Centre for Immunobiology: Recent submissions
Now showing items 641-660 of 1121
-
Chronic hepatitis B virus monoinfection at a university hospital in Zambia.
(2018-09-27)AIM: To characterize antiviral therapy eligibility among hepatitis B virus (HBV)-infected adults at a university hospital in Zambia. METHODS: Hepatitis B surface antigen-positive adults (n = 160) who were HIV-negative and ... -
The African Esophageal Cancer Consortium: A Call to Action.
(2018-09)Esophageal cancer is the eighth most common cancer worldwide and the sixth most common cause of cancer-related death; however, worldwide incidence and mortality rates do not reflect the geographic variations in the occurrence ... -
Emergence and nosocomial spread of carbapenem-resistant OXA-232-producing Klebsiella pneumoniae in Brunei Darussalam
(Elsevier Ltd., 2017-06-01)Objectives Carbapenem-resistant Enterobacteriaceae (CRE) are identified as a major global health concern. The success of CRE is facilitated by the emergence, acquisition and spread of successful clones carrying plasmid-encoded ... -
The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin
(Elsevier (Cell Press), 2017-09-05)Chromatin modifications and the promoter-associated epigenome are important for the regulation of gene expression. However, the mechanisms by which chromatin-modifying complexes are targeted to the appropriate gene promoters ... -
Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved
(Oxford University Press, 2016-08-19)DNA methylation is a repressive epigenetic modification that covers vertebrate genomes. Regions known as CpG islands (CGIs), which are refractory to DNA methylation, are often associated with gene promoters and play central ... -
Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming
(Elsevier, 2018-08-21)Epiblast cells in the early post-implantation stage mammalian embryo undergo a transition described as lineage priming before cell fate allocation, but signaling pathways acting upstream remain ill defined. Genetic studies ... -
Performing and interpreting individual pharmacokinetic profiles in patients with Hemophilia A or B: Rationale and general considerations.
(Taylor & Francis, 2018-05-20)In a separate document, we have provided specific guidance on performing individual pharmacokinetic (PK) studies using limited samples in persons with hemophilia with the goal to optimize prophylaxis with clotting factor ... -
Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A(3), a Neutrophil-activating Eicosanoid
(American Society for Biochemistry and Molecular Biology, 2016-06-24)Eicosanoids are important mediators of fever, pain, and inflammation that modulate cell signaling during acute and chronic disease. We show by using lipidomics that thrombinactivated human platelets generate a new type ... -
Mobilizing monocytes to cross-present circulating viral antigen in chronic infection
(American Society for Clinical Investigation, 2013-08-01)Selection of antigens for therapeutic vaccination against chronic viral infections is complicated by pathogen genetic variations. We tested whether antigens present during persistent viral infections could provide a ... -
A genotype-specific baseline score predicts post-treatment response to peginterferon alfa-2a in hepatitis B e antigen-negative chronic hepatitis B.
(Hellenic Society of Gastroenterology, 2018-07-26)Background: Peginterferon alfa-2a induces durable responses in some hepatitis B e antigen-negative patients, but robust pretreatment predictors are not available to identify likely responders. In this study we aimed to ... -
Circulating and intrahepatic antiviral B cells are defective in hepatitis B.
(American Society for Clinical Investigation, 2018-08-09)B cells are increasingly recognized as playing an important role in the ongoing control of hepatitis B virus (HBV). The development of antibodies against the viral surface antigen (HBV surface antigen [HBsAgs]) constitutes ... -
Fine needle aspirates comprehensively sample intrahepatic immunity.
(2018-11-28)OBJECTIVE: In order to refine new therapeutic strategies in the pipeline for HBV cure, evaluation of virological and immunological changes compartmentalised at the site of infection will be required. We therefore investigated ... -
Molecular Recalibration of PD-1+ Antigen-Specific T Cells from Blood and Liver.
(2018-11-07)Checkpoint inhibitors and adoptive cell therapy provide promising options for treating solid cancers such as HBV-related HCC, but they have limitations. We tested the potential to combine advantages of each approach, ... -
PD-1 blockade partially recovers dysfunctional virus-specific B cells in chronic hepatitis B infection.
(2018-10-01)Chronic HBV (CHB) infection suppresses virus-specific T cells, but its impact on humoral immunity has been poorly analyzed. Here, we developed a dual-staining method that utilizes hepatitis B virus (HBV) surface antigens ... -
A baseline tool for predicting response to peginterferon alfa-2a in HBeAg-positive patients with chronic hepatitis B
(Wiley, 2018-06-29)Background Peginterferon induces off‐treatment responses in approximately one‐third of patients with hepatitis B e antigen (HBeAg)‐positive chronic hepatitis B. Aim: To develop an easy‐to‐use baseline prediction score ... -
RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes
(eLife Sciences Publications, 2016-10-05)Polycomb group (PcG) proteins function as chromatin-based transcriptional repressors that are essential for normal gene regulation during development. However, how these systems function to achieve transcriptional ... -
Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation
(Elsevier, 2014-05-22)Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2 play an essential role in gene regulation, cellular differentiation, and development. However, the mechanisms by which these complexes ...