Browsing Centre for Neuroscience, Surgery and Trauma by Title
Now showing items 1-20 of 450
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The 1980s: D-AP5, LTP and a Decade of NMDA Receptor Discoveries.
(2018-10-04)In the 1960s and 70s, biochemical and pharmacological evidence was pointing toward glutamate as a synaptic transmitter at a number of distinct receptor classes, known as NMDA and non-NMDA receptors. The field, however, ... -
3D high-resolution anorectal manometry in patients with perianal fistulas: comparison with 3D-anal ultrasound.
(2018-04-04)BACKGROUND: Perianal fistula surgery can damage the anal sphincters which may cause faecal incontinence. By measuring regional pressures, 3D-HRAM potentially provides better guidance for surgical strategy in patients with ... -
Age, gender and stage matched controlled comparative study of signet vs. non-signet ring call lower GI cancers
(John Wiley & Sons, 2014-09-23) -
Alemtuzumab CARE-MS II 5-year follow-up: Efficacy and safety findings.
(2017-09-12)OBJECTIVE: To evaluate 5-year efficacy and safety of alemtuzumab in patients with active relapsing-remitting multiple sclerosis and inadequate response to prior therapy. METHODS: In the 2-year Comparison of Alemtuzumab and ... -
Alemtuzumab depletion failure can occur in multiple sclerosis.
(2018-06)Alemtuzumab is a lymphocyte-depleting antibody and one of the most effective treatments for relapsing multiple sclerosis. However, it also causes loss of immune-tolerance leading to secondary autoimmunity and marked anti-drug ... -
Altered defaecatory behaviour and faecal incontinence in a video-tracked animal model of pudendal neuropathy
(Wiley on behalf of Association of Coloproctology of Great Britain and Ireland, 2017-03-20)Aim: The aim was to develop a behavioural animal model of faecal continence and assess the effect of retro‐uterine balloon inflation (RBI) injury. RBI in the rat causes pudendal neuropathy, a risk factor for obstetric ... -
Ambulatory assessment of colonic motility using the electromagnetic capsule tracking system.
(2019-02)BACKGROUND: The Motilis 3D-Transit system tracks electromagnetic capsules as they traverse the gastrointestinal tract. The method is minimally invasive and ambulatory. Analysis has previously been limited to regional gut ...
