Centre for Cell Biology and Cutaneous Research
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The Centre for Cell Biology and Cutaneous Research is a collaborative environment for working on keratinocyte and epithelial biology. Key strengths include development of skin three-dimensional models, cancer biology and genetics, extracellular matrix biology, epithelial signalling and gene discovery in genetic skin and related diseases.
Recent Submissions
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An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo.
(Springer Nature, 2024-07-02)BACKGROUND: Restraining or slowing ageing hallmarks at the cellular level have been proposed as a route to increased organismal lifespan and healthspan. Consequently, there is great interest in anti-ageing drug discovery. ... -
Pachyonychia congenita - pathogenesis of pain and approaches to treatment.
(Oxford University Press, 2024-05-28)Pachyonychia congenita is an autosomal dominant genodermatosis characterized by a triad of chronic severe plantar pain, focal palmoplantar keratoderma, and hypertrophic nail dystrophy. Plantar pain can be debilitating and ... -
P33 Skinvaders: gamification of the skin barrier to engage school-age children in the biology of the skin
(Oxford University Press, 2024-05-17) -
Loss of Function Filaggrin Mutations are Associated with Reduced History of Acne Vulgaris in a Cohort of Bangladeshi Atopic Eczema Patients in East London.
(Oxford University Press, 2024-05-15)Acne vulgaris (AV) is the eighth most common non-fatal disease globally. Previous work identified an association between AV and increased Filaggrin (FLG) expression in the follicular epidermis, but further work did not ... -
RNA sequencing and lipidomics uncovers novel pathomechanisms in recessive X-linked ichthyosis
(Frontiers Media, 2023-06-07)Recessive X-linked ichthyosis (RXLI), a genetic disorder caused by deletion or point mutations of the steroid sulfatase (STS) gene, is the second most common form of ichthyosis. It is a disorder of keratinocyte cholesterol ... -
Molecular Modeling Studies to Probe the Binding Hypothesis of Novel Lead Compounds against Multidrug Resistance Protein ABCB1.
(2024-01-16)The expression of drug efflux pump ABCB1/P-glycoprotein (P-gp), a transmembrane protein belonging to the ATP-binding cassette superfamily, is a leading cause of multidrug resistance (MDR). We previously curated a dataset ... -
Structural basis for the modulation of MRP2 activity by phosphorylation and drugs.
(2024-03-04)Multidrug resistance-associated protein 2 (MRP2/ABCC2) is a polyspecific efflux transporter of organic anions expressed in hepatocyte canalicular membranes. MRP2 dysfunction, in Dubin-Johnson syndrome or by off-target ... -
Why are squamous cancers so aggressive in recessive dystrophic epidermolysis bullosa? Can we find new therapeutic approaches?
(Oxford University Press, 2023-10-13) -
Pachyonychia Congenita: A Research Agenda Leading to New Therapeutic Approaches.
(2023-12-14)Pachyonychia congenita (PC) is a dominantly inherited genetic disorder of cornification. PC stands out among other genodermatoses because despite its rarity, it has been the focus of a very large number of pioneering ... -
COACT: Coronary artery centerline tracker.
(Wiley, 2023-12-07)BACKGROUND: The curved planar reformation (CPR) technique is one of the most commonly used methods in clinical practice to locate coronary arteries in medical images. PURPOSE: The artery centerline is the cornerstone for ...