Browsing Biology by Title
Now showing items 50-69 of 93
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Identification of the first structurally validated covalent ligands of the small GTPase RAB27A
(Royal Society of Chemistry (RSC), 2022-02-23) -
A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion.
(2022-12-14)Pancreatic cancer has the lowest survival rate of all common cancers due to late diagnosis and limited treatment options. Serine hydrolases are known to mediate cancer progression and metastasis through initiation of ... -
Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)
(Royal Society of Chemistry (RSC), 2022-09-29) -
The Missing Link between (Un)druggable and Degradable KRAS
(American Chemical Society (ACS), 2020-08-26) -
mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity.
(2022-09-29)Necrosis of macrophages in the granuloma, the hallmark immunological structure of tuberculosis, is a major pathogenic event that increases host susceptibility. Through a zebrafish forward genetic screen, we identified the ... -
Native diversity buffers against severity of non-native tree invasions.
(2023-08-23)Determining the drivers of non-native plant invasions is critical for managing native ecosystems and limiting the spread of invasive species1,2. Tree invasions in particular have been relatively overlooked, even though ...