Centre for Immunobiology: Recent submissions
Now showing items 661-680 of 1121
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Hypoxic enhancement of exosome release by breast cancer cells
(BioMed Central, 2012-09-24)Background Exosomes are nanovesicles secreted by tumour cells which have roles in paracrine signalling during tumour progression, including tumour-stromal interactions, activation of proliferative pathways and bestowing ... -
IFITM proteins inhibit HIV-1 protein synthesis
(Nature Publishing Group, 2018-09-28)Interferon induced transmembrane proteins (IFITMs) inhibit the cellular entry of a broad range of viruses, but it has been suspected that for HIV-1 IFITMs may also inhibit a post-integration replicative step. We show that ... -
The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatroy element funciton in mouse embryonic stem cells
(eLife Sciences Publications, 2017-03-13)Pioneer transcription factors recognise and bind their target sequences in inaccessible chromatin to establish new transcriptional networks throughout development and cellular reprogramming. During this process, pioneer ... -
Development of novel anti-CD160 CARs
(2016-11)Conference: Conference on Changing the Face of Modern Medicine - Stem Cells and Gene Therapy Location: Florence, ITALY Date: OCT 18-21, 2016 -
Faster for less: the new "shorter" regimen for multidrug-resistant tuberculosis
(European Respiratory Society, 2016-10-31) -
Factor VIII cross-matches to the human proteome reduce the predicted inhibitor risk in missense mutation hemophilia A.
(Ferrata Storti Foundation, 2018-09-28)Single missense mutations in the F8 gene encoding the coagulation protein factor VIII (FVIII) give rise predominantly to non-severe hemophilia A. Despite only a single amino acid sequence difference between the replacement, ... -
The role of the multidisciplinary team in antifungal stewardship
(Oxford University Press, 2016-11-07)There are a variety of challenges faced in the management of invasive fungal diseases (IFD), including high casefatality rates, high cost of antifungal drugs and development of antifungal resistance. The diagnostic ... -
Why, who and when to start treatment for chronic hepatitis B infection.
(Elsevier, 2018-04-11)Chronic hepatitis B remains a major global health challenge due to morbidity and mortality from hepatocellular carcinoma and complications of liver cirrhosis. Current treatment regimens are non-curative and, once initiated, ... -
Characterization of a colistin-resistant Avian Pathogenic Escherichia coli ST69 isolate recovered from a broiler chicken in Germany.
(2019-01)In recent years, several plasmids harbouring genes encoding phosphoethanolamine transferases conferring colistin resistance have been described in multiple Enterobacteriaceae species. Avian Pathogenic E. coli (APEC) causes ... -
The Pathogenesis of Extraintestinal Manifestations: Implications for IBD Research, Diagnosis, and Therapy.
(2019-04-26)This article reports on the sixth scientific workshop of the European Crohn's and Colitis Organisation [ECCO] on the pathogenesis of extraintestinal manifestations [EIMs] in inflammatory bowel disease [IBD]. This paper has ... -
Intestinal Dendritic Cells in Health and Gut Inflammation
(2018-12-06) -
The impact of currently licensed therapies on viral and immune responses in Chronic Hepatitis B: considerations for future novel therapeutics.
(Blackwell publishing, 2018-11-11)Despite the availability of a preventative vaccine, chronic hepatitis B (CHB) remains a global healthcare challenge with the risk of disease progression due to cirrhosis and hepatocellular carcinoma. Although current ... -
Immune Reconstitution After Autologous Hematopoietic Stem Cell Transplantation in Crohn's Disease: Current Status and Future Directions. A Review on Behalf of the EBMT Autoimmune Diseases Working Party and the Autologous Stem Cell Transplantation In Refractory CD-Low Intensity Therapy Evaluation Study Investigators.
(2018)Patients with treatment refractory Crohn's disease (CD) suffer debilitating symptoms, poor quality of life, and reduced work productivity. Surgery to resect inflamed and fibrotic intestine may mandate creation of a stoma ...