Browsing Centre for Biochemical Pharmacology by Issue Date

Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects

Szabo, C; Lim, LHK; Cuzzocrea, S; Getting, SJ; Zingarelli, B; Flower, RJ; Salzman, AL; Perretti, M (1997-10-06)

Upregulation of ICAM-1 expression on J774.2 macrophages by endotoxin involves activation of NF-kappaB but not protein tyrosine kinase: comparison to induction of iNOS.

Ruetten, H; Thiemermann, C; Perretti, M (1999)

This study compares the signal transduction pathway which leads to the upregulation of intercellular adhesion molecule-1 (ICAM-1) expression with that of the increase in the expression of inducible nitric oxide synthase ...

Inhibition of established collagen-induced arthritis with a tumour necrosis factor-alpha inhibitor expressed from a self-contained doxycycline regulated plasmid

Gould, DJ; Bright, C; Chernajovsky, Y (2004)

15-epi-lipoxin A(4)-mediated induction of nitric oxide explains how aspirin inhibits acute inflammation

Paul-Clark, MJ; van Cao, T; Moradi-Bidhendi, N; Cooper, D; Gilroy, DW (2004-07-05)

Antiflammin-2 activates the human formyl-peptide receptor like 1

Kamal, AM; Hayhoe, RPG; Paramasivam, A; Cooper, D; Flower, RJ; Solito, E; Perretti, M (2006-10)

Gene therapy with an improved doxycycline-regulated plasmid encoding a tumour necrosis factor-alpha inhibitor in experimental arthritis

Gould, D; Yousaf, N; Fatah, R; Subang, MC; Chernajovsky, Y (2007)

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

Spite, M; Norling, LV; Summers, L; Yang, R; Cooper, D; Petasis, NA; Flower, RJ; Perretti, M; Serhan, CN (2009-10-29)

Modulation of experimental autoimmune encephalomyelitis by endogenous Annexin A1

Paschalidis, N; Iqbal, AJ; Maione, F; Wood, EG; Perretti, M; Flower, RJ; D'Acquisto, F (2009-11-13)

Melanocortin Control of Cell Trafficking in Vascular Inflammation

Patel, HB; Leoni, G; Melendez, TM; Sampaio, ALF; Perretti, M (2010)

Selective Inhibitors of Kv11.1 Regulate IL-6 Expression by Macrophages in Response to TLR/IL-1R Ligands

Hunter, C; Kadakia, TB; Cooper, D; Perretti, M; Schwartz, RC; Brown, SB (2010)

Human beta-defensin 3 has immunosuppressive activity in vitro and in vivo

Semple, F; Webb, S; Li, HN; Patel, HB; Perretti, M; Jackson, IJ; Gray, M; Davidson, DJ; Dorin, JR (2010-04)

Downstream Gene Activation of the Receptor ALX by the Agonist Annexin A1

Renshaw, D; Montero-Melendez, T; Dalli, J; Kamal, A; Brancaleone, V; D'Acquisto, F; Cirino, G; Perretti, M (2010-09-17)

Melanocortin receptors as novel effects of macrophage responses in inflammation

Patel, HB; Montero-Melendez, T; Greco, KV; Perretti, M (2011)

Melanocortin receptors as novel effectors of macrophage responses in inflammation.

Patel, HB; Montero-Melendez, T; Greco, KV; Perretti, M (2011)

Macrophages have crucial functions in initiating the inflammatory reaction in a strict temporal and spatial manner to provide a "clear-up" response required for resolution. Hormonal peptides such as melanocortins modulate ...

Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis

Damazo, AS; Sampaio, ALF; Nakata, CMAG; Flower, RJ; Perretti, M; Oliani, SM (2011-10-19)

T cell immunity and cardiovascular metabolic disorders: does metabolism fuel inflammation?

Mauro, C; Marelli-Berg, FM (2012)

A novel hybrid promoter responsive to pathophysiological and pharmacological regulation

Subang, MC; Fatah, R; Bright, C; Blanco, P; Berenstein, M; Wu, Y; Podhajcer, OL; Winyard, PG; Chernajovsky, Y; Gould, D (2012-04)

Up-Regulation of Annexin-A1 and Lipoxin A(4) in Individuals with Ulcerative Colitis May Promote Mucosal Homeostasis

Vong, L; Ferraz, JGP; Dufton, N; Panaccione, R; Beck, PL; Sherman, PM; Perretti, M; Wallace, JL (2012-06-18)

The impact of endogenous annexin A1 on glucocorticoid control of in ammatory arthritis

Patel, HB; Kornerup, KN; Sampaio, ALF; Acquisto, FD; Seed, MP; Girol, AP; Gray, M; Pitzalis, C; Oliani, SM; Perretti, M (2012-11)

Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides.

Ahmed, TJ; Montero-Melendez, T; Perretti, M; Pitzalis, C (2013)

The resolution of inflammation is now known to be an active process, armed with a multitude of mediators both lipid and protein in nature. Melanocortins are peptides endowed with considerable promise with their proresolution ...