Centre for Cell Biology and Cutaneous Research
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The Centre for Cell Biology and Cutaneous Research is a collaborative environment for working on keratinocyte and epithelial biology. Key strengths include development of skin three-dimensional models, cancer biology and genetics, extracellular matrix biology, epithelial signalling and gene discovery in genetic skin and related diseases.
Recent Submissions
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Replicating Dynamic Immune Responses at Single-Cell Resolution within a Microfluidic Human Skin Equivalent.
(Wiley, 2025-01-21)To enable in vitro investigation of human skin immunology, this study develops a microfluidic human skin equivalent (HSE) that supports the delivery of circulating immune cells via a vascular microchannel embedded within ... -
A cross-sectional study of erythromelalgia in patients with pachyonychia congenita.
(Oxford University Press, 2024-04-08) -
Upregulation of keratin 15 is required for varicella-zoster virus replication in keratinocytes and is attenuated in the live attenuated vOka vaccine strain.
(BMC, 2024-10-09)Varicella-zoster virus (VZV) is the etiological agent of chickenpox and shingles, diseases characterised by epidermal virus replication in skin and mucosa and the formation of blisters. We have previously shown that VZV ... -
A prenatal skin atlas reveals immune regulation of human skin morphogenesis.
(Springer Nature, 2024-10-16)Human prenatal skin is populated by innate immune cells, including macrophages, but whether they act solely in immunity or have additional functions in morphogenesis is unclear. Here we assembled a comprehensive multi-omics ... -
Scabies Infestations.
(American Medical Association (AMA), 2025-01-15) -
SenPred: a single-cell RNA sequencing-based machine learning pipeline to classify deeply senescent dermal fibroblast cells for the detection of an in vivo senescent cell burden.
(BMC, 2025-01-14)BACKGROUND: Senescence classification is an acknowledged challenge within the field, as markers are cell-type and context dependent. Currently, multiple morphological and immunofluorescence markers are required. However, ... -
233 A novel ex vivo skin culture device enables clinically representative skin testing
(Elsevier, 2022-12)