Browsing Blizard Institute by Issue Date
Now showing items 1-20 of 5388
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Early versus delayed weight-bearing following operatively treated ankle fracture (WAX). A randomised controlled trial and health economic evaluation
(Elsevier, 04-06-2024)Background After surgery for a broken ankle, patients are usually instructed to avoid walking for 6 weeks (delayed weight-bearing). Walking 2 weeks after surgery (early weight-bearing) might be a safe and preferable ... -
Research priorities for the management of major trauma: an international priority setting partnership with the James Lind Alliance
(BMJ Publishing Group, 15-05-2024)Objective The objective of this study is to determine research priorities for the management of major trauma, representing the shared priorities of patients, their families, carers and healthcare professionals. Design/setting ... -
Research priorities for the management of major trauma: an international priority setting partnership with the James Lind Alliance
(BMJ Publishing Group, 15-05-2024)Objective The objective of this study is to determine research priorities for the management of major trauma, representing the shared priorities of patients, their families, carers and healthcare professionals. Design/setting ... -
Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and impacts clinical response
(American Society for Clinical Investigation, 17-06-2024)Ectopic lymphoid structures (ELSs) in the rheumatoid synovial joints sustain autoreactivity against locally expressed autoantigens. We recently identified recombinant monoclonal antibodies (RA-rmAbs) derived from single, ... -
Every minute counts: a comparison of thawing times and haemostatic quality of plasma thawed at 37 o C and 45 o C using four different methods
(Wiley, 23-06-2024)Background Having faster plasma thawing devices could be beneficial for transfusion services, as it may improve the rapid availability of thawed plasma for bleeding patients, and it might remove the need to have extended ... -
A pilot study of the role of social capital in a Parkinson’s disease risk cohort: feasibility of a web application to enable online social interactions
(JMIR Publications, 24-05-2024)Background: There is evidence that social interaction has an inverse association with the development of neurodegenerative diseases. PREDICT-Parkinson Disease (PREDICT-PD) is an online UK cohort study that stratifies ... -
Perinatal thymic-derived CD8alphabeta-expressing gammadelta T cells are innate interferon-gamma producers that expand in IL-7R/STAT5B-driven neoplasms
(Nature Research, 27-05-2024)The contribution of γδ T cells to immune responses is associated with rapid secretion of interferon-γ (IFN-γ). Here, we show a perinatal thymic wave of innate IFN-γ-producing γδ T cells that express CD8αβ heterodimers and ... -
LEVODOPA DEPENDENCE - A CASE-REPORT
(1984) -
Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism
(Wiley, 1986)MDL 72222, the selective 5-hydroxytryptamine (5-HT) M-receptor antagonist, prevented or reduced cisplatin-induced emesis in ferrets. It is suggested that cisplatin-induced, and possibly other cytotoxic drug-induced vomiting ... -
Evidence that 5-hydroxytryptamine3 receptors mediate cytotoxic drug and radiation-evoked emesis
(Macmillan Press, 1987)The involvement of 5-hydroxytryptamine (5-HT) 5-HT3 receptors in the mechanisms of severe emesis evoked by cytotoxic drugs or by total body irradiation have been studied in ferrets. Anti-emetic compounds tested were ... -
The anti-emetic potential of the 5-hydroxytryptamine3 receptor antagonist BRL 43694.
(1988-11)In ferrets, the selective 5-hydroxytryptamine (5-HT) 5-HT3 receptor antagonist BRL 43694 given as a single injection (0.05-0.5 mg kg-1 i.v.) before cisplatin, or by divided dose (2 x 0.005-2 x 0.5 mg kg-1 i.v.) before and ... -
ON THE SUBJECTIVITY OF PSYCHIATRIC-DIAGNOSIS
(1989-03)