Blizard Institute: Recent submissions
Now showing items 1-20 of 6060
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Comparison of clinical outcomes between active and permissive blood pressure management in extremely preterm infants
(National Institute for Health and Care Research, 2023-01-24) -
Common carotid artery blood flow volume in extremely preterm infants
(Wiley, 2020-11-20) -
Comparison of clinical outcomes between active and permissive blood pressure management in extremely preterm infants.
(National Institute for Health and Care Research, 2023-05-10)BACKGROUND: There remains uncertainty about the definition of normal blood pressure (BP), and when to initiate treatment for hypotension for extremely preterm infants. To determine the short-term outcomes of extremely ... -
Statistical analysis plan for a pragmatic randomised controlled trial comparing enhanced acceptance and commitment therapy plus ( +) added to usual aftercare versus usual aftercare only, in patients living with or beyond cancer: SUrvivors' Rehabilitation Evaluation after CANcer (SURECAN) trial.
(BMC, 2025-01-30)BACKGROUND: The aim of the SURECAN trial is to evaluate a person-centred intervention, based on Acceptance and Commitment Therapy (ACT Plus ( +)), for people who have completed treatment for cancer with curative intent, ... -
Haemoglobin thresholds to define anaemia from age 6 months to 65 years: estimates from international data sources.
(Elsevier, 2024-02-29)BACKGROUND: Detection of anaemia is crucial for clinical medicine and public health. Current WHO anaemia definitions are based on statistical thresholds (fifth centiles) set more than 50 years ago. We sought to establish ... -
Factor V Leiden, estrogen, and multimorbidity association with venous thromboembolism in a British-South Asian cohort.
(Elsevier, 2023-10-20)Multimorbidity, estrogen use, and Factor V Leiden (FVL) are known independent risk factors for venous thromboembolism (VTE). This cross-sectional analysis of women in the Genes & Health British-South Asian cohort (N 20,048) ... -
COVID-19 serological survey using micro blood sampling.
(Springer Nature, 2021-05-04)During August 2020, we carried out a serological survey among students and employees at the Okinawa Institute of Science and Technology Graduate University (OIST), Japan, testing for the presence of antibodies against ... -
Mechanistic insights into the activation of the IKK kinase complex by the Kaposi's sarcoma herpes virus oncoprotein vFLIP.
(Elsevier, 2022-05-04)Constitutive activation of the canonical NF-κB signaling pathway is a major factor in Kaposi's sarcoma-associated herpes virus pathogenesis where it is essential for the survival of primary effusion lymphoma. Central to ... -
Human immune and gut microbial parameters associated with inter-individual variations in COVID-19 mRNA vaccine-induced immunity.
(Springer Nature, 2023-04-20)COVID-19 mRNA vaccines induce protective adaptive immunity against SARS-CoV-2 in most individuals, but there is wide variation in levels of vaccine-induced antibody and T-cell responses. However, the mechanisms underlying ... -
Altered pre-existing SARS-CoV-2-specific T cell responses in elderly individuals.
(Elsevier, 2021-12-23)Pre-existing SARS-CoV-2-specific T cells, but not antibodies, have been detected in some unexposed individuals. This may account for some of the diversity in clinical outcomes ranging from asymptomatic infection to severe ... -
Advancing health and fostering community involvement in medical research through the Genes & Health study.
(Elsevier, 2024-11-27)The Genes & Health study, an initiative focused on British-Pakistani and British-Bangladeshi volunteers, is at the forefront of diversifying genetic research and driving scientific innovation. Here, we explore how this ... -
Genetic mapping across autoimmune diseases reveals shared associations and mechanisms.
(Springer Nature, 2024-05-13)Autoimmune and inflammatory diseases are polygenic disorders of the immune system. Many genomic loci harbor risk alleles for several diseases, but the limited resolution of genetic mapping prevents determining whether the ... -
The PRIMED Consortium: Reducing disparities in polygenic risk assessment.
(Elsevier, 2024-11-18)By improving disease risk prediction, polygenic risk scores (PRSs) could have a significant impact on health promotion and disease prevention. Due to the historical oversampling of populations with European ancestry for ... -
Investigating misclassification of type 1 diabetes in a population-based cohort of British Pakistanis and Bangladeshis using polygenic risk scores.
(Springer Nature, 2025-01-13)Correct classification of type 1 (T1D) and type 2 diabetes (T2D) is challenging due to overlapping clinical features and the increasingly early onset of T2D, particularly in South Asians. Polygenic risk scores (PRSs) for ... -
Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies.
(Elsevier, 2025-01-14)In a genome-wide association study (GWAS) meta-analysis of 688,808 individuals with major depression (MD) and 4,364,225 controls from 29 countries across diverse and admixed ancestries, we identify 697 associations at 635 ... -
Consensus outcomes between health professionals and parents for oral corticosteroids in treating preschool wheeze: a multi-national survey and nominal group technique study.
(BMJ Publishing Group, 2025-01-15)OBJECTIVE: To obtain priority consensus for outcome measures of oral corticosteroid treatment of preschool wheeze that represent stakeholder groups. DESIGN: (1) A systematic review to identify a set of outcome measures; ... -
Damp and mouldy home: impact on lung health in childhood.
(BMJ Publishing Group, 2025-01-15)Within every paediatric respiratory and general paediatric clinic there will be a number of children and families who are exposed to sub-standard environments within their homes. This may be impacting on their health and ...
