Centre for Biochemical Pharmacology: Recent submissions
Now showing items 101-120 of 333
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Annexin A1 Released in Extracellular Vesicles by Pancreatic Cancer Cells Activates Components of the Tumor Microenvironment, through Interaction with the Formyl-Peptide Receptors
(MDPI, 2020-12-18)Pancreatic cancer (PC) is one of the most aggressive cancers in the world. Several extracellular factors are involved in its development and metastasis to distant organs. In PC, the protein Annexin A1 (ANXA1) appears to ... -
Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A4 Mimetics (QNX-sLXms)
(American Chemical Society, 2021-06-17)Failure to resolve inflammation underlies many prevalent pathologies. Recent insights have identified lipid mediators, typified by lipoxins (LXs), as drivers of inflammation resolution, suggesting potential therapeutic ... -
Isolation of stromal vascular fraction cell suspensions from mouse and human adipose tissues for downstream applications.
(2021-06-18)This protocol outlines a reliable and versatile approach to isolate stromal vascular fraction cells from different adipose tissues across human and mouse species. A number of downstream applications can then be performed ... -
Adipose tissue dendritic cells in steady-state
(2019-03) -
CD36 pumps fat to defang killer T cells in tumors
(2021-08-03) -
Nox2-deficient Tregs improve heart transplant outcomes via their increased graft recruitment and enhanced potency.
(2021-08-10)Nox2 is a ROS-generating enzyme, deficiency of which increases suppression by Tregs in vitro and in an in vivo model of cardiac remodelling. Since Tregs have emerged as a candidate therapy in autoimmunity and transplantation, ... -
The low-density lipoprotein receptor (LDL-R) is an immune-metabolic checkpoint during CD8 T Lymphocytes activation
(2021-08-01)Meeting abstract -
Evaluation of Competing Methodologies for In Vivo Tracking of Human Regulatory T Cells Intended for Adoptive Cell Therapy in Transplantation
(2021-04-27)Meeting Abstract 792 from ASGCT Annual Meeting Abstracts -
Dysregulated plasma lipid mediator profiles in critically ill COVID-19 patients.
(Public Library of Science, 2021-08-26)Coronavirus disease (COVID)-19, as a result of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, has been the direct cause of over 2.2 million deaths worldwide. A timely coordinated host-immune response ... -
Dysregulated Maresin Concentrations in Plasma and Nasal Secretions From Patients With Chronic Rhinosinusitis
(Frontiers Media, 2021-08-31)The mechanisms that lead to disease onset and propagation in patients with chronic rhinosinusitis (CRS) are not fully elucidated. Maresins (MaR) are a family of essential fatty acid-derived lipid mediators that play a ... -
Imaging the lung: the old ways and the new
(2017-04)