Browsing Centre for Tumour Biology by Title

The 2019 Mathematical Oncology Roadmap.

Rockne, RC; Hawkins-Daarud, A; Swanson, KR; Sluka, JP; Glazier, JA; Macklin, P; Hormuth, D; Jarrett, AM; Lima, EABDF; Oden, J (IOP Publishing, 2019-04-16)

Whether the nom de guerre is Mathematical Oncology, Computational or Systems Biology, Theoretical Biology, Evolutionary Oncology, Bioinformatics, or simply Basic Science, there is no denying that mathematics continues to ...

3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer

Peck, B; Bland, P; Mavrommati, I; Muirhead, G; Cottom, H; Wai, PT; Maguire, SL; Barker, HE; Morrison, E; Kriplani, D (American Association for Cancer Research (AACR), 2021-02-15)

3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

Jones, DT; Valli, A; Haider, S; Zhang, Q; Smethurst, EA; Schug, ZT; Peck, B; Aboagye, EO; Critchlow, SE; Schulze, A (2019-02)

A 3D in vitro model of the human breast duct: a method to unravel myoepithelial-luminal interactions in the progression of breast cancer

Carter, EP; Gopsill, JA; Gomm, JJ; Jones, JL; Grose, RP (2017-04-21)

A 3d In Vitro Model To Unravel Myoepithelial-Macrophage Interactions In Breast Cancer Progression

Roozitalab, R; Allen, M; Grose, RP (2022)

450 CLONAL DYNAMICS AND CELL-OF-ORIGIN OF NORMAL HEPATOCYTE EXPANSIONS IN HOMEOSTATIC HUMAN LIVERS AND THEIR ASSOCIATION WITH THE BILIARY EPITHELIUM

Passman, AM; Haughey, MJ; Carlotti, E; Williams, M; Cereser, B; Russo, FP; Hoare, M; Kocher, H; Chin-Aleong, J; Graham, TA (Elsevier, 2020-05-01)

6: Development of non-invasive imaging of integrin alpha-v-beta-6 (αvβ6)-positive lung cancers in advance of testing αvβ6-targeted therapies

Rudran, B; Desai, A; Luzarraga, M; Hodivala-Dilke, K; Foster, J; Sosabowski, J; Marshall, J (Elsevier, 2017-01)

700PSTAR-PAC: Phase I clinical trial repurposing all trans retinoic acid (ATRA) as stromal targeting agent in a novel drug combination for pancreatic cancer

Kocher, HM; Basu, B; Froeling, FEM; Sarker, D; Slater, S; Carlin, D; Coetzee, C; de Souza, N; Goulart, M; Hughes, C (2019-10-01)

A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma

Haider, S; Wang, J; Nagano, A; Desai, A; Arumugam, P; Dumartin, L; Fitzgibbon, J; Hagemann, T; Marshall, JF; Kocher, HM (2014)

Improved usage of the repertoires of pancreatic ductal adenocarcinoma (PDAC) profiles is crucially needed to guide the development of predictive and prognostic tools that could inform the selection of treatment options.

A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma.

Haider, S; Wang, J; Nagano, A; Desai, A; Arumugam, P; Dumartin, L; Fitzgibbon, J; Hagemann, T; Marshall, JF; Kocher, HM (2014)

Improved usage of the repertoires of pancreatic ductal adenocarcinoma (PDAC) profiles is crucially needed to guide the development of predictive and prognostic tools that could inform the selection of treatment options.

Abstract 4576: 3D in vitro models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancer

Joy, JD; Malacrida, B; Laforêts, F; Kotantaki, P; Maniati, E; Hopkins, S; Garrobo-Calleja, I; Gautrot, J; Balkwill, F (American Association for Cancer Research (AACR), 2023-04-04)

Abstract 958: Effective targeting of pancreatic ductal adenocarcinoma metastases with an integrin αvβ6-targeting peptide-drug conjugate

Murray, ER; Brown, NF; Howard, P; Masterson, L; Zammarchi, F; van Berkel, PH; Marshall, JF (American Association for Cancer Research (AACR), 2021-07-01)

ADAM12 is a circulating marker for stromal activation in pancreatic cancer and predicts response to chemotherapy

Veenstra, VL; Damhofer, H; Waasdorp, C; van Rijssen, LB; van de Vijver, MJ; Dijk, F; Wilmink, HW; Besselink, MG; Busch, OR; Chang, DK (2018-11-16)

ADORA2A-mediated protection of ischemia-reperfusion injury. Role of protein kinase N1: A new player in the pathophysiology of experimental stroke

Zur Nedden, S; Orset, C; Haellewyn, B; Freret, T; Fresser, F; Eith, R; Cameron, AJM; Parker, PJ; Baier, G; Baier-Bitterlich, G (2018-12)

Age-associated mitochondrial DNA mutations cause metabolic remodelling that contributes to accelerated intestinal tumorigenesis.

Smith, AL; Whitehall, JC; Bradshaw, C; Gay, D; Robertson, F; Blain, AP; Hudson, G; Pyle, A; Houghton, D; Hunt, M (2020-10)

Oxidative phosphorylation (OXPHOS) defects caused by somatic mitochondrial DNA (mtDNA) mutations increase with age in human colorectal epithelium and are prevalent in colorectal tumours, but whether they actively contribute ...

alpha v beta 3 Integrin and tumour blood vessels - learning from the past to shape the future

Demircioglu, F; Hodivala-Dilke, K (2016-10)

Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance.

Therizols, G; Bash-Imam, Z; Panthu, B; Machon, C; Vincent, A; Ripoll, J; Nait-Slimane, S; Chalabi-Dchar, M; Gaucherot, A; Garcia, M (2022-01-10)

Mechanisms of drug-tolerance remain poorly understood and have been linked to genomic but also to non-genomic processes. 5-fluorouracil (5-FU), the most widely used chemotherapy in oncology is associated with resistance. ...

Analysis of clonal expansions through the normal and premalignant human breast epithelium reveals the presence of luminal stem cells

Cereser, B; Jansen, M; Austin, E; Elia, G; McFarlane, T; van Deurzen, CHM; Sieuwerts, AM; Daidone, MG; Tadrous, PJ; Wright, NA (2018-01)

Antagonism between FOXO and MYC Regulates Cellular Powerhouse.

Peck, B; Ferber, EC; Schulze, A (Frontiers Media SA, 2013-04-25)

Alterations in cellular metabolism are a key feature of the transformed phenotype. Enhanced macromolecule synthesis is a prerequisite for rapid proliferation but may also contribute to induction of angiogenesis, metastasis ...

Author Correction: Metastatic-niche labelling reveals parenchymal cells with stem features (vol 572, pg 603, 2019)

Ombrato, L; Nolan, E; Kurelac, I; Mavousian, A; Bridgeman, VL; Heinze, I; Chakravarty, P; Horswell, S; Gonzalez-Gualda, E; Matacchione, G (2019-11-28)

Correction to: Nature https://doi.org/10.1038/s41586-019-1487-6Published online 28 August 2019.