Browsing Biology by Issue Date
Now showing items 1-20 of 40
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Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.
(2012-11)Nitroheterocyclic prodrugs are used to treat infections caused by Trypanosoma cruzi and Trypanosoma brucei. A key component in selectivity involves a specific activation step mediated by a protein homologous with type I ... -
Using geographic profiling to locate elusive nocturnal animals: A case study with spectral tarsiers
(2015-01-01)© 2015 The Zoological Society of London. Estimates of biodiversity, population size, population density and habitat use have important implications for management of both species and habitats, yet are based on census data ... -
Approaches to Learning to Control Dynamic Uncertainty
(MDPI AG, 2015-10-10)In dynamic environments, when faced with a choice of which learning strategy to adopt, do people choose to mostly explore (maximizing their long term gains) or exploit (maximizing their short term gains)? More to the point, ... -
Solid-state NMR structure of a pathogenic fibril of full-length human alpha-synuclein
(Nature Publishing Group, 2016-03-28)Misfolded a-synuclein amyloid fibrils are the principal components of Lewy bodies and neurites, hallmarks of Parkinson’s disease (PD). We present a high-resolution structure of an a-synuclein fibril, in a form that induces ...
