Browsing Experimental Medicine & Rheumatology by Title

ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity

Massara, M; Bonavita, O; Savino, B; Caronni, N; Poeta, VM; Sironi, M; Setten, E; Recordati, C; Crisafulli, L; Ficara, F (2018-02-14)

Association of Defective Regulation of Autoreactive Interleukin-6-Producing Transitional B Lymphocytes With Disease in Patients With Systemic Sclerosis.

Taher, TE; Ong, VH; Bystrom, J; Hillion, S; Simon, Q; Denton, CP; Pers, J-O; Abraham, DJ; Mageed, RA (2018-03)

OBJECTIVE: Systemic sclerosis (SSc) has the highest case-specific mortality of any rheumatic disease, and no effective therapy is available. A clear manifestation of SSc is the presence of autoantibodies. However, the ...

Autoantibodies targeting TLR and SMAD pathways define new subgroups in systemic lupus erythematosus

Lewis, MJ; McAndrew, MB; Wheeler, C; Workman, N; Agashe, P; Koopmann, J; Uddin, E; Morris, DL; Zou, L; Stark, R (2018-07)

Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1 beta in chondrocyte/agarose constructs

Ramachandran, M; Achan, P; Salter, DM; Bader, DL; Chowdhury, TT (2011)

A comparative study of matrix metalloproteinase and aggrecanase mediated release of latent cytokines at arthritic joints

Mullen, L; Adams, G; Foster, J; Vessillier, S; Koester, M; Hauser, H; Layward, L; Gould, D; Chernajovsky, Y (2014-09)

Endothelial Dysfunction in Systemic Lupus Erythematosus: Pathogenesis, Assessment and Therapeutic Opportunities.

Mauro, D; Nerviani, A (2018)

BACKGROUND: Systemic Lupus Erythematosus (SLE) is characterised by increased mortality secondary to Cardiovascular Diseases (CVD). Despite being common in SLE, traditional cardiovascular risk factors cannot entirely justify ...

Functional and phenotypic heterogeneity of Th17 cells in health and disease.

Bystrom, J; Clanchy, FIL; Taher, TE; Al-Bogami, M; Ong, VH; Abraham, DJ; Williams, RO; Mageed, RA (2019-01)

BACKGROUND: Th17 cells have nonredundant roles in maintaining immunity, particularly at mucosal surfaces. These roles are achieved principally through the production of cytokines and the recruitment of other immune cells ...

Guidelines and Pathways for Clinical Practice in Tendinopathy: Their Role and Development

Morrissey, D (2015-11)

In-depth characterization of CD24(high)CD38(high) transitional human B cells reveals different regulatory profiles

Simon, Q; Pers, J-O; Cornec, D; Le Pottier, L; Mageed, RA; Hillion, S (2016-05)

The interaction of hip and foot biomechanics in the presentation and management of patellofemoral pain.

Lack, S (2018-04)

Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity

Taher, ET; Bystrom, J; Ong, VH; Isenberg, DA; Renaudineau, Y; Abraham, DJ; Mageed, RA (2017-10)

The long pentraxin PTX3: A prototypical sensor of tissue injury and a regulator of homeostasis

Erreni, M; Manfredi, AA; Garlanda, C; Mantovani, A; Rovere-Querini, P (2017-11)

Mandatory vaccination in Italy: Time for engagement of immunologists

Mantovani, A; Santoni, A (2018-01)

Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production

Rivellese, F; Mauro, D; Nerviani, A; Pagani, S; Fossati-Jimack, L; Messemaker, T; Kurreeman, FAS; Toes, REM; Ramming, A; Rauber, S (2018-12)

Mast cells in rheumatoid arthritis: friends or foes?

Rivellese, F; Nerviani, A; Rossi, FW; Marone, G; Matucci-Cerinic, M; de Paulis, A; Pitzalis, C (2017-06)

A Multicenter Retrospective Analysis Evaluating Performance of Synovial Biopsy Techniques in Patients With Inflammatory Arthritis Arthroscopic Versus Ultrasound-Guided Versus Blind Needle Biopsy

Humby, F; Romao, VC; Manzo, A; Filer, A; Bugatti, S; Vieira-Sousa, E; Kelly, S; Wechalekar, M; Ahmed, M; Rocher, V (2018-05)

Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages.

Rhys, HI; Dell'Accio, F; Pitzalis, C; Moore, A; Norling, LV; Perretti, M (2018-03)

Microvesicles (MVs) are emerging as a novel means to enact cell-to-cell communication in inflammation. Here, we aimed to ascertain the ability of neutrophil-derived MVs to modulate target cell behaviour, the focus being ...