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Idiopathic slow transit constipation and megacolon are not associated with neurturin mutations.
(Wiley, 2002-10-02)Chronic idiopathic slow-transit constipation (ISTC) and idiopathic megacolon (IMC) are early-onset gastrointestinal motility disorders of unknown aetiology. The gene encoding the neurotrophic factor neurturin may be a ... -
Causes and Timing of Mortality and Morbidity Among Late Presenters Starting Antiretroviral Therapy in the REALITY Trial.
(Oxford University Press (OUP), 2018-03-04)Background: In sub-Saharan Africa, 20%-25% of people starting antiretroviral therapy (ART) have severe immunosuppression; approximately 10% die within 3 months. In the Reduction of EArly mortaLITY (REALITY) randomized ... -
Randomised clinical trial: Bifidobacterium lactis NCC2818 probiotic vs placebo, and impact on gut transit time, symptoms, and gut microbiology in chronic constipation
(Wiley, 2019-12-25)Background: Constipation is a prevalent gastrointestinal disorder. Patient dissatisfaction with prescribed medications is common, and there is need for alternative management strategies. Evidence shows that Bifidobacterium ... -
Ambulatory assessment of colonic motility using the electromagnetic capsule tracking system.
(2019-02)BACKGROUND: The Motilis 3D-Transit system tracks electromagnetic capsules as they traverse the gastrointestinal tract. The method is minimally invasive and ambulatory. Analysis has previously been limited to regional gut ... -
High-resolution Anorectal Manometry Measures Are More Accurate Than Conventional Measures in Detecting Anal Hypocontractility in Women With Fecal Incontinence.
(Elsevier, 2018-06-30)BACKGROUND & AIMS: Anorectal manometry is a common test of anal tone and contractility. However, existing measures are often criticized for their poor ability to detect functional differences between individuals with ... -
Probiotic use is common in constipation, but only a minority of general and specialist doctors recommend them and consider there to be an evidence base.
(Elsevier, 2018-11-23)OBJECTIVES: This study aimed to assess the use and perceived effectiveness of probiotics by the general population (with or without self-reported constipation), and their recommendation and perceived effectiveness by general ... -
Impact of rural Family Physician programme on maternal and child health indicators in Iran: an interrupted time series analysis.
(BMJ Publishing Group Ltd, 2019-01-15)OBJECTIVES: The establishment of the Family Physician (FP) programme in the rural areas of Iran in 2005 has made health services accessible and affordable. This paper aims to assess the overall trends of maternal and child ... -
Social capital: Implications for neurology.
(2019-01)Social capital (SC) is a broad term that encompasses the many resources derived from social connections. The contemporary study of SC in public health has deep roots in the related fields of sociology, economics, and ... -
Optimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) trial: study protocol for a multicentre international trial of cardiac output-guided fluid therapy with low-dose inotrope infusion compared with usual care in patients undergoing major elective gastrointestinal surgery.
(BMJ Publishing Group Ltd, 2019-01-15)INTRODUCTION: Postoperative morbidity and mortality in older patients with comorbidities undergoing gastrointestinal surgery are a major burden on healthcare systems. Infections after surgery are common in such patients, ... -
Pharmacokinetic-pharmacodynamic modelling to investigate in vitro synergy between colistin and fusidic acid against MDR Acinetobacter baumannii.
(Oxford University Press, 2019-01-08)Objectives: The potential for synergy between colistin and fusidic acid in the treatment of MDR Acinetobacter baumannii has recently been shown. The aim of this study was to perform an extensive in vitro characterization ... -
Response to: How to design and analyse cluster randomized trials with a small number of clusters? Comment on Leyrat et al.
(Oxford University Press, 2018-04-18) -
Independent and combined effects of improved water, sanitation, and hygiene, and improved complementary feeding, on child stunting and anaemia in rural Zimbabwe: a cluster-randomised trial.
(Elsevier, 2019-01)BACKGROUND: Child stunting reduces survival and impairs neurodevelopment. We tested the independent and combined effects of improved water, sanitation, and hygiene (WASH), and improved infant and young child feeding (IYCF) ... -
Risks of psychiatric disorders in children and young adults with demyelinating diseases of the central nervous system: a national record-linkage study.
(Lippincott, Williams & Wilkins, 2017-04-17)Objective: To assess the risk of psychiatric disorders in children with multiple sclerosis (MS) and other CNS demyelinating diseases, and vice versa. Background: The profile of psychiatric disorders associated with MS ... -
EFFECTS OF HEALTH INSURANCE ON LABOUR SUPPLY: A SYSTEMATIC REVIEW
(Emerald, 2018)Purpose – The purpose of this paper is to provide a systematic review of empirical evidence on the labour market effects of health insurance from the supply side. Design/methodology/approach – The study covers the largest ... -
Abiraterone Acetate for the Treatment of Chemotherapy-Naive Metastatic Castration-Resistant Prostate Cancer: An Evidence Review Group Perspective of an NICE Single Technology Appraisal
(Springer Link, 2016-08-26)The National Institute for Health and Care Excellence (NICE) invited Janssen, the company manufacturing abiraterone acetate (AA; tradename Zytiga®), to submit evidence for the clinical and cost effectiveness of AA in ... -
Response to Letter to the Editor Regarding "Abiraterone Acetate for the Treatment of Chemotherapy-Naive Metastatic Castration-Resistant Prostate Cancer: An Evidence Review Group Perspectiveaof a NICE Single Technology Appraisal"
(Springer Link, 2017-04-08)Dear Editors, We very much appreciate the interest Reifsnider et al. [1] have taken in our perspective on the single technology appraisal (STA) of abiraterone acetate (tradename Zytiga®) plus prednisolone (AAP) acetate ... -
Actigraph Accelerometer-Defined Boundaries for Sedentary Behaviour and Physical Activity Intensities in 7 Year Old Children
(Public Library of Science, 2011-08-11)Background: Accurate objective assessment of sedentary and physical activity behaviours during childhood is integral to the understanding of their relation to later health outcomes, as well as to documenting the frequency ... -
The WPA-Lancet Psychiatry Commission on the Future of Psychiatry
(Elsevier, 2017-10)Background This Commission addresses several priority areas for psychiatry over the next decade, and into the 21st century. These represent challenges and opportunities for the profession to sustain and develop itself to ... -
IgE binds asymmetrically to its B cell receptor CD23.
(Nature Research (part of Springer Nature), 2017-03-31)The antibody IgE plays a central role in allergic disease mechanisms. Its effector functions are controlled through interactions between the Fc region and two principal cell surface receptors FcεRI and CD23. The interaction ...
