RSS 1.0Centre for Neuroscience, Surgery and Trauma
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Human studies of anorectal sensory function.
(Sage Publications, 2018-06-20)This review addresses three main questions: (1) Why is anorectal sensory function important in humans? (2) What is the evidence for anorectal sensory dysfunction in disease? (3) Can anorectal sensory function be modified ... -
An international multicentre prospective audit of elective rectal cancer surgery; operative approach versus outcome, including transanal total mesorectal excision (TaTME)
(John Wiley & Sons, Inc., 2018-09-25)Colorectal Disease © 2018 The Association of Coloproctology of Great Britain and Ireland Introduction: Transanal total mesorectal excision (TaTME) has rapidly emerged as a novel approach for rectal cancer surgery. Safety ... -
Safety of primary anastomosis following emergency left sided colorectal resection: an international, multi-centre prospective audit
(John Wiley & Sons, Inc., 2018-09-25)Colorectal Disease © 2018 The Association of Coloproctology of Great Britain and Ireland Introduction: Some evidence suggests that primary anastomosis following left sided colorectal resection in the emergency setting may ... -
Interventions for promoting habitual exercise in people living with and beyond cancer.
(John Wiley & Sons, Inc, 2018-09-19)BACKGROUND: This is an updated version of the original Cochrane Review published in the Cochrane Library 2013, Issue 9. Despite good evidence for the health benefits of regular exercise for people living with or beyond ... -
The impact of conversion on the risk of major complication following laparoscopic colonic surgery: an international, multicentre prospective audit.
(Wiley Online, 2018-09-25)BACKGROUND: Laparoscopy has now been implemented as a standard of care for elective colonic resection around the world. During the adoption period, studies showed that conversion may be detrimental to patients, with poorer ... -
Association of mechanical bowel preparation with oral antibiotics and anastomotic leak following left sided colorectal resection: an international, multi-centre, prospective audit.
(Wiley Online, 2018-09-25)INTRODUCTION: The optimal bowel preparation strategy to minimise the risk of anastomotic leak is yet to be determined. This study aimed to determine whether oral antibiotics combined with mechanical bowel preparation ... -
Ghrelin and Motilin Control Systems in GI Physiology and Therapeutics.
(Springer, Cham, 2016-12-30)Ghrelin and motilin are released from gastrointestinal endocrine cells during hunger, to act through G protein-coupled receptors that have closely related amino acid sequences. The actions of ghrelin are more complex than ... -
Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis
(Nature Research (part of Springer Nature), 2014-03-30)MATR3 is an RNA- and DNA-binding protein that interacts with TDP-43, a disease protein linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Using exome sequencing, we identified mutations in MATR3 ... -
Spatio-temporal motility MRI analysis of the stomach and colon.
(Wiley, 2019-02-28)BACKGROUND: MRI is increasingly used to objectively assess gastrointestinal motility. However, motility metrics often do not offer insights into the nature of contractile action. This study introduces a systematic method ... -
Normative values of regional and sub-regional gastrointestinal motility and contractility parameters using the wireless motility capsule
(Wiley, 2017-08-13)Meeting abstract 212 from NeuroGASTRO 2017 Congress, 24‐26 August 2017, Cork, Ireland -
Methods of anorectal manometry vary widely in clinical practice: Results from an international survey
(Wiley, 2017-01-18)Background: Ano‐rectal manometry (ARM) is the most commonly performed investigation for assessment of anorectal dysfunction. Its use is supported by expert consensus documents and international guidelines. Variation in ... -
Gastrointestinal motility in people with type 1 diabetes and peripheral neuropathy. Reply to Marathe CS, Rayner CK, Jones KL, et al [letter]
(Springer, Berlin, Heidelberg, 2017-09-17)Letter to the Editor -
Clinical measurement of gastrointestinal motility and function: who, when and which test?
(Nature Research, 2018-09)Symptoms related to abnormal gastrointestinal motility and function are common. Oropharyngeal and oesophageal dysphagia, heartburn, bloating, abdominal pain and alterations in bowel habits are among the most frequent reasons ... -
Delivering Trauma Mastery with an International Trauma Masters
(Elsevier, 2019-03-22)INTRODUCTION Trauma is a global problem. The goal of optimising multidisciplinary trauma care through speciality education is a challenge. No single pathway exists to educate care providers in trauma knowledge, management ... -
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
(Elsevier (Cell Press), 2018-03-21)To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant ... -
Vector manometry and LOS dynamics.
(BMJ, 2000-05-01) -
Combined Tissue-Fluid Proteomics to Unravel Phenotypic Variability in Amyotrophic Lateral Sclerosis.
(Nature Research (part of Springer Nature), 2019-03-14)The lack of biomarkers for early diagnosis, clinical stratification and to monitor treatment response has hampered the development of new therapies for amyotrophic lateral sclerosis (ALS), a clinically heterogeneous ... -
Farnesoid X Receptor - A molecular predictor of weight loss after vertical sleeve gastrectomy?
(Wiley Online, 2019-03-07)Abstract Objective To determine the expression of the bile acid receptor, farnesoid X (FXR), in human gastric mucosa and investigate correlations between expression and body-mass index (BMI) and in patients with obesity, ...
