novel therapeutics.
(Blackwell publishing, 2018-11-11)Despite the availability of a preventative vaccine, chronic hepatitis B (CHB) remains a global healthcare challenge with the risk of disease progression due to cirrhosis and hepatocellular carcinoma. Although current ... -
BRain health and healthy AgeINg in retired rugby union players, the BRAIN Study: study protocol for an observational study in the UK.
(2017-12-26)INTRODUCTION: Relatively little is known about the long-term health of former elite rugby players, or former sportspeople more generally. As well as the potential benefits of being former elite sportspersons, there may be ... -
Interventions to improve oral vaccine performance in developing countries: a systematic review and meta-analysis
Background: Oral vaccines underperform in developing compared to developed countries. Whether interventions can improve oral vaccine performance remains uncertain. Methods: We did a systematic review and meta-analysis ...
