Browsing Blizard Institute by Issue Date
Now showing items 1-20 of 5562
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Effectiveness of behavior change in rehabilitation interventions to improve functional recovery after lower limb fracture: a systematic review.
(Springer, 02-07-2024)Ankle fractures are common injuries that can significantly impact mobility and quality of life. Rehabilitation following ankle fracture treatment is crucial for recovery, yet adherence to regimens remains a challenge. ... -
Patient experiences and desires for recovery after ankle fracture surgery
(Elsevier, 02-08-2024)Objective This study investigates patients’ experiences of commencing weight-bearing after ankle fracture surgery and their recovery priorities to inform a new rehabilitation intervention. Methods Embedded within the ... -
Early versus delayed weight-bearing following operatively treated ankle fracture (WAX). A randomised controlled trial and health economic evaluation
(Elsevier, 04-06-2024)Background After surgery for a broken ankle, patients are usually instructed to avoid walking for 6 weeks (delayed weight-bearing). Walking 2 weeks after surgery (early weight-bearing) might be a safe and preferable ... -
The circulating methylome in childhood-onset inflammatory bowel disease
(Oxford University Press, 04-10-2024)The genetic contribution to inflammatory bowel disease (IBD) encompassing both Crohn’s disease (CD) and ulcerative colitis (UC), accounts for around 20% of disease variance, highlighting the need to characterise environmental ... -
Understanding the benefits of Universal Plasma and cryoprecipitate in hospitals in England
(Wiley, 04-10-2024)Background Group AB plasma does not contain anti-A or anti-B antibodies and is therefore considered universal but is in limited supply (4% of the population). There is currently no licensed universal plasma available, and ... -
Transobturator-cable-fixation in pelvic ring injuries with symphyseal disruption – A last resort?
(Springer, 07-08-2024)Purpose The role of transobturator-cable-fixation (TOCF) in traumatic symphyseal rupture of the pelvic ring remains unclear. This case series aims to evaluate TOCF in complex and revision cases in pelvic surgery. Methods A ... -
Delocalized quinolinium-macrocyclic peptides, an atypical chemotype for CNS penetration
(American Association for the Advancement of Science, 10-07-2024)Macrocyclic drugs can address an increasing range of molecular targets but enabling central nervous system (CNS) access to these drugs has been viewed as an intractable problem. We designed and synthesized a series of ... -
Pre-hospital Partial REBOA for injured patients with exsanguinating sub-diaphragmatic hemorrhage: P-PRO Study
(American Medical Association, 10-07-2024)Importance Hemorrhage is the most common cause of preventable death after injury. Most deaths occur early, in the prehospital phase of care. Objective To establish whether prehospital zone 1 (supraceliac) partial ... -
Protocol for a feasibility randomised controlled trial of the ‘Outdoor’ mobility intervention for older adults after hip fracture
(Public Library of Science, 12-08-2024)Background A high proportion of patients do not regain outdoor mobility after hip fracture. Rehabilitation explicitly targeting outdoor mobility is needed to enable these older adults to recover activities which they value ... -
Research priorities for the management of major trauma: an international priority setting partnership with the James Lind Alliance
(BMJ Publishing Group, 15-05-2024)Objective The objective of this study is to determine research priorities for the management of major trauma, representing the shared priorities of patients, their families, carers and healthcare professionals. Design/setting ... -
Research priorities for the management of major trauma: an international priority setting partnership with the James Lind Alliance
(BMJ Publishing Group, 15-05-2024)Objective The objective of this study is to determine research priorities for the management of major trauma, representing the shared priorities of patients, their families, carers and healthcare professionals. Design/setting ... -
Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and impacts clinical response
(American Society for Clinical Investigation, 17-06-2024)Ectopic lymphoid structures (ELSs) in the rheumatoid synovial joints sustain autoreactivity against locally expressed autoantigens. We recently identified recombinant monoclonal antibodies (RA-rmAbs) derived from single, ... -
Multi-parameter phenotyping of platelets and characterisation of the effects of agonists using machine learning
(Elsevier, 22-07-2024)Platelet function is driven by the expression of specialised surface markers. The concept of distinct circulating sub-populations of platelets has emerged in recent years, but their exact nature remains debatable. Objective To ... -
Every minute counts: a comparison of thawing times and haemostatic quality of plasma thawed at 37 o C and 45 o C using four different methods
(Wiley, 23-06-2024)Background Having faster plasma thawing devices could be beneficial for transfusion services, as it may improve the rapid availability of thawed plasma for bleeding patients, and it might remove the need to have extended ... -
A pilot study of the role of social capital in a Parkinson’s disease risk cohort: feasibility of a web application to enable online social interactions
(JMIR Publications, 24-05-2024)Background: There is evidence that social interaction has an inverse association with the development of neurodegenerative diseases. PREDICT-Parkinson Disease (PREDICT-PD) is an online UK cohort study that stratifies ... -
Perinatal thymic-derived CD8alphabeta-expressing gammadelta T cells are innate interferon-gamma producers that expand in IL-7R/STAT5B-driven neoplasms
(Nature Research, 27-05-2024)The contribution of γδ T cells to immune responses is associated with rapid secretion of interferon-γ (IFN-γ). Here, we show a perinatal thymic wave of innate IFN-γ-producing γδ T cells that express CD8αβ heterodimers and ... -
LEVODOPA DEPENDENCE - A CASE-REPORT
(1984) -
Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism
(Wiley, 1986)MDL 72222, the selective 5-hydroxytryptamine (5-HT) M-receptor antagonist, prevented or reduced cisplatin-induced emesis in ferrets. It is suggested that cisplatin-induced, and possibly other cytotoxic drug-induced vomiting ...
