Browsing Biology by Title
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10 years into the resurgence of covalent drugs.
(2021-01)In the first decade of targeted covalent inhibition, scientists have successfully reversed the previous trend that had impeded the use of covalent inhibition in drug development. Successes in the clinic, mainly in the field ... -
A 160 Gbp fork fern genome shatters size record for eukaryotes
(Cell Press (Elsevier), 2024-05-31)Vascular plants are exceptional among eukaryotes due to their outstanding genome size diversity which ranges ∼2,400-fold, including the largest genome so far recorded in the angiosperm Paris japonica (148.89 Gbp/1C). Despite ... -
Airborne eDNA documents a diverse and ecologically complex tropical bat and other mammal community
(2023-03-01)Environmental (e)DNA has rapidly become a powerful biomonitoring tool, particularly in aquatic ecosystems. This approach has not been as widely adopted in terrestrial communities where the methods of vertebrate eDNA ... -
Altered lipid acyl chain length controls energy dissipation in light-harvesting complex II proteoliposomes by hydrophobic mismatch.
(2023-09)In plants, the major light-harvesting antenna complex (LHCII) is vital for both light harvesting and photoprotection in photosystem II. Previously, we proposed that the thylakoid membrane itself could switch LHCII into the ... -
Approaches to Learning to Control Dynamic Uncertainty
(MDPI AG, 2015-10-10)In dynamic environments, when faced with a choice of which learning strategy to adopt, do people choose to mostly explore (maximizing their long term gains) or exploit (maximizing their short term gains)? More to the point, ... -
The Aquatic Symbiosis Genomics Project: probing the evolution of symbiosis across the Tree of Life
(F1000Research, 2024-06-10)We present the Aquatic Symbiosis Genomics Project, a global collaboration to generate high quality genome sequences for a wide range of eukaryotes and their microbial symbionts. Launched under the Symbiosis in Aquatic ... -
Assessing the degradation of environmental DNA and RNA based on genomic origin in a metabarcoding context
(2023-01-01)Molecular tools of species identification based on eNAs (environmental nucleic acids; environmental DNA [eDNA] and environmental RNA [eRNA]) have the potential to greatly transform biodiversity science. However, the ability ... -
Beyond targeted protein degradation: LD·ATTECs clear cellular lipid droplets
(Springer Science and Business Media LLC, 2021-09) -
Blocking Kallikrein 6 promotes developmental myelination
(Wiley, 2022-03)<jats:title>Abstract</jats:title><jats:p>Kallikrein related peptidase 6 (Klk6) is a secreted serine protease highly expressed in oligodendrocytes and implicated in demyelinating conditions. To gain insights into the ...