Centre for Immunobiology
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The Centre for Immunobiology combines top-quality research and education in immunology, with particular focus on acute and chronic inflammatory disease, lymphocyte development, and the mucosal immune system.
Recent Submissions
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Barriers and enablers to the effective implementation of omics research in low- and middle-income countries.
(Nature Research, 2024-06-17) -
Multicentre service evaluation of injectable cabotegravir and rilpivirine delivery and outcomes across 12 UK clinics (SHARE LAI-net)
(Wiley, 2024-06-10)Introduction Long-acting injectable cabotegravir + rilpivirine (CAB + RPV LAI) was approved for use in virally suppressed adults in the England and Wales national health service in November 2021. We describe a service ... -
MAVMET trial: maraviroc and/or metformin for metabolic dysfunction-associated fatty liver disease(MAFLD) in adults with suppressed HIV.
(2024-05-31)OBJECTIVE: Metabolic dysfunction-associated fatty liver disease (MAFLD) is over-represented in people living with HIV (PLWH). Maraviroc (MVC) and/or metformin (MET) may reduce MAFLD by influencing inflammatory pathways and ... -
A wireless semi-wearable sensor for assessment of gut function in low-resource settings
(SPIE, the international society for optics and photonics, 2024-03-13)Environmental enteric dysfunction (EED) is a subclinical disorder of intestinal function common in tropical countries and settings of poverty and economic disadvantage. EED manifests during infancy and is associated with ... -
The role of circulating T cells with a tissue resident phenotype (ex-TRM) in health and disease
(Frontiers, 2024-05-16)Tissue-resident memory T cells (TRM) are long-lived memory lymphocytes that persist in non-lymphoid tissues and provide the first line of defence against invading pathogens. They adapt to their environment in a tissue-specific ... -
P145 Phagocyte responses to gut-derived C. albicans are modified in inflammatory bowel disease
(Oxford University Press (OUP), 2024-01-24) -
γδ T cells respond directly and selectively to the skin commensal yeast Malassezia for IL-17-dependent fungal control.
(2024-01)Stable microbial colonization of the skin depends on tight control by the host immune system. The lipid-dependent yeast Malassezia typically colonizes skin as a harmless commensal and is subject to host type 17 immunosurveillance, ... -
Refining DNA Barcoding Coupled High Resolution Melting for Discrimination of 12 Closely Related Croton Species.
(2015)DNA barcoding coupled high resolution melting (Bar-HRM) is an emerging method for species discrimination based on DNA dissociation kinetics. The aim of this work was to evaluate the suitability of different primer sets, ... -
Computational workflow for investigating highly variable genes in single-cell RNA-seq across multiple time points and cell types.
(2023-09-15)Here, we present a computational approach for investigating highly variable genes (HVGs) associated with biological pathways of interest, across multiple time points and cell types in single-cell RNA-sequencing (scRNA-seq) ... -
Antisense Oligonucleotide Induction of the hnRNPA1b Isoform Affects Pre-mRNA Splicing of SMN2 in SMA Type I Fibroblasts.
(2022-04-01)Spinal muscular atrophy (SMA) is a severe, debilitating neuromuscular condition characterised by loss of motor neurons and progressive muscle wasting. SMA is caused by a loss of expression of SMN1 that encodes the survival ... -
Single-cell temporal analysis of natural dengue infection reveals skin-homing lymphocyte expansion one day before defervescence.
(2022-04-15)Effective clinical management of acute dengue virus (DENV) infection relies on the timing of suitable treatments during the disease progression. We analyzed single-cell transcriptomic profiles of the peripheral blood ... -
Perinatal thymic-derived CD8alphabeta-expressing gammadelta T cells are innate interferon-gamma producers that expand in IL-7R/STAT5B-driven neoplasms
(Nature Research, 27-05-2024)The contribution of γδ T cells to immune responses is associated with rapid secretion of interferon-γ (IFN-γ). Here, we show a perinatal thymic wave of innate IFN-γ-producing γδ T cells that express CD8αβ heterodimers and ... -
Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and impacts clinical response
(American Society for Clinical Investigation, 17-06-2024)Ectopic lymphoid structures (ELSs) in the rheumatoid synovial joints sustain autoreactivity against locally expressed autoantigens. We recently identified recombinant monoclonal antibodies (RA-rmAbs) derived from single, ... -
Malnutrition enteropathy in Zambian and Zimbabwean children with severe acute malnutrition: A multi-arm randomized phase II trial.
(2024-04-17)Malnutrition underlies almost half of all child deaths globally. Severe Acute Malnutrition (SAM) carries unacceptable mortality, particularly if accompanied by infection or medical complications, including enteropathy. We ... -
Chemical disinfection as a simple and reliable method to control the amphibian chytrid fungus at breeding points of endangered amphibians.
(2024-03-02)Chytridiomycosis caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd) is pushing amphibians towards extinction. Whilst mitigation methods were suggested a decade ago, we lack field trials testing their efficacy. ... -
Endoscopic diagnosis of gastric and oesophageal cancer in Lusaka, Zambia: a retrospective analysis.
(BMC, 2024-04-01)INTRODUCTION: There are uncertainties surrounding the spectrum of upper gastrointestinal (UGI) diseases in sub-Saharan Africa. This is mainly due to the limitations of data collection and recording. We previously reported ... -
Prevalence of Clarithromycin-Resistant Helicobacter pylori Strains in Zambia: A Sub-Saharan African Country.
(Karger Publishers, 2024-01-05)INTRODUCTION: Helicobacter pylori (H. pylori) is one of the most important infections globally, affecting more than 50% of the human population. Clarithromycin (CLA)-containing regimens are recommended for empirical ...