RSS 1.0Centre for Neuroscience, Surgery and Trauma
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Neuroscience, Surgery and Trauma research at Barts and The London covers a wide range of topics: general trauma and neurotrauma, neurodegeneration, neuroimmunology, NBRC and Neurogastroenterology.
Recent Submissions
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Protocol for a feasibility randomised controlled trial of the ‘Outdoor’ mobility intervention for older adults after hip fracture
(Public Library of Science, 12-08-2024)Background A high proportion of patients do not regain outdoor mobility after hip fracture. Rehabilitation explicitly targeting outdoor mobility is needed to enable these older adults to recover activities which they value ... -
Patient experiences and desires for recovery after ankle fracture surgery
(Elsevier, 02-08-2024)Objective This study investigates patients’ experiences of commencing weight-bearing after ankle fracture surgery and their recovery priorities to inform a new rehabilitation intervention. Methods Embedded within the ... -
Need for recovery and physician well-being in emergency departments: national survey findings.
(Lippincott, Williams & Wilkins, 2021-10-01)BACKGROUND AND IMPORTANCE: Need for recovery (NFR) describes an individual's need to physically and psychologically recuperate following a period of work. Physicians working in emergency departments (EDs) have higher NFR ... -
Following hip fracture, hospital organisational factors associated with prescription of anti-osteoporosis medication on discharge, to address imminent refracture risk: a record-linkage study.
(Oxford University Press, 2024-07-11)Patients who sustain a hip fracture are known to be at imminent refracture risk. Their complex multidisciplinary rehabilitation needs to include falls prevention and anti-osteoporosis medication (AOM) to prevent such ... -
Rehabilitation after surgery for hip fracture – the impact of prompt, frequent and mobilisation-focused physiotherapy on discharge outcomes: an observational cohort study
(Springer Science and Business Media LLC, 2024-07-23)Purpose To determine the relationship between three postoperative physiotherapy activities (time to frst postoperative walk, activity on the day after surgery, and physiotherapy frequency), and the outcomes of hospital ... -
The Role of the Gut Microbiome in Neuroinflammation and Chemotherapy-Induced Peripheral Neuropathy.
(Elsevier, 2024-07-18)Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most debilitating adverse effects caused by chemotherapy drugs such as paclitaxel, oxaliplatin and vincristine. It is untreatable and often leads to the ... -
CORRECTION OF TRAUMA-INDUCED COAGULOPATHY BY GOAL DIRECTED THERAPY: A SECONDARY ANALYSIS OF THE ITACTIC TRIAL.
(2024-08-08)BACKGROUND: Trauma hemorrhage induces a coagulopathy with a high associated mortality rate. The Implementing Treatment Algorithms for the Correction of Trauma Induced Coagulopathy (ITACTIC) randomized trial tested two ... -
Prehospital Partial Resuscitative Endovascular Balloon Occlusion of the Aorta for Exsanguinating Subdiaphragmatic Hemorrhage.
(2024-07-10)IMPORTANCE: Hemorrhage is the most common cause of preventable death after injury. Most deaths occur early, in the prehospital phase of care. OBJECTIVE: To establish whether prehospital zone 1 (supraceliac) partial ... -
Transforming research to improve therapies for trauma in the twenty-first century.
(2024-02-13)Improvements have been made in optimizing initial care of trauma patients, both in prehospital systems as well as in the emergency department, and these have also favorably affected longer term outcomes. However, as specific ... -
Descriptive study of perineuronal net in enteric nervous system of humans and mice.
(Wiley, 2024-07-06)Perineuronal nets (PNN) are highly specialized structures of the extracellular matrix around specific groups of neurons in the central nervous system (CNS). They play functions related to optimizing physiological processes ... -
The association of bariatric surgery and carpal tunnel syndrome : a propensity score-matched cohort study
Objectives To test the hypothesis that weight loss following bariatric surgery is associated with a reduced risk of developing carpal tunnel syndrome (CTS) when compared to obese patients who do not undergo bariatric ... -
The human colon: Evidence for degenerative changes during aging and the physiological consequences.
(Wiley, 2024-06-17)BACKGROUND: The incidence of constipation increases among the elderly (>65 years), while abdominal pain decreases. Causes include changes in lifestyle (e.g., diet and reduced exercise), disease and medications affecting ... -
Effectiveness of behavior change in rehabilitation interventions to improve functional recovery after lower limb fracture: a systematic review.
(Springer, 02-07-2024)Ankle fractures are common injuries that can significantly impact mobility and quality of life. Rehabilitation following ankle fracture treatment is crucial for recovery, yet adherence to regimens remains a challenge. ...
