Centre for Tumour Biology: Recent submissions
Now showing items 121-140 of 380
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Multicentre derivation and validation of a colitis-associated colorectal cancer risk prediction web tool.
(BMJ, 2021-05-14)OBJECTIVE: Patients with ulcerative colitis (UC) diagnosed with low-grade dysplasia (LGD) have increased risk of developing advanced neoplasia (AN: high-grade dysplasia or colorectal cancer). We aimed to develop and validate ... -
The role of single-cell sequencing in studying tumour evolution.
(2021-05-26)Tumour evolution is a complex interplay between the acquisition of somatic (epi)genomic changes in tumour cells and the phenotypic consequences they cause, all in the context of a changing microenvironment. Single-cell ... -
LiquidCNA: Tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterations.
(2021-08-20)Cell-free DNA (cfDNA) measured via liquid biopsies provides a way for minimally invasive monitoring of tumor evolutionary dynamics during therapy. Here we present liquidCNA, a method to track subclonal evolution from ... -
Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns
(2021-08)Central to tumor evolution is the generation of genetic diversity. However, the extent and patterns by which de novo karyotype alterations emerge and propagate within human tumors are not well understood, especially at ... -
Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in Covid-19.
(2021-07-09)Rationale: Resolution mechanisms are central in both the maintenance of homeostasis and the return to catabasis following tissue injury and/or infections. Amongst the pro-resolving mediators, the essential fatty acid-derived ... -
Predicting Colorectal Cancer Occurrence in IBD.
(MDPI, 2021-06-10)Patients with colonic inflammatory bowel disease (IBD) are at an increased risk of developing colorectal cancer (CRC), and are therefore enrolled into a surveillance programme aimed at detecting dysplasia or early cancer. ... -
Integrated OMICs unveil the bone-marrow microenvironment in human leukemia.
(Cell Press, 2021-05-11)The bone-marrow (BM) niche is the spatial environment composed by a network of multiple stromal components regulating adult hematopoiesis. We use multi-omics and computational tools to analyze multiple BM environmental ... -
Endothelial Jagged1 promotes solid tumor growth through both pro-angiogenic and angiocrine functions
(Impact Journals, LLC, 2015-06-08)Angiogenesis is an essential process required for tumor growth and progression. The Notch signaling pathway has been identified as a key regulator of the neo-angiogenic process. Jagged-1 (Jag1) is a Notch ligand required ... -
Hallmarks of cancer-the new testament.
(Royal Society Publishing, 2021-01-20)Diagnosis and treatment of disease demand a sound understanding of the underlying mechanisms, determining any Achilles' heel that can be targeted in effective therapies. Throughout history, this endeavour to decipher the ... -
Unconventional role of RAC1 in MET-driven anchorage-independent tumor growth.
(2020-08-18)We reported that RAC1 is a master regulator of cell migration and anchorage-independent growth, downstream of the oncogenic Receptor Tyrosine Kinase (RTK) MET. RAC1 growth-promoting role is guanosine triphosphatase (GTPase)- ... -
Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches.
(2016-01-27)Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modeling, mass spectrometry-based quantitation of network ... -
ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy.
(2019-03)Typical Martsolf syndrome is characterized by congenital cataracts, postnatal microcephaly, developmental delay, hypotonia, short stature and biallelic hypomorphic mutations in either RAB3GAP1 or RAB3GAP2. Genetic analysis ... -
Heartburn Sensation in Non-Erosive Reflux Disease: Pattern of Superficial Sensory Nerves Expressing TRPV1 and Epithelial Cells Expressing ASIC3 Receptors.
(2021-03-03)The underlying causes of heartburn, characteristic symptom of gastro-esophageal reflux disease(GERD), remain incompletely understood. Superficial afferent innervation of the esophageal mucosa in nonerosive reflux disease(NERD) ... -
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
(2021-02-08)In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant ... -
3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer
(American Association for Cancer Research (AACR), 2021-02-15) -
The MOBSTER R package for tumour subclonal deconvolution from bulk DNA whole-genome sequencing data
(BioMed Central, 2020-11-17)