Allostasis and the origins of adult-onset diabetes.
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Volume
63
Pagination
261 - 265
DOI
10.1007/s00125-019-05048-9
Journal
Diabetologia
Issue
Metadata
Show full item recordAbstract
Physiological plasticity enables homeostasis to be maintained in biological systems, but when such allostasis fails, then disease can develop. In a new population-based study by Rolandsson et al (https://doi.org/10.1007/s00125-019-05016-3), autoimmunity, defined by an immunogenotype, predicted adult-onset non-insulin requiring diabetes. Type 1 diabetes is no longer viewed as a disease confined to children, with a significant proportion, maybe the majority, presenting in adulthood. Such cases masquerade as type 2 diabetes and their identification has clinical utility. Nevertheless, in this study, autoimmunity had a limited effect on the overall risk of adults developing diabetes.
Authors
Leslie, RD; Vartak, TCollections
- Centre for Immunobiology [1121]