Blizard Institute: Recent submissions
Now showing items 1-20 of 4806
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Emotional challenges in our work with laboratory animals: tools that support caring for others and yourself
(2021-04-01)Inevitably, most of us who work with laboratory animals will sometimes form bonds with the animals we are caring for. These relationships will positively enhance the care and wellbeing of the animals' but they also pose ... -
Co-option of endogenous retroviruses through genetic escape from TRIM28 repression
(Elsevier BV, 2023-06) -
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries.
(2023-04-20)BACKGROUND: Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. METHODS: ... -
Barriers and facilitators to HIV pre-exposure prophylaxis for cisgender and transgender women in the UK.
(2023-06-01)Uptake of oral HIV pre-exposure prophylaxis (PrEP) among cisgender and transgender women in the UK has been low. In this Review, we explore the barriers and facilitators to PrEP access for these groups, with a focus on ... -
The role of Raptor in lymphocytes differentiation and function.
(2023)Raptor, a key component of mTORC1, is required for recruiting substrates to mTORC1 and contributing to its subcellular localization. Raptor has a highly conserved N-terminus domain and seven WD40 repeats, which interact ... -
Air pollution and respiratory inequality: Lessons from high-income countries
(2023-01-01)Within urban areas in HICs, zones of increased air pollution occur along heavily used roads. As high-pollution zones are more likely to be located in the most-deprived neighbourhoods, and people living in these neighbourhoods ... -
Defining the in vivo mechanism of air pollutant toxicity using murine stress response biomarkers.
(2023-05-15)Air pollution can cause a wide range of serious human diseases. For the informed instigation of interventions which prevent these outcomes there is an urgent need to develop robust in vivo biomarkers which provide insights ... -
Teaching Neuro Images: Nonfluent variant primary progressive aphasia: A distinctive clinico-Anatomical syndrome
(2023-04-18)A 66-year-old woman presented with 4 years of progressive speech difficulty. She had nonfluent speech with phonemic errors but intact single-word comprehension and object knowledge. Her grammar was impaired in both speech ... -
Utility of novel viral and immune markers in predicting HBV treatment endpoints: A systematic review of treatment discontinuation studies.
(2023-06)BACKGROUND & AIMS: Antivirals represent the mainstay of chronic hepatitis B treatment given their efficacy and tolerability, but rates of functional cure remain low during long-term therapy. Treatment discontinuation has ... -
Rare variant contribution to cholestatic liver disease in a South Asian population in the United Kingdom.
(2023-05-19)This study assessed the contribution of five genes previously known to be involved in cholestatic liver disease in British Bangladeshi and Pakistani people. Five genes (ABCB4, ABCB11, ATP8B1, NR1H4, TJP2) were interrogated ... -
Comprehension of acoustically degraded speech in Alzheimer's disease and primary progressive aphasia.
(2023-05-15)Successful communication in daily life depends on accurate decoding of speech signals that are acoustically degraded by challenging listening conditions. This process presents the brain with a demanding computational task ... -
ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK.
(2023-05-17)PURPOSE: Genetic studies of multiple sclerosis (MS) susceptibility and severity have focused on populations of European ancestry. Studying MS genetics in other ancestral groups is necessary to determine the generalisability ... -
Qualitative study of experience of acceptance and commitment therapy (ACT+) amongst Survivors' Rehabilitation Evaluation after Cancer (SURECAN) trial participants and therapists: A protocol.
(2023-05-12)<h4>Background: </h4> This interview study forms part of a mixed methods process evaluation of the Survivors’ Rehabilitation Evaluation after Cancer (SURECAN) trial to understand the experiences of participants (who are ... -
Assessment of Platelet Function by High-Throughput Screening Light Transmission Aggregometry: Optimul Assay.
(2023)Platelet function testing is critical in the diagnosis of bleeding disorders and allows monitoring of antiplatelet therapy. The gold standard assay, light transmission aggregometry (LTA), was developed 60 years ago and ...
