Browsing Centre for Neuroscience, Surgery and Trauma by Issue Date
Now showing items 1-20 of 1145
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Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism
(Wiley, 1986)MDL 72222, the selective 5-hydroxytryptamine (5-HT) M-receptor antagonist, prevented or reduced cisplatin-induced emesis in ferrets. It is suggested that cisplatin-induced, and possibly other cytotoxic drug-induced vomiting ... -
Evidence that 5-hydroxytryptamine3 receptors mediate cytotoxic drug and radiation-evoked emesis
(Macmillan Press, 1987)The involvement of 5-hydroxytryptamine (5-HT) 5-HT3 receptors in the mechanisms of severe emesis evoked by cytotoxic drugs or by total body irradiation have been studied in ferrets. Anti-emetic compounds tested were ... -
The anti-emetic potential of the 5-hydroxytryptamine3 receptor antagonist BRL 43694.
(1988-11)In ferrets, the selective 5-hydroxytryptamine (5-HT) 5-HT3 receptor antagonist BRL 43694 given as a single injection (0.05-0.5 mg kg-1 i.v.) before cisplatin, or by divided dose (2 x 0.005-2 x 0.5 mg kg-1 i.v.) before and ... -
Pancreatic secretory trypsin inhibitor in gastrointestinal mucosa and gastric juice.
(1990-11)We studied the distribution of pancreatic secretory trypsin inhibitor (PSTI) in the epithelia of the gastrointestinal tract and determined whether PSTI is secreted into gastric juice. PSTI was measured by a specific ... -
Gastric output of pancreatic secretory trypsin inhibitor is increased by misoprostol.
(1991-11)Pancreatic secretory trypsin inhibitor (PSTI) is a potent protease inhibitor that also has growth promoting activity. It has recently been identified in the foveolar cells of the stomach, which secrete mucus. We examined ... -
The cleavage of the bait region of a2-macroglobulin by human immunodeficiency proteinases and by astacin.
(Annals of the New York Academy, 1994) -
Vector manometry and LOS dynamics.
(2000-05) -
Idiopathic slow transit constipation and megacolon are not associated with neurturin mutations.
(Wiley, 2002-10-02)Chronic idiopathic slow-transit constipation (ISTC) and idiopathic megacolon (IMC) are early-onset gastrointestinal motility disorders of unknown aetiology. The gene encoding the neurotrophic factor neurturin may be a ... -
Comparative analysis of the time-dependent functional and molecular changes in spinal cord degeneration induced by the G93A SOD1 gene mutation and by mechanical compression
(BioMed Central, 2008-10-23)Background Mutations of the superoxide dismutase 1 (SOD1) gene are linked to amyotrophic lateral sclerosis (ALS), an invariably fatal neurological condition involving cortico-spinal degeneration. Mechanical injury can ... -
B Cells and EBV Infection in People with MS
(2009-03-17) -
Managing anticoagulated patients during neuraxial anaesthesia.
(2010-04)The widespread use of central neuraxial block (CNB) and the prevalence of anticoagulation for different indications have led to an inevitable overlap between the two. The most serious complication of CNB in anticoagulated ...
