Centre for Biochemical Pharmacology: Recent submissions
Now showing items 141-160 of 333
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Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs
(Frontiers Media, 2021-03-29)Neuromodulation of the immune system has been proposed as a novel therapeutic strategy for the treatment of inflammatory conditions. We recently demonstrated that stimulation of near-organ autonomic nerves to the spleen ... -
The impact of the first COVID-19 surge on severe asthma patients in the UK. Which is worse: the virus or the lockdown?
(2021-01)Asthma therapy, including monoclonal antibodies, was not associated with #COVID19 infection or hospitalisation in a UK severe asthma population. Shielding led to a reported worsening of mental health in nearly half of ... -
Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial.
(Elsevier, 2020-12-22)BACKGROUND: ANDHI was done to assess the efficacy of benralizumab, including onset of effect and impact on health-related quality of life (HRQOL), exacerbation rate, lung function, and nasal polyposis symptoms. METHODS: ... -
Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction.
(2021-02-02)Tyro3, AXL, and MerTK (TAM) receptors are activated in macrophages in response to tissue injury and as such have been proposed as therapeutic targets to promote inflammation resolution during sterile wound healing, including ... -
Delayed-onset myocarditis following COVID-19.
(Elsevier, 2021-02-19) -
Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era.
(BMJ, 2020-12-09)BACKGROUND: The UK Severe Asthma Registry (UKSAR) is the world's largest national severe asthma registry collecting standardised data on referrals to UK specialist services. Novel biologic therapies have transformed the ... -
Factors associated with frequent exacerbations in the UK Severe Asthma Registry.
(Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology, 2021-01-15)BACKGROUND: Frequent exacerbations are an important cause of morbidity in patients with severe asthma. OBJECTIVE: Our aim was to identify factors associated with frequent exacerbations in a large well-characterized severe ... -
Senescence under appraisal: hopes and challenges revisited.
(Springer Nature, 2021-01-13)In recent years, cellular senescence has become the focus of attention in multiple areas of biomedical research. Typically defined as an irreversible cell cycle arrest accompanied by increased cellular growth, metabolic ... -
Protective activities of distinct omega-3 enriched oils are linked to their ability to upregulate specialized pro-resolving mediators.
(Public Library of Science, 2020)Clinical studies using a range of omega-3 supplements have yielded conflicting results on their efficacy to control inflammation. Omega-3 fatty acids are substrate for the formation of potent immune-protective mediators, ... -
Utility of Immunology, Microbiology and Helminth Investigations in Clinical Assessment of Severe Asthma.
(2020-12-23)Objective: Systematic assessment of patients with potential severe asthma is key to identification of treatable traits and optimal management. Assessment of anti-microbial immune function is part of that assessment at many ... -
From Welfare to Warfare: The Arbitration of Host-Microbiota Interplay by the Type VI Secretion System.
(Frontiers Media, 2020)The health of mammals depends on a complex interplay with their microbial ecosystems. Compartments exposed to external environments such as the mucosal surfaces of the gastrointestinal tract accommodate the gut microbiota, ... -
An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo.
(2014-03)The phagocytosis of apoptotic cells (ACs), or efferocytosis, by DCs is critical for self-tolerance and host defense. Although many efferocytosis-associated receptors have been described in vitro, the functionality of these ... -
Identification of a non-growth factor role for GM-CSF in advanced atherosclerosis: promotion of macrophage apoptosis and plaque necrosis through IL-23 signaling.
(2015-01-16)RATIONALE: Granulocyte macrophage colony-stimulating factor (GM-CSF, Csf2) is a growth factor for myeloid-lineage cells that has been implicated in the pathogenesis of atherosclerosis and other chronic inflammatory diseases. ... -
CHARACTERISTICS OF PATIENTS IN THE UK SEVERE ASTHMA REGISTRY: VARIATION BY ETHNICITY
(2019-11-12)Abstract P152 from British Thoracic Society Winter Meeting 2019, QEII Centre, Broad Sanctuary, Westminster, London SW1P 3EE, 4 to 6 December 2019 -
Upregulation of ICAM-1 expression on J774.2 macrophages by endotoxin involves activation of NF-kappaB but not protein tyrosine kinase: comparison to induction of iNOS.
(1999)This study compares the signal transduction pathway which leads to the upregulation of intercellular adhesion molecule-1 (ICAM-1) expression with that of the increase in the expression of inducible nitric oxide synthase ...