• Peanut diversity and specific activity are the dominant IgE characteristics for effector cell activation in children. 

  Hemmings, O; Niazi, U; Kwok, M; James, LK; Lack, G; Santos, AF (2021-03-03)

  BACKGROUND: IgE mediates allergic reactions to peanut; however, peanut-specific IgE (sIgE) levels do not always equate to clinical peanut allergy. Qualitative differences between sIgE of peanut sensitised but tolerant (PS) ...

• Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis 

  Park, JE; JebaMercy, G; Pazhanchamy, K; Guo, X; Ngan, SC; Liou, KCK; Lynn, SE; Ng, SS; Meng, W; Lim, SC (Elsevier, 2021-03-01)

• Effects of Bovine Colostrum with or without Egg on In Vitro Bacterial-Induced Intestinal Damage with Relevance for SIBO and Infectious Diarrhea. 

  Playford, RJ; Choudhry, N; Kelly, P; Marchbank, T (MDPI, 2021-03-22)

  Small intestinal bacterial overgrowth (SIBO) occurs commonly, is difficult to treat, and frequently recurs. Bovine colostrum (BC) and chicken eggs contain immunoglobulins and other components that possess antimicrobial, ...

• The contribution of environmental enteropathy to the global problem of micronutrient deficiency. 

  Kelly, P (Cambridge University Press, 2021-03-05)

  Sometimes referred to as hidden hunger, micronutrient deficiencies persist on a global scale. For some micronutrients this appears to be due to inadequate intake, for others intake may not match increased requirements. ...

• Use-case scenarios for an anti-Cryptosporidium therapeutic. 

  Ashigbie, PG; Shepherd, S; Steiner, KL; Amadi, B; Aziz, N; Manjunatha, UH; Spector, JM; Diagana, TT; Kelly, P (Public Library of Science, 2021-03-11)

  Cryptosporidium is a widely distributed enteric parasite that has an increasingly appreciated pathogenic role, particularly in pediatric diarrhea. While cryptosporidiosis has likely affected humanity for millennia, its ...

• Comprehensive mapping of tissue cell architecture via integrated single cell and spatial transcriptomics 

  Kleshchevnikov, V; Shmatko, A; Dann, E; Aivazidis, A; King, HW; Li, T; Lomakin, A; Kedlian, V; Jain, MS; Park, JS (Cold Spring Harbor Laboratory, 2020)

  The spatial organization of cell types in tissues fundamentally shapes cellular interactions and function, but the high-throughput spatial mapping of complex tissues remains a challenge. We present сell2location, a principled ...

• Diagnostic Pitfalls of Urogenital Tuberculosis. 

  Chandran, S; Rahman, A; Norris, JM; Tiberi, S; Kunst, H (2021-04-04)

  OBJECTIVES: To describe characteristics, details of diagnosis and outcomes of urogenital tuberculosis (UGTB) in a low prevalence country. METHODS: We conducted a retrospective observational study of 37 consecutive patients ...

• Non tuberculous mycobacteria pulmonary disease: patients and clinicians working together to improve the evidence base for care 

  Lipman, M; Kunst, H; Loebinger, MR; Milburn, HJ; King, M (Elsevier, 2021-03-26)

• “You have to change your whole life”: a qualitative study of the dynamics of treatment adherence among adults with tuberculosis in the United Kingdom 

  Karat, AS; Jones, AS; Abubakar, I; Campbell, CN; Clarke, AL; Clarke, CS; Darvell, M; Hill, AT; Horne, R; Kunst, H (2021-03-01)

• Screening for tuberculosis among high-risk groups attending London Emergency Departments: A prospective observational study. 

  Gupta, RK; Lule, SA; Krutikov, M; Gosce, L; Green, N; Southern, J; Imran, A; Aldridge, RW; Kunst, H; Lipman, M (European Respiratory Society, 2021-03-18)

• Outcome of treatment of MDR-TB or drug-resistant patients treated with bedaquiline and delamanid: Results from a large global cohort. 

  Koirala, S; Borisov, S; Danila, E; Mariandyshev, A; Shrestha, B; Lukhele, N; Dalcolmo, M; Shakya, SR; Miliauskas, S; Kuksa, L (2021-03-19)

  The World Health Organization (WHO) recommends countries introduce new anti-TB drugs in the treatment of multidrug-resistant tuberculosis. The aim of the study is to prospectively evaluate the effectiveness of bedaquiline ...

• Integrated single-cell transcriptomics and epigenomics reveals strong germinal center-associated etiology of autoimmune risk loci 

  King, H; Wells, K; Shipony, Z; Kathiria, A; Wagar, L; Lareau, C; Orban, N; Capasso, R; Davis, M; Steinmetz, L (2021-03-17)

  This article is a preprint and has not been certified by peer review. The germinal center (GC) response is critical for both effective adaptive immunity and establishing peripheral tolerance by limiting auto-reactive B ...

• Cyclooxygenases and the cardiovascular system 

  Mitchell, JA; Kirkby, NS; Ahmetaj-Shala, B; Armstrong, PC; Crescente, M; Ferreira, P; Pires, MEL; Vaja, R; Warner, TD (2021-01)

• TB management in the European Union/European Economic Area: a multi‐centre survey 

  Sotgiu, G; Rosales-Klintz, S; Centis, R; D'Ambrosio, L; Verduin, R; Correia, AM; Cirule, A; Duarte, R; Gadzheva, B; Gualano, G (International Union Against Tuberculosis and Lung Disease, 2021-02-01)

• Antibody repertoire and gene expression dynamics of diverse human B cell states during affinity maturation 

  King, H; Orban, N; Riches, J; Clear, A; Warnes, G; Teichmann, S; James, L (2020-04-30)

  Pre-print (not been peer-reviewed). Now published in Science Immunology doi: 10.1126/sciimmunol.abe6291 . Abstract: In response to antigen challenge, B cells clonally expand, undergo selection and differentiate to ...

• Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics. 

  King, HW; Orban, N; Riches, JC; Clear, AJ; Warnes, G; Teichmann, SA; James, LK (2021-02-12)

  Protective humoral memory forms in secondary lymphoid organs where B cells undergo affinity maturation and differentiation into memory or plasma cells. Here, we provide a comprehensive roadmap of human B cell maturation ...

• Switching from boosted PIs to dolutegravir in HIV-infected patients with high cardiovascular risk: 48 week effects on subclinical cardiovascular disease. 

  Gonzalez-Cordon, A; Assoumou, L; Camafort, M; Domenech, M; Guaraldi, G; Domingo, P; Rusconi, S; Raffi, F; Katlama, C; Masia, M (2020-11-01)

  BACKGROUND: Switching from boosted PIs to dolutegravir in virologically suppressed HIV-infected patients with high cardiovascular risk significantly decreased total cholesterol and other proatherogenic lipid fractions at ...

• Sustained viral suppression among participants with pre-existing M184V/I who switched to bictegravir/emtricitabine/tenofovir alafenamide 

  Andreatta, K; Acosta, R; D'Antoni, M; Porter, D; Chang, S; Martin, R; Willkom, M; McNicholl, I; Gallant, J; Pikora, C (2020-11)

• Safety and Efficacy of Ombitasvir, Paritaprevir With Ritonavir ± Dasabuvir With or Without Ribavirin in Patients With Human Immunodeficiency Virus-1 and Hepatitis C Virus Genotype 1 or Genotype 4 Coinfection: TURQUOISE-I Part 2. 

  Rockstroh, JK; Orkin, C; Viani, RM; Wyles, D; Luetkemeyer, AF; Lazzarin, A; Soto-Malave, R; Nelson, MR; Bhagani, SR; Klinker, HHF (2017)

  BACKGROUND: Ombitasvir, paritaprevir with ritonavir, and dasabuvir (OBV/PTV/r ± DSV) ±ribavirin (RBV) are approved to treat hepatitis C virus (HCV) genotype 1 and 4 infection. Here, we investigate the safety and efficacy ...

• Long-Acting Injectable Cabotegravir plus Rilpivirine for HIV Maintenance Therapy: Week 48 Pooled Analysis of Phase 3 ATLAS and FLAIR Trials 

  Rizzardini, G; Overton, ET; Orkin, C; Swindells, S; Arasteh, K; Gorgolas Hernandez-Mora, M; Pokrovsky, V; Girard, P-M; Oka, S; Andrade-Villanueva, JF (2020-12-01)

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