Browsing Centre for Tumour Biology by Title

124P Acquired resistance to first-line chemo- and EGFRab-therapy in mCRC: Biopsy analysis of the iSCORE trial

Lane, R; Mencel, J; Turkes, F; Challoner, BR; McCafferty, N; Ntellas, P; Barber, LJ; Rana, I; Chen, H-C; Begum, R (Elsevier, 2024-06)

The 2019 Mathematical Oncology Roadmap.

Rockne, RC; Hawkins-Daarud, A; Swanson, KR; Sluka, JP; Glazier, JA; Macklin, P; Hormuth, D; Jarrett, AM; Lima, EABDF; Oden, J (IOP Publishing, 2019-04-16)

Whether the nom de guerre is Mathematical Oncology, Computational or Systems Biology, Theoretical Biology, Evolutionary Oncology, Bioinformatics, or simply Basic Science, there is no denying that mathematics continues to ...

30P Immunological markers of pathological and clinical and outcomes in mismatch repair deficient (MMRd) colorectal cancer (CRC)

Challoner, BR; Slater, SC; Sansano, HB; Aresu, M; Bryant, A; Chen, H-C; Begum, R; Rana, T; Zhitkov, O; Leamon, B (Elsevier, 2024-06)

3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer

Peck, B; Bland, P; Mavrommati, I; Muirhead, G; Cottom, H; Wai, PT; Maguire, SL; Barker, HE; Morrison, E; Kriplani, D (American Association for Cancer Research (AACR), 2021-02-15)

3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

Jones, DT; Valli, A; Haider, S; Zhang, Q; Smethurst, EA; Schug, ZT; Peck, B; Aboagye, EO; Critchlow, SE; Schulze, A (2019-02)

A 3D in vitro model of the human breast duct: a method to unravel myoepithelial-luminal interactions in the progression of breast cancer

Carter, EP; Gopsill, JA; Gomm, JJ; Jones, JL; Grose, RP (2017-04-21)

A 3d In Vitro Model To Unravel Myoepithelial-Macrophage Interactions In Breast Cancer Progression

Roozitalab, R; Allen, M; Grose, RP (2022)

450 CLONAL DYNAMICS AND CELL-OF-ORIGIN OF NORMAL HEPATOCYTE EXPANSIONS IN HOMEOSTATIC HUMAN LIVERS AND THEIR ASSOCIATION WITH THE BILIARY EPITHELIUM

Passman, AM; Haughey, MJ; Carlotti, E; Williams, M; Cereser, B; Russo, FP; Hoare, M; Kocher, H; Chin-Aleong, J; Graham, TA (Elsevier, 2020-05-01)

6: Development of non-invasive imaging of integrin alpha-v-beta-6 (αvβ6)-positive lung cancers in advance of testing αvβ6-targeted therapies

Rudran, B; Desai, A; Luzarraga, M; Hodivala-Dilke, K; Foster, J; Sosabowski, J; Marshall, J (Elsevier, 2017-01)

700PSTAR-PAC: Phase I clinical trial repurposing all trans retinoic acid (ATRA) as stromal targeting agent in a novel drug combination for pancreatic cancer

Kocher, HM; Basu, B; Froeling, FEM; Sarker, D; Slater, S; Carlin, D; Coetzee, C; de Souza, N; Goulart, M; Hughes, C (2019-10-01)

A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma

Haider, S; Wang, J; Nagano, A; Desai, A; Arumugam, P; Dumartin, L; Fitzgibbon, J; Hagemann, T; Marshall, JF; Kocher, HM (2014)

Improved usage of the repertoires of pancreatic ductal adenocarcinoma (PDAC) profiles is crucially needed to guide the development of predictive and prognostic tools that could inform the selection of treatment options.

A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma.

Haider, S; Wang, J; Nagano, A; Desai, A; Arumugam, P; Dumartin, L; Fitzgibbon, J; Hagemann, T; Marshall, JF; Kocher, HM (2014)

Improved usage of the repertoires of pancreatic ductal adenocarcinoma (PDAC) profiles is crucially needed to guide the development of predictive and prognostic tools that could inform the selection of treatment options.

Abstract 4576: 3D in vitro models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancer

Joy, JD; Malacrida, B; Laforêts, F; Kotantaki, P; Maniati, E; Hopkins, S; Garrobo-Calleja, I; Gautrot, J; Balkwill, F (American Association for Cancer Research (AACR), 2023-04-04)

Abstract 5591: Circulating tumor DNA for recurrence prediction and efficacy analysis in the ICONIC trial of peri-operative FLOT and avelumab (PD-L1) in localized esophago-gastric adenocarcinoma

Gerlinger, M; Gordon, A; Barber, LJ; Laliotis, G; Athauda, A; Challoner, B; Woolston, A; Mansukhani, S; Dunstan, M; Petrou, N (American Association for Cancer Research (AACR), 2023-04-04)

Abstract 5593: Clonal mutation burden and evolutionary dynamics analysis in metastatic gastro-esophageal adenocarcinoma (GEA) by error corrected whole-exome circulating tumor DNA sequencing

McCafferty, N; Fong, C; Barber, LJ; Woolston, A; Kleftogiannis, D; Rana, T; Cromarty, S; Kidd, S; Begum, R; Chau, I (American Association for Cancer Research (AACR), 2023-04-04)

Abstract 958: Effective targeting of pancreatic ductal adenocarcinoma metastases with an integrin αvβ6-targeting peptide-drug conjugate

Murray, ER; Brown, NF; Howard, P; Masterson, L; Zammarchi, F; van Berkel, PH; Marshall, JF (American Association for Cancer Research (AACR), 2021-07-01)

Abstract P6-10-05: Mutations in the RNA Splicing Factor SF3B1 drive endocrine therapy resistance and confer a targetable replication stress response defect through PARP inhibition

Bland, P; Saville, H; Read, A; Wai, P; Muirhead, G; Curnow, L; Nieminuszczy, J; Ravindran, N; John, M; Hedayat, S (American Association for Cancer Research (AACR), 2023-03-01)

ADAM12 is a circulating marker for stromal activation in pancreatic cancer and predicts response to chemotherapy

Veenstra, VL; Damhofer, H; Waasdorp, C; van Rijssen, LB; van de Vijver, MJ; Dijk, F; Wilmink, HW; Besselink, MG; Busch, OR; Chang, DK (2018-11-16)

ADORA2A-mediated protection of ischemia-reperfusion injury. Role of protein kinase N1: A new player in the pathophysiology of experimental stroke

Zur Nedden, S; Orset, C; Haellewyn, B; Freret, T; Fresser, F; Eith, R; Cameron, AJM; Parker, PJ; Baier, G; Baier-Bitterlich, G (2018-12)

Age-associated mitochondrial DNA mutations cause metabolic remodelling that contributes to accelerated intestinal tumorigenesis.

Smith, AL; Whitehall, JC; Bradshaw, C; Gay, D; Robertson, F; Blain, AP; Hudson, G; Pyle, A; Houghton, D; Hunt, M (2020-10)

Oxidative phosphorylation (OXPHOS) defects caused by somatic mitochondrial DNA (mtDNA) mutations increase with age in human colorectal epithelium and are prevalent in colorectal tumours, but whether they actively contribute ...