The role of single-cell sequencing in studying tumour evolution.
Volume
10
Pagination
49 - ?
DOI
10.12703/r/10-49
Journal
Faculty Reviews
Metadata
Show full item recordAbstract
Tumour evolution is a complex interplay between the acquisition of somatic (epi)genomic changes in tumour cells and the phenotypic consequences they cause, all in the context of a changing microenvironment. Single-cell sequencing offers a window into this dynamic process at the ultimate resolution of individual cells. In this review, we discuss the transformative insight offered by single-cell sequencing technologies for understanding tumour evolution.