Biology
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Robustness of the microtubule network self-organization in epithelia.
(2021-02-01)Robustness of biological systems is crucial for their survival, however, for many systems its origin is an open question. Here, we analyze one subcellular level system, the microtubule cytoskeleton. Microtubules self-organize ... -
Interactions and Feedbacks in E-Cadherin Transcriptional Regulation.
(2021)Epithelial tissues rely on the adhesion between participating cells to retain their integrity. The transmembrane protein E-cadherin is the major protein that mediates homophilic adhesion between neighbouring cells and is, ... -
The Cross-Talk Between EGFR and E-Cadherin.
(2021)Epidermal growth factor receptor (EGFR) and adhesion protein E-cadherin are major regulators of proliferation and differentiation in epithelial cells. Consistently, defects in both EGFR and E-cadherin-mediated intercellular ... -
Transcriptional and post-transcriptional regulation of checkpoint genes on the tumour side of the immunological synapse.
(2022-07)Cancer is a disease of the genome, therefore, its development has a clear Mendelian component, demonstrated by well-studied genes such as BRCA1 and BRCA2 in breast cancer risk. However, it is known that a single genetic ... -
Multifaceted control of E-cadherin dynamics by Adaptor Protein Complex 1 during epithelial morphogenesis.
(2022-08-01)Intracellular trafficking regulates the distribution of transmembrane proteins including the key determinants of epithelial polarity and adhesion. The Adaptor Protein 1 (AP-1) complex is the key regulator of vesicle sorting, ... -
Deciphering the roles of cell shape and Fat and Dachsous planar polarity in arranging the Drosophila apical microtubule network through quantitative image analysis.
(2023-05-15)In epithelial cells, planar polarization of subapical microtubule networks is thought to be important for both breaking cellular symmetry and maintaining the resulting cellular polarity. Studies in the Drosophila pupal ... -
STORM imaging reveals the spatial arrangement of transition zone components and IFT particles at the ciliary base in Tetrahymena.
(2021-04-12)The base of the cilium comprising the transition zone (TZ) and transition fibers (TF) acts as a selecting gate to regulate the intraflagellar transport (IFT)-dependent trafficking of proteins to and from cilia. Before ... -
Evolutionary shifts in the thermal biology of a subterranean mammal: the effect of habitat aridity.
(2024-10-18)Subterranean mammals representing a single subspecies occurring along an aridity gradient provide an appropriate model for investigating adaptive variation in thermal physiology with varying levels of precipitation and air ... -
What is chemical biology?
(Elsevier BV, 2024-09) -
The global distribution and drivers of wood density and their impact on forest carbon stocks.
(Springer Nature, 2024-10-15)The density of wood is a key indicator of the carbon investment strategies of trees, impacting productivity and carbon storage. Despite its importance, the global variation in wood density and its environmental controls ... -
Molecular and cellular insight into Escherichia coli SslE and its role during biofilm maturation
(Microbiology Society, 2022-05-18) -
Molecular Evolution of Far-Red Light-Acclimated Photosystem II
(MDPI, 2022-06-22)Cyanobacteria are major contributors to global carbon fixation and primarily use visible light (400−700 nm) to drive oxygenic photosynthesis. When shifted into environments where visible light is attenuated, a small, but ... -
The Evolution and Evolvability of Photosystem II
(Annual Reviews, 2023-03-08)Photosystem II is the water-oxidizing and O2-evolving enzyme of photosynthesis. How and when this remarkable enzyme arose are fundamental questions in the history of life that have remained difficult to answer. Here, recent ... -
Molecular diversity and evolution of far-red light-acclimated photosystem I
(Frontiers, 2023-11-20)The need to acclimate to different environmental conditions is central to the evolution of cyanobacteria. Far-red light (FRL) photoacclimation, or FaRLiP, is an acclimation mechanism that enables certain cyanobacteria to ... -
Simultaneous Inference of Past Demography and Selection from the Ancestral Recombination Graph under the Beta Coalescent
(2024-01-01)The reproductive mechanism of a species is a key driver of genome evolution. The standard Wright-Fisher model for the reproduction of individuals in a population assumes that each individual produces a number of offspring ... -
Author Correction: STORM imaging reveals the spatial arrangement of transition zone components and IFT particles at the ciliary base in Tetrahymena (Scientific Reports, (2021), 11, 1, (7899), 10.1038/s41598-021-86909-5)
(Nature Research, 2022-03-07)The original version of this Article contained an error in Affiliation 2, which was incorrectly given as ‘Laboratory of Cytoskeleton and Cilia Biology, 3 Pasteur Street, 02-093, Warsaw, Poland’. The correct affiliation is ... -
The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth.
(2017)Cell size is amenable by genetic and environmental factors. The highly conserved nutrient-responsive Target of Rapamycin (TOR) signaling pathway regulates cellular metabolic status and growth in response to numerous inputs. ... -
Excitation dynamics and relaxation in the major antenna of a marine green alga Bryopsis corticulans.
(2020-06-01)The light-harvesting complexes II (LHCIIs) of spinach and Bryopsis corticulans as a green alga are similar in structure, but differ in carotenoid (Car) and chlorophyll (Chl) compositions. Carbonyl Cars siphonein (Spn) and ... -
Unravelling large-scale patterns and drivers of biodiversity in dry rivers.
(Springer Nature, 2024-08-22)More than half of the world's rivers dry up periodically, but our understanding of the biological communities in dry riverbeds remains limited. Specifically, the roles of dispersal, environmental filtering and biotic ...