Browsing Centre for Neuroscience, Surgery and Trauma by Issue Date
Now showing items 1-20 of 1367
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Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism
(Wiley, 1986)MDL 72222, the selective 5-hydroxytryptamine (5-HT) M-receptor antagonist, prevented or reduced cisplatin-induced emesis in ferrets. It is suggested that cisplatin-induced, and possibly other cytotoxic drug-induced vomiting ... -
Evidence that 5-hydroxytryptamine3 receptors mediate cytotoxic drug and radiation-evoked emesis
(Macmillan Press, 1987)The involvement of 5-hydroxytryptamine (5-HT) 5-HT3 receptors in the mechanisms of severe emesis evoked by cytotoxic drugs or by total body irradiation have been studied in ferrets. Anti-emetic compounds tested were ... -
The anti-emetic potential of the 5-hydroxytryptamine3 receptor antagonist BRL 43694.
(1988-11)In ferrets, the selective 5-hydroxytryptamine (5-HT) 5-HT3 receptor antagonist BRL 43694 given as a single injection (0.05-0.5 mg kg-1 i.v.) before cisplatin, or by divided dose (2 x 0.005-2 x 0.5 mg kg-1 i.v.) before and ... -
Pancreatic secretory trypsin inhibitor in gastrointestinal mucosa and gastric juice.
(1990-11)We studied the distribution of pancreatic secretory trypsin inhibitor (PSTI) in the epithelia of the gastrointestinal tract and determined whether PSTI is secreted into gastric juice. PSTI was measured by a specific ... -
Gastric output of pancreatic secretory trypsin inhibitor is increased by misoprostol.
(1991-11)Pancreatic secretory trypsin inhibitor (PSTI) is a potent protease inhibitor that also has growth promoting activity. It has recently been identified in the foveolar cells of the stomach, which secrete mucus. We examined ... -
The cleavage of the bait region of a2-macroglobulin by human immunodeficiency proteinases and by astacin.
(Annals of the New York Academy, 1994) -
Vector manometry and LOS dynamics.
(2000-05) -
Idiopathic slow transit constipation and megacolon are not associated with neurturin mutations.
(Wiley, 2002-10-02)Chronic idiopathic slow-transit constipation (ISTC) and idiopathic megacolon (IMC) are early-onset gastrointestinal motility disorders of unknown aetiology. The gene encoding the neurotrophic factor neurturin may be a ... -
Comparative analysis of the time-dependent functional and molecular changes in spinal cord degeneration induced by the G93A SOD1 gene mutation and by mechanical compression
(BioMed Central, 2008-10-23)Background Mutations of the superoxide dismutase 1 (SOD1) gene are linked to amyotrophic lateral sclerosis (ALS), an invariably fatal neurological condition involving cortico-spinal degeneration. Mechanical injury can ... -
B Cells and EBV Infection in People with MS
(2009-03-17) -
Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: New data and meta-analysis.
(Wiley, 2010-01)Conflicting results have been reported as to whether genetic variations (Val66Met and C270T) of the brain-derived neurotrophic factor gene (BDNF) confer susceptibility to Alzheimer's disease (AD). We genotyped these ...