dc.contributor.author | Leslie, RD | en_US |
dc.contributor.author | Vartak, T | en_US |
dc.date.accessioned | 2020-01-24T11:38:07Z | |
dc.date.issued | 2020-02 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/62519 | |
dc.description.abstract | Physiological plasticity enables homeostasis to be maintained in biological systems, but when such allostasis fails, then disease can develop. In a new population-based study by Rolandsson et al (https://doi.org/10.1007/s00125-019-05016-3), autoimmunity, defined by an immunogenotype, predicted adult-onset non-insulin requiring diabetes. Type 1 diabetes is no longer viewed as a disease confined to children, with a significant proportion, maybe the majority, presenting in adulthood. Such cases masquerade as type 2 diabetes and their identification has clinical utility. Nevertheless, in this study, autoimmunity had a limited effect on the overall risk of adults developing diabetes. | en_US |
dc.format.extent | 261 - 265 | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Diabetologia | en_US |
dc.rights | Creative Commons Attribution 4.0 International License | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Autoantibodies | en_US |
dc.subject | Autoimmunity | en_US |
dc.subject | C-peptide | en_US |
dc.subject | Diabetes | en_US |
dc.subject | Diabetes heterogeneity | en_US |
dc.subject | Diabetes risk | en_US |
dc.subject | Genetics | en_US |
dc.title | Allostasis and the origins of adult-onset diabetes. | en_US |
dc.type | Article | |
dc.rights.holder | © The Author(s) 2019 | |
dc.identifier.doi | 10.1007/s00125-019-05048-9 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/31813006 | en_US |
pubs.issue | 2 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 63 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |