Unconventional role of RAC1 in MET-driven anchorage-independent tumor growth.
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Embargoed until: 5555-01-01
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Embargoed until: 5555-01-01
Reason: Version not permitted.
Volume
7
Pagination
1803029 - ?
DOI
10.1080/23723556.2020.1803029
Journal
Mol Cell Oncol
Issue
ISSN
2372-3556
Metadata
Show full item recordAbstract
We reported that RAC1 is a master regulator of cell migration and anchorage-independent growth, downstream of the oncogenic Receptor Tyrosine Kinase (RTK) MET. RAC1 growth-promoting role is guanosine triphosphatase (GTPase)- and phosphatidylinositol 3-kinase (PI3K)-independent but promotes mammalian target of rapamycin (mTOR) signaling through triggering its plasma membrane localization.