Centre for Biochemical Pharmacology: Recent submissions
Now showing items 121-140 of 333
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Structural basis for a complex I mutation that blocks pathological ROS production.
(2021-01-29)Mitochondrial complex I is central to the pathological reactive oxygen species (ROS) production that underlies cardiac ischemia-reperfusion (IR) injury. ND6-P25L mice are homoplasmic for a disease-causing mtDNA point ... -
The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease.
(Elsevier, 2021-08-17)Persistent ill health after acute COVID-19-referred to as long COVID, the post-acute COVID-19 syndrome, or the post-COVID-19 condition-has emerged as a major concern. We undertook an international consensus exercise to ... -
With a grain of salt: Sodium elevation and metabolic remodelling in heart failure.
(2021-08-06)Elevated intracellular Na (Nai) and metabolic impairment are interrelated pathophysiological features of the failing heart (HF). There have been a number of studies showing that myocardial sodium elevation subtly affects ... -
Hypercholesterolemia Impairs Clearance of Neutrophil Extracellular Traps and Promotes Inflammation and Atherosclerotic Plaque Progression.
(2021-08-05)OBJECTIVE: Hypercholesterolemia-induced NETosis and accumulation of neutrophil extracellular traps (NETs) in the atherosclerotic lesion exacerbates inflammation and is causally implicated in plaque progression. We investigated ... -
Differential sensitivity of inflammatory macrophages and alternatively activated macrophages to ferroptosis.
(2021-07-17)Acumulation of oxidized membrane lipids ultimately results in ferroptotic cell death, which can be prevented by the selenoenzyme glutathione peroxidase 4 (Gpx4). In vivo conditions promoting ferroptosis and susceptible ... -
Expression of ACKR4 demarcates the "peri-marginal sinus," a specialized vascular compartment of the splenic red pulp.
(2021-07-13)The spleen comprises defined microanatomical compartments that uniquely contribute to its diverse host defense functions. Here, we identify a vascular compartment within the red pulp of the spleen delineated by expression ... -
Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses.
(Frontiers Media, 2021-06-15)Passive immunization using monoclonal antibodies will play a vital role in the fight against COVID-19. The recent emergence of viral variants with reduced sensitivity to some current antibodies and vaccines highlights the ... -
Changes in brown adipose tissue lipid mediator signatures with aging, obesity, and DHA supplementation in female mice
(Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology (FASEB)., 2021-05-07)Brown adipose tissue (BAT) dysfunction in aging and obesity has been related to chronic unresolved inflammation, which could be mediated by an impaired pro-duction of specialized proresolving lipid mediators (SPMs), such ... -
TLRs toll for Tregs.
(2019-12)Discussion on TLR3 triggering in CD4 T cells induces IFN beta and IL10-producing iTregs that suppress food allergy. -
Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component.
(EMBO Press, 2021-05-25)Pancreatic ductal adenocarcinoma (PDAC) patients frequently suffer from undetected micro-metastatic disease. This clinical situation would greatly benefit from additional investigation. Therefore, we set out to identify ... -
Post-COVID symptoms reported at asynchronous virtual review and stratified follow-up after COVID-19 pneumonia.
(Royal College of Physicians, 2021-06-08)BACKGROUND: The COVID-19 pandemic has strained healthcare systems and how best to address post-COVID health needs is uncertain. Here we describe the post-COVID symptoms of 675 patients followed up using a virtual review ... -
Expert Consensus on the Tapering of Oral Corticosteroids for the Treatment of Asthma A Delphi Study
(American Thoracic Society, 2021-04-01) -
Mesoglycan connects Syndecan-4 and VEGFR2 through Annexin A1 and formyl peptide receptors to promote angiogenesis in vitro.
(2021-05-31)Mesoglycan is a mixture of glycosaminoglycans (GAG) with fibrinolytic effects and the potential to enhance skin wound repair. Here, we have used endothelial cells isolated from Wild Type (WT) and Syndecan-4 null (Sdc4-/-) ... -
Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity
(Wiley, 2021-04-27)Extracellular vesicles (EVs) are emerging as key players in different stages of atherosclerosis. Here we provide evidence that EVs released by mixed aggregates of monocytes and platelets in response to TNF-α display ... -
Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
(Elsevier, 2021-05-01)BACKGROUND: In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. METHODS: This randomised, controlled, open-label, ... -
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial.
(Elsevier, 2021-05-14)BACKGROUND: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with ... -
Eosinophilic and non-eosinophilic asthma: an expert consensus framework to characterize phenotypes in a global real-life severe asthma cohort.
(2021-04-19)BACKGROUND: Phenotypic characteristics of eosinophilic and non-eosinophilic asthma patients are not well-characterized in global, real life severe asthma cohorts. RESEARCH QUESTION: What is the prevalence of eosinophilic ...