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"This is the peer reviewed version of the following article: Baker, D., Pryce, G., James, L.K., Schmierer, K. and Giovannoni, G. (2020), Failed B cell survival factor trials support the importance of memory B cells in multiple sclerosis. Eur J Neurol, 27: 221-228. doi:10.1111/ene.14105 which has been published in final form athttps://doi.org/10.1111/ene.14105. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."