Warwick Hip Trauma Study: a randomised clinical trial comparing interventions to improve outcomes in internally fixed intracapsular fractures of the proximal femur. Protocol for the WHiT Study.
View/ Open
Volume
11
Publisher
Publisher URL
DOI
10.1186/1471-2474-11-184
Journal
BMC Musculoskeletal Disorders
Metadata
Show full item recordAbstract
BACKGROUND: Controversy exists regarding the optimal treatment for patients with displaced intracapsular fractures of the proximal femur. The recognised treatment alternatives are arthroplasty and internal fixation. The principal criticism of internal fixation is the high rate of non-union; up to 30% of patients will have a failure of the fixation leading to revision surgery. We believe that improved fracture healing may lead to a decreased rate of failure of fixation. We therefore propose to investigate strategies to both accelerate fracture healing and improve fixation that may significantly improve outcomes after internal fixation of intracapsular femoral fractures. We aim to test the clinical effectiveness of the osteoinductive agent platelet rich plasma and conduct a pilot study of a novel fixed-angle fixation system. DESIGN: We have planned a three arm, single centre, standard-of-care controlled, double blinded, pragmatic, randomised clinical trial. The trial will include a standard two-way comparison between platelet-rich plasma and standard-of-care fixation versus standard-of-care fixation alone. In addition there will be a subsidiary pilot arm testing a fixed-angle screw and plate fixation system. TRIAL REGISTRATION: Current Controlled Trials ISRCTN49197425.
Authors
Griffin, XL; Parsons, N; Achten, J; Costa, MLCollections
Language
Licence information
Except where otherwise noted, this item's license is described as Open Access article distributed under the terms of the Creative Commons Attribution License
Related items
Showing items related by title, author, creator and subject.
-
Assessing fracture risk in people with MS: a service development study comparing three fracture risk scoring systems
Dobson, R; Leddy, SG; Gangadharan, S; Giovannoni, G (BMJ Publishing Group Ltd, 2013-03-11)Objectives Suboptimal bone health is increasingly recognised as an important cause of morbidity. Multiple sclerosis (MS) has been consistently associated with an increased risk of osteoporosis and fracture. Various fracture ... -
Ultrahigh Recovery of Fracture Strength on Mismatched Fractured Amorphous Surfaces of Silicon Carbide
Cui, J; Zhang, Z; Jiang, H; Liu, D; Zou, L; Guo, X; Lu, Y; Parkin, IP; Guo, D (2019-07) -
Intramedullary nails versus distal locking plates for fracture of the distal femur: results from the Trial of Acute Femoral Fracture Fixation (TrAFFix) randomised feasibility study and process evaluation.
Griffin, XL; Costa, ML; Phelps, E; Parsons, N; Dritsaki, M; Achten, J; Tutton, E; Lerner, RG; McGibbon, A; Baird, J (BMJ Publishing Group, 2019-05-05)Objectives This feasibility study and process evaluation assessed the likely success of a definitive trial of intramedullary fixation with locked retrograde nails versus extramedullary fixation with fixed angle plates for ...