Browsing Centre for Neuroscience, Surgery and Trauma by Issue Date
Now showing items 1-20 of 1406
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Effectiveness of behavior change in rehabilitation interventions to improve functional recovery after lower limb fracture: a systematic review.
(Springer, 02-07-2024)Ankle fractures are common injuries that can significantly impact mobility and quality of life. Rehabilitation following ankle fracture treatment is crucial for recovery, yet adherence to regimens remains a challenge. ... -
Patient experiences and desires for recovery after ankle fracture surgery
(Elsevier, 02-08-2024)Objective This study investigates patients’ experiences of commencing weight-bearing after ankle fracture surgery and their recovery priorities to inform a new rehabilitation intervention. Methods Embedded within the ... -
Early versus delayed weight-bearing following operatively treated ankle fracture (WAX). A randomised controlled trial and health economic evaluation
(Elsevier, 04-06-2024)Background After surgery for a broken ankle, patients are usually instructed to avoid walking for 6 weeks (delayed weight-bearing). Walking 2 weeks after surgery (early weight-bearing) might be a safe and preferable ... -
Transobturator-cable-fixation in pelvic ring injuries with symphyseal disruption – A last resort?
(Springer, 07-08-2024)Purpose The role of transobturator-cable-fixation (TOCF) in traumatic symphyseal rupture of the pelvic ring remains unclear. This case series aims to evaluate TOCF in complex and revision cases in pelvic surgery. Methods A ... -
Delocalized quinolinium-macrocyclic peptides, an atypical chemotype for CNS penetration
(American Association for the Advancement of Science, 10-07-2024)Macrocyclic drugs can address an increasing range of molecular targets but enabling central nervous system (CNS) access to these drugs has been viewed as an intractable problem. We designed and synthesized a series of ... -
Protocol for a feasibility randomised controlled trial of the ‘Outdoor’ mobility intervention for older adults after hip fracture
(Public Library of Science, 12-08-2024)Background A high proportion of patients do not regain outdoor mobility after hip fracture. Rehabilitation explicitly targeting outdoor mobility is needed to enable these older adults to recover activities which they value ... -
Research priorities for the management of major trauma: an international priority setting partnership with the James Lind Alliance
(BMJ Publishing Group, 15-05-2024)Objective The objective of this study is to determine research priorities for the management of major trauma, representing the shared priorities of patients, their families, carers and healthcare professionals. Design/setting ... -
Research priorities for the management of major trauma: an international priority setting partnership with the James Lind Alliance
(BMJ Publishing Group, 15-05-2024)Objective The objective of this study is to determine research priorities for the management of major trauma, representing the shared priorities of patients, their families, carers and healthcare professionals. Design/setting ... -
Every minute counts: a comparison of thawing times and haemostatic quality of plasma thawed at 37 o C and 45 o C using four different methods
(Wiley, 23-06-2024)Background Having faster plasma thawing devices could be beneficial for transfusion services, as it may improve the rapid availability of thawed plasma for bleeding patients, and it might remove the need to have extended ... -
Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism
(Wiley, 1986)MDL 72222, the selective 5-hydroxytryptamine (5-HT) M-receptor antagonist, prevented or reduced cisplatin-induced emesis in ferrets. It is suggested that cisplatin-induced, and possibly other cytotoxic drug-induced vomiting ... -
Evidence that 5-hydroxytryptamine3 receptors mediate cytotoxic drug and radiation-evoked emesis
(Macmillan Press, 1987)The involvement of 5-hydroxytryptamine (5-HT) 5-HT3 receptors in the mechanisms of severe emesis evoked by cytotoxic drugs or by total body irradiation have been studied in ferrets. Anti-emetic compounds tested were ... -
The anti-emetic potential of the 5-hydroxytryptamine3 receptor antagonist BRL 43694.
(1988-11)In ferrets, the selective 5-hydroxytryptamine (5-HT) 5-HT3 receptor antagonist BRL 43694 given as a single injection (0.05-0.5 mg kg-1 i.v.) before cisplatin, or by divided dose (2 x 0.005-2 x 0.5 mg kg-1 i.v.) before and ... -
Pancreatic secretory trypsin inhibitor in gastrointestinal mucosa and gastric juice.
(1990-11)We studied the distribution of pancreatic secretory trypsin inhibitor (PSTI) in the epithelia of the gastrointestinal tract and determined whether PSTI is secreted into gastric juice. PSTI was measured by a specific ... -
Gastric output of pancreatic secretory trypsin inhibitor is increased by misoprostol.
(1991-11)Pancreatic secretory trypsin inhibitor (PSTI) is a potent protease inhibitor that also has growth promoting activity. It has recently been identified in the foveolar cells of the stomach, which secrete mucus. We examined ... -
The cleavage of the bait region of a2-macroglobulin by human immunodeficiency proteinases and by astacin.
(Annals of the New York Academy, 1994) -
Vector manometry and LOS dynamics.
(2000-05) -
Idiopathic slow transit constipation and megacolon are not associated with neurturin mutations.
(Wiley, 2002-10-02)Chronic idiopathic slow-transit constipation (ISTC) and idiopathic megacolon (IMC) are early-onset gastrointestinal motility disorders of unknown aetiology. The gene encoding the neurotrophic factor neurturin may be a ...
