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"This is the peer reviewed version of the following article: Romão, V.C., Polido‐Pereira, J., Barros, R., Luís, R., Vidal, B., Vieira‐Sousa, E., Vitorino, E., Humby, F., Kelly, S., Pitzalis, C., Saraiva, F. and Fonseca, J.E. (2020), Efficacy, safety and sample quality of ultrasound‐guided synovial needle biopsy in clinical practice and research: a prospective observational study. Arthritis Care Res. Accepted Author Manuscript. doi:10.1002/acr.24050 which has been published in final form at https://doi.org/10.1002/acr.24050. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."